Leveraging Behavioral Science to Improve Medicine Optimization Conversations With Older Adults

NCT06698770 | Completed

• 1 other identifier: HUM00259517
• Study Type: interventional
• Target: 2,420
• Locations: 1 country
• Sites: 1

Brief Summary

Our online, survey-based experiment will include 2,400 adults who are 65-years and older (n=1,200 each from United States and Australia). Each participant will be asked to give their opinions on a hypothetical patient scenario that has been developed by our diverse team in partnership with our stakeholder organizations.This work is expected to significantly contribute to our understanding of how older adults make decisions about deprescribing medications.

Conditions

Deprescribing

Outcome Measures

Primary Outcomes (2)

• Preference regarding starting medication

  Response to statement, "Based on what you have read so far, what would you prefer to do with this diabetes medicine?" on a 6-point Likert scale with scale anchors 1=Strongly prefer not to start medicine and 6=Strongly prefer to start medicine

  1 year

• Stopping medication

  Response to statement, "Based on what you have read so far, what would you prefer to do with this diabetes medicine?" on a 6-point Likert scale with scale anchors 1=Strongly prefer not to continue and 6=Strongly prefer to stop

  1 year

Study Arms (4)

Start medication - Lower chance of future health problems

EXPERIMENTAL

Participants read a hypothetical scenario where a doctor recommends starting a new medication to lower their chances of experiencing significant health problems.

Other: Anticipated long-term use of medication; Other: Period re-evaluation of medication

Start medication - Higher risk without medication

EXPERIMENTAL

Participants read a hypothetical scenario where a doctor recommends starting a new medication because they could experience a higher risk of serious health problems without it

Other: Anticipated long-term use of medication; Other: Period re-evaluation of medication

Stop medication - Lack of benefit

EXPERIMENTAL

Participants read a hypothetical scenario where a doctor suggests stopping the medication due to a lack of benefit.

Other: Anticipated long-term use of medication; Other: Period re-evaluation of medication

Stop medication - Potential for harm

EXPERIMENTAL

Participants read a hypothetical scenario where a doctor suggests stopping the medication due to the potential for harm.

Other: Anticipated long-term use of medication; Other: Period re-evaluation of medication

Interventions

Anticipated long-term use of medication OTHER

In this hypothetical scenario, the doctor anticipates that the participant will take this medication for the rest of their life.

Start medication - Higher risk without medication; Start medication - Lower chance of future health problems; Stop medication - Lack of benefit; Stop medication - Potential for harm

Period re-evaluation of medication OTHER

In this hypothetical scenario, the doctor anticipates that the participant will take this medication for the rest of their life but will periodically re-evaluate the benefits and risks of the medication.

Start medication - Higher risk without medication; Start medication - Lower chance of future health problems; Stop medication - Lack of benefit; Stop medication - Potential for harm

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• years and older and resides in Australia or the United States

Sponsors & Collaborators

• University of Michigan: lead
• University of Sydney: collaborator

Study Sites (1)

University of Michigan

Ann Arbor, Michigan, 48109, United States

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Associate Professor of Clinical Pharmacy and Associate Chair, Clinical Pharmacy, College of Pharmacy

Study Record Dates

• First Submitted: November 19, 2024
• First Posted: November 21, 2024
• Study Start: November 1, 2024
• Primary Completion: January 30, 2025
• Study Completion: January 30, 2025
• Last Updated: September 26, 2025

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)