The Effects of Thoracic Manipulation on Peripheral Muscle Oxygenation

NCT06704373 | Completed

• 1 other identifier: Alev-Man24
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

Office workers spend 70-85% of their time sitting, which leads to postural disorders and musculoskeletal system diseases. Back pain is the most common health problem among office workers who need to sit. Studies have shown that spinal manipulation can help reduce back pain by decreasing the stiffness of spine segments associated with joint dysfunction. The primary aim of this study is to investigate the effects of thoracic spinal manipulation on peripheral oxygenation, pain, and disability of the back muscles in office workers with back pain, at acute, 10-day, and 4-week follow-up periods. The secondary aim is to evaluate whether the parameters have a significant relationship. The study will include volunteers aged 20-50 who are active office workers with no orthopedic, neurological, or psychological disorders, who have experienced back pain in the last 3 months, and who have a numerical pain scale score of at least 30 mm out of 100 mm. Participants will be randomized into the thoracic spinal manipulation and the control groups. Both groups will receive postural exercises. The thoracic spinal manipulation group will receive a single session of spinal manipulation, while the control group will only receive postural exercises. The study is expected to find significant improvement in peripheral muscle oxygenation, back pain, and disability scores following thoracic spinal manipulation. This study aims to contribute to the literature by focusing on how peripheral muscle oxygenation is affected by thoracic spinal manipulation.

Conditions

Back Pain; Spine Stiffness; Sedentary Behavior; Disability Physical

Keywords

moxy; spinal pain; sedantary; chiropractic

Outcome Measures

Primary Outcomes (1)

• Periferal muscle oxygen measurement

  Muscle oxygen levels will be measured using the Moxy Monitor. The Moxy Monitor is a mobile, non-invasive method for measuring SmO2. The device uses near-infrared spectroscopy (NIRS) technology and features a patented algorithm that measures hemoglobin and myoglobin in capillaries and muscle tissues with a wearable monitor. Moxy device measures real-time muscle oxygenation (SmO2) and total hemoglobin (tHb) levels by using near-infrared spectroscopy.

  Baseline, right after intervention, ten days after post intervention, four weeks after post intervention

Secondary Outcomes (3)

• Oswestry Disability Index

  Baseline, right after intervention, ten days after post intervention, four weeks after post intervention

• Neck Disability Index

  Baseline, right after intervention, ten days after post intervention, four weeks after post intervention

• Numeric Pain Scale

  Baseline, right after intervention, ten days after post intervention, four weeks after post intervention

Study Arms (2)

Manipulation group

EXPERIMENTAL

Thoracic spinal manipulation will be performed between the T1-T12 vertebral levels, based on the segment with movement limitations. The manipulation will be applied to the area of back pain using a high-velocity, low-amplitude thrust with a short-lever technique. Also, the same postural exercises that were given to the control group will be given.

Other: thoracal manipulation; Other: Exercise

Control Group

ACTIVE COMPARATOR

The postural exercises program will be given.

Other: Exercise

Interventions

thoracal manipulation OTHER

Thoracal manipulation will be applied only one session.

Manipulation group

Exercise OTHER

Both groups will perform the same postural exercises, which will be applied twice a week for 4 weeks. The intervention group will receive thoracic manipulation for one session.

Also known as: Postural Exercise

Control Group; Manipulation group

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Active desk-based office worker for the past 3 months
• Age between 20 and 50 years
• Back pain experience in the last 3 months
• Willing to participate in the study

You may not qualify if:

• Diagnosis of osteoporosis
• Presence of a newly formed fracture
• Recent trauma
• Cancer
• Osteomyelitis
• Hypermobility
• Ankylosing spondylitis
• Presence of an aneurysm
• Presence of vascular occlusion
• Malignancies

Sponsors & Collaborators

• Bahçeşehir University: lead

Study Sites (1)

Bahcesehir University

Beşiktaş, Istanbul, 34353, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Back Pain; Sedentary Behavior

Interventions

Exercise

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Alev Atasever, PT

  Bahcesehir University, Graduate Education Institute,Chiropractic Master of Science Program

  PRINCIPAL INVESTIGATOR

• Pelin Pişirici, PT, PhD

  Bahcesehir University, Faculty of Health Sciences

  STUDY DIRECTOR

• Berkay Eren Pejlivanoğlu, PT, PhD

  Bahcesehir University, Health Sciences Faculty, Physiotherapy and Rehabilitation

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor, PT, PhD

Model Details: Participants will be randomized into intervention (manipulation group) and control group.

Study Record Dates

• First Submitted: October 2, 2024
• First Posted: November 26, 2024
• Study Start: March 10, 2025
• Primary Completion: May 15, 2025
• Study Completion: May 30, 2025
• Last Updated: July 8, 2025

Record last verified: 2025-07

Locations

TU (1)