AI Chatbot for HPV Vaccine Literacy Among Caregivers in Japan

NCT06702423 | Completed

• 1 other identifier: UW231392
• Study Type: interventional
• Target: 804
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to learn if an innovative digital artificial intelligence (AI)-based communication tool works to enhance health literacy among Japanese caregivers regarding Human Papillomavirus (HPV) vaccination. Participants will:

• Answer a pre-intervention survey, get information regarding HPV vaccination from an AI-based chatbot or leaflet, and answer a post-intervention survey.
• Continue interacting with the chatbot or leaflet for two weeks.
• Answer a follow-up survey.

Conditions

Healthy

Keywords

HPV vaccine; AI; chatbot; Randomized Controlled Trial

Outcome Measures

Primary Outcomes (1)

• health literacy

  Health literacy related to HPV vaccination will be measured by changes in caregivers' scores on questions concerning facts about HPV vaccines and associated health information. The score consists of 7 factual questions, with total scores ranging from 0 to 7 based on the number of correct responses. Higher scores indicate greater literacy. This metric will be evaluated by determining the proportion of respondents who correctly answer these questions, reflecting their understanding and knowledge.

  2 weeks

Secondary Outcomes (1)

• decision-making

  2 weeks

Study Arms (2)

AI-based chatbot

EXPERIMENTAL

A chatbot that was developed using information related to HPV vaccines from authoritative sources such as the Japanese Ministry of Health, Labour, and Welfare, World Health Organization, Centers for Disease Control and Prevention, and other reputable public health organizations and validated survey questions from published research.

Behavioral: AI-based chatbot

Leaflet

ACTIVE COMPARATOR

A leaflet which is a publicly accessible HPV vaccination document prepared by the Ministry of Health, Labour, and Welfare.

Behavioral: Leaflet

Interventions

AI-based chatbot BEHAVIORAL

A tailored Japanese HPV vaccination chatbot.

AI-based chatbot

Leaflet BEHAVIORAL

A publicly accessible HPV vaccination leaflet prepared by the Ministry of Health, Labour, and Welfare.

Leaflet

Eligibility Criteria

• Age: 20 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• A nationally representative sample of female caregivers with daughters aged 12-18 who have not received any HPV vaccine.
• Those who have access to a smartphone or computer with internet connectivity to interact with experiment materials (chatbot or online leaflet).
• Those who provide informed consent and agree to participate in the study.

You may not qualify if:

• Those who need help reading through the participant information sheet, providing consent online, accessing experiment materials (chatbot or online leaflet), or answering surveys will be excluded. This may include people who do not have access to an online environment or people with severe cognitive impairments who cannot interact with the experiment materials. Also, those who have participated or are participating in similar studies regarding vaccination or experiments that utilize chatbots will be excluded.

Sponsors & Collaborators

• The University of Hong Kong: lead
• London School of Hygiene and Tropical Medicine: collaborator
• Nagasaki University: collaborator

Study Sites (1)

London School of Hygiene and Tropical Medicine

London, United Kingdom

Location

Study Officials

• Leesa Lin, PhD

  London School of Hygiene and Tropical Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 20, 2024
• First Posted: November 25, 2024
• Study Start: November 30, 2024
• Primary Completion: December 27, 2024
• Study Completion: December 27, 2024
• Last Updated: July 30, 2026

Record last verified: 2026-04

Locations

GB (1)