Multimodal Biocollection Linked to the French Register of Intracranial Aneurysms
bCAN
1 other identifier
interventional
1,100
1 country
26
Brief Summary
The purpose of the bCAN study is to create a prospective collection of multimodal data and human samples, linked to the French Intracranial Aneurysm Registry (FRAN). The aim of bCAN is to enable risk stratification of ruptured ICAs by redefining "intracranial aneurysm disease". The description of genotypically and phenotypically specific subgroups of cases will pave the way for improved patient management based on new diagnostic/prognostic strategies among AIC carriers, either in a familial context, or at the level of the general population.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Mar 2025
Typical duration for not_applicable
26 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 31, 2024
CompletedFirst Posted
Study publicly available on registry
November 14, 2024
CompletedStudy Start
First participant enrolled
March 25, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 25, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
March 25, 2027
May 29, 2026
April 1, 2026
2 years
October 31, 2024
May 26, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Performance of a predictive model allowing the classification of ICA subphenotypes
The performance of a predictive model allowing the classification of ICA subphenotypes will be analysed through the study of genetic results, quantitative features extracted from imaging and clinical data on rupture
36 months
Secondary Outcomes (4)
Characterization of arterial bifurcations
36 months
Characterization of aneurysmal sacs
36 months
Screening of genetic mutations
36 months
Correlation between genotypes and phenotypes
36 months
Study Arms (1)
ICA cases
OTHERAny adult patient consulting for a definite and typical bifurcation AIC authenticated on MRI and/or cerebral arteriography
Interventions
Eligibility Criteria
You may qualify if:
- Any adult patient consulting for a definite and typical bifurcation AIC authenticated on MRI and/or cerebral arteriography
- Aneurysm discovered less than a year ago, with initial imaging (MRI and/or CTA and DSA) available
- Written consent obtained for study participation
- Patient covered by a social security plan
- Index case: Any adult patient consulting for a definite and typical bifurcation ICA presenting at least one other case with ICA related (child, parent, brother, sister) detected by MRI with at least one Time of Flight (TOF) sequence.
- Family relatives: children, parents, brothers, sisters, of legal age, of patients with a family history of definite, typical bifurcation AIC (≥ 4 affected), Screening to be performed using MRI with at least a Time of Flight (TOF) sequence.
- Written consent to participate in the study
- Patient and relatives covered by a social security plan
You may not qualify if:
- Syndromic diagnosis known to cause ICA: Marfan syndrome, OSA with SMAD 3, Elhers Danlos syndrome type II and IV, Autosomal Dominant Cystic Fibrosis, Moya-Moya syndrome
- AIC with : Dissecting or fusiform, Associated with arteriovenous malformation, Blister-like, Mycotic
- Cerebral white matter pathology detected on MRI evoking : Col4a1 mutation
- Patient under guardianship or conservatorship
- Person under court protection
- Contraindication to an MRI scan
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Federation of Medical Specialtiescollaborator
- Nantes University Hospitallead
Study Sites (26)
Nantes University Hospital
Nantes, Loire-Atlantique, 44093, France
CHU Amiens
Amiens, France
CHU Angers
Angers, France
CHU Besançon
Besançon, France
CHU Bordeaux Hôpital Pellegrin
Bordeaux, France
CHU de Brest
Brest, France
CHU Caen-Normandie
Caen, France
CHU Clermont-Ferrand
Clermont-Ferrand, 63000, France
CHU Limoges
Limoges, France
APHM
Marseille, France
CHU de Montpellier
Montpellier, France
CHRU de Nancy
Nancy, France
GHU Paris - Hôpital Ste Anne
Paris, France
Hôpital Fondation Rothschild
Paris, France
Hôpital La Pitié Salpêtrière
Paris, France
Hôpital Lariboisière
Paris, France
CHU de Poitiers
Poitiers, France
CHU de Reims
Reims, France
CHU Rennes
Rennes, France
CHU de Rouen
Rouen, France
CHU St Etienne
Saint-Etienne, France
Hôpitaux Universitaires de Strasbourg
Strasbourg, France
Hôpital Foch
Suresnes, France
HIA Sainte-Anne
Toulon, France
CHU de Toulouse
Toulouse, France
CHRU Tours Hôpital Bretonneau
Tours, France
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Romain BOURCIER, MD
Nantes University Hospital
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- OTHER
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 31, 2024
First Posted
November 14, 2024
Study Start
March 25, 2025
Primary Completion (Estimated)
March 25, 2027
Study Completion (Estimated)
March 25, 2027
Last Updated
May 29, 2026
Record last verified: 2026-04