Optimization of Nutritional State on the Outcome of Patients with Acute Exacerbation of Bronchiectasis

NCT06704607 | Not Yet Recruiting

• 1 other identifier: Bronchiectas nutritional state
• Study Type: observational
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

Bronchiectasis is a chronic respiratory condition characterized by the abnormal and permanent dilation of the bronchi, leading to recurrent respiratory infections, chronic cough, and significant morbidity. The disease has gained increasing recognition due to its rising prevalence and the substantial burden it places on healthcare systems . Recent studies have highlighted the importance of nutritional status in managing chronic respiratory diseases, including bronchiectasis. Malnutrition is prevalent among patients with bronchiectasis, particularly those experiencing frequent exacerbations. It has been shown that underweight patients have lower lung function and may face worse clinical outcomes compared to those with normal weight . Specifically, a study found that underweight individuals had a significantly lower forced expiratory volume in one second (FEV1) compared to their normal-weight counterparts, indicating a direct correlation between nutritional status and respiratory function .

Conditions

Bronchiectasis Adult

Outcome Measures

Primary Outcomes (1)

• Asses The Change In Quality of life

  measured by the St. George's Respiratory Questionnaire (SGRQ).

  base line

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Recruitment Patients will be recruited from inpatient wards. Informed consent will be obtained from all participants prior to enrollment. Nutritional Assessment * \*\*Baseline Assessment\*\*: * Nutritional status will be determined using the Subjective Global Assessment (SGA) and biochemical markers (e.g., serum albumin). * Dietary intake will be assessed using a 3-day food diary or 24-hour dietary recall method. * \*\*Nutritional Optimization\*\*: Patients identified as malnourished will receive a tailored nutritional intervention, which may include: * High-protein dietary recommendations. * Caloric supplementation through protein shakes or high-calorie snacks. * Micronutrient supplementation as need Data Collection Data will be collected at three time points: 1. \*\*Baseline\*\*: Upon admission. 2. \*\*During Hospitalization\*\*: After the implementation of nutritional interventions. 3. \*\*Follow-Up\*\*: Six months post-discharge, assessing long-term outcomes.

You may qualify if:

• \*Age\*: Adults aged 18 years and older.
• Diagnosis\*: Confirmed diagnosis of bronchiectasis, as established by clinical evaluation and imaging studies (e.g., chest CT scan).
• Acute Exacerbation\*: Patients presenting with acute exacerbation symptoms, such as increased sputum production, worsening dyspnea, or chest pain.
• Nutritional Assessment\*: Patients identified as malnourished or at risk of malnutrition based on the Subjective Global Assessment (SGA) or similar nutritional screening tools.

You may not qualify if:

• \*Cognitive Impairment\*: Patients with cognitive impairments that affect their ability to participate in the study or adhere to nutritional recommendations.
• Current Enteral Feeding\*: Patients receiving enteral nutrition or those with a feeding tube.
• Recent Nutritional Interventions\*: Patients who have recently undergone significant nutritional interventions (e.g., dietary changes, supplementation) within the past three months prior to enrollment.
• \*Pregnancy or Lactation\*: Pregnant or lactating women, due to the need for specific nutritional considerations.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (1)

• Martinez Garcia MA, Maiz Carro L, Catalan Serra P. [Treatment of non-cystic fibrosis bronchiectasis]. Arch Bronconeumol. 2011 Dec;47(12):599-609. doi: 10.1016/j.arbres.2011.06.003. Epub 2011 Jul 28. Spanish.

  PMID: 21798654 BACKGROUND

Central Study Contacts

Hend Mohamed Sayed, Doctor

CONTACT

01098988712; hend.m.saleh@gmail.com

Ahmed mohamed Shadad, Doctor

CONTACT

0111117930; Shaddad_ahmad@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecture of chest disease at assiut university

Study Record Dates

• First Submitted: October 27, 2024
• First Posted: November 26, 2024
• Study Start: November 20, 2024
• Primary Completion: February 20, 2025
• Study Completion: March 20, 2025
• Last Updated: November 26, 2024

Record last verified: 2024-10