Predictors of One-Year Mortality After Curative Surgery in Patients Aged 80 Years or Older With Non-Metastatic Colorectal Cancer

NCT06704646 | Completed

• 1 other identifier: 202003045RINB
• Study Type: observational
• Target: 310
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study is to determine which preoperative factors are associated with one-year postoperative mortality in patients aged ≥80 years undergoing curative surgery and compare outcomes between patients with or without risk factors.

Conditions

Colorectal Cancer

Keywords

Colorectal cancer; Geriatrics

Outcome Measures

Primary Outcomes (1)

• Preoperative factors associated with one-year postoperative mortality

  Univariate and multivariable logistic regression analysis were performed to identify preoperative factors associated with one-year postoperative mortality.

  From operation to one year after the surgery

Study Arms (2)

Patients passed away within one year

Records their age, gender, preoperative comorbidities, and calculated their Charlson comorbidity index. We also collected information on tumor location, serum levels of carcinoembryonic antigen (CEA), preoperative clinical TNM staging, and postoperative pathological TNM staging

Procedure: Curative intent surgery

Patient survived the first post-operative year

Records their age, gender, preoperative comorbidities, and calculated their Charlson comorbidity index. We also collected information on tumor location, serum levels of carcinoembryonic antigen (CEA), preoperative clinical TNM staging, and postoperative pathological TNM staging

Procedure: Curative intent surgery

Interventions

Curative intent surgery PROCEDURE

Curative intent surgery means that surgeons intend to perform R0 resection.

Patient survived the first post-operative year; Patients passed away within one year

Eligibility Criteria

• Age: 80 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This retrospective study was performed at National Taiwan University hospital. Patients aged ≥80 years with stages I-III colorectal cancer who underwent tumor resection from January 2014 to January 2019, and they were followed up until December 31, 2020. Patients undergoing procedure without colectomy, or tumor excised by transanal method were excluded from this study.

You may qualify if:

• Patients aged ≥80 years with stages I-III colorectal cancer who underwent tumor resection from January 2014 to January 2019

You may not qualify if:

• Patients undergoing procedure without colectomy, or tumor excised by transanal method were excluded from this study

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Related Publications (3)

• Keum N, Giovannucci E. Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. Nat Rev Gastroenterol Hepatol. 2019 Dec;16(12):713-732. doi: 10.1038/s41575-019-0189-8. Epub 2019 Aug 27.

  PMID: 31455888 BACKGROUND

• Chen B, Yu W, Ma Y, Xu P, Yao Q, Sun Q, Ren J, Wang D. Evaluation of the safety and efficacy of perform enterectomy in colorectal cancer patients aged 80 or older. A meta-analysis and a systematic review. Int J Colorectal Dis. 2023 Jul 3;38(1):185. doi: 10.1007/s00384-023-04461-2.

  PMID: 37395836 BACKGROUND

• Dekker JW, van den Broek CB, Bastiaannet E, van de Geest LG, Tollenaar RA, Liefers GJ. Importance of the first postoperative year in the prognosis of elderly colorectal cancer patients. Ann Surg Oncol. 2011 Jun;18(6):1533-9. doi: 10.1245/s10434-011-1671-x. Epub 2011 Mar 29.

  PMID: 21445672 BACKGROUND

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 21, 2024
• First Posted: November 26, 2024
• Study Start: January 1, 2014
• Primary Completion: December 31, 2020
• Study Completion: December 31, 2020
• Last Updated: November 27, 2024

Record last verified: 2020-12

Data Sharing

• IPD Sharing: Will not share