Research on Multimodal Multi-objective Integrated Machine Algorithm for Hip Replacement Surgery

NCT06689059 | Active Not Recruiting

• 1 other identifier: Xi'anHongHuiH
• Study Type: observational
• Target: 6,271
• Locations: 0 countries
• Sites: N/A

Brief Summary

Purpose: The aim of this study is to develop the Holistic Predictive Multi-Tasking Platform for Clinical Data Analysis (HoPreM) to accurately predict perioperative events following hip replacement surgery by integrating various types of data, including demographic, surgical, medical history, and laboratory information. The events targeted for prediction include acute kidney injury (AKI), blood transfusion requirements, 48-hour postoperative discharge (48hPOD), Intensive Care Unit (ICU) transfer, and length of hospital stay (LOS). Key Questions: Can the HoPreM platform reduce the risk of complications after hip replacement surgery? How accurate is the platform in predicting the specified perioperative events? Participants: Participants will include patients undergoing hip replacement surgery, aged 18 and above, with less than 10% missing values in their medical records. The collected data will be used to train and test the predictive models of the HoPreM platform. Study Procedures: Patient data will be collected from Xi'an Honghui Hospital, including creatinine values recorded before and after surgery. The HoPreM platform will process multimodal data, including demographic, surgical, medical history, and laboratory test data. Various ensemble learning algorithms (including XGBoost, random forest, LightGBM, and CatBoost) will be applied to predict different perioperative outcomes. Expected Outcomes: The HoPreM platform is expected to demonstrate its capability in predicting complications after hip replacement surgery, particularly acute kidney injury and blood transfusion requirements. Through SHAP value analysis, the study aims to reveal relationships between features and clinical outcomes, enhancing the model's interpretability and clinical utility. Contact Information: For any questions about this study or for more information, please contact the research team.

Conditions

Hip Replacement Surgery

Outcome Measures

Primary Outcomes (5)

• Acute Kidney Injury (AKI) Incidence

  AKI incidence will be assessed daily by comparing serum creatinine levels with the preoperative baseline. AKI incidence is determined by a ≥0.3 mg/dL increase in creatinine within 48 hours or a ≥50% increase within 7 days from baseline.

  From Day 1 to Day 7 post-surgery.

• Blood Transfusion Requirements

  To evaluate the need for blood transfusion postoperatively.

  From post-surgery Day 1 until discharge, up to a maximum of 40 days, assessed based on whether a blood transfusion was recorded during the hospital stay.

• 48-Hour Postoperative Discharge

  This outcome measure assesses whether the patient was discharged from the hospital within 48 hours following surgery.

  Within 48 hours post-surgery, assessed based on whether the patient was discharged from the hospital within this 48-hour period.

• ICU Transfer

  This outcome measure records whether the patient was transferred to the Intensive Care Unit (ICU) at any point during the hospital stay from post-surgery Day 1 until discharge, with a maximum observation period of 40 days.

  From post-surgery Day 1 until discharge, up to a maximum of 40 days, assessed based on whether an ICU transfer occurred during the hospital stay.

• Length of Hospital Stay

  This outcome measure calculates the total number of days the patient spends in the hospital from the time of admission until discharge, up to a maximum of 40 days.

  Total duration of hospital stay from admission to discharge, with a maximum observation period of 40 days.

Study Arms (1)

Hip Replacement Cohort

This cohort includes patients undergoing hip replacement surgery. The HoPreM platform is used for multi-task predictive analysis of perioperative complications, including AKI, blood transfusion requirements, postoperative discharge within 48 hours, ICU transfer, and length of hospital stay (LOS).

Other: Multimodal Data Integration and Multi-Task Learning

Interventions

Multimodal Data Integration and Multi-Task Learning OTHER

This study utilizes a multimodal data integration and multi-task learning approach to predict perioperative events after hip replacement surgery. By combining various data types, including demographics, surgical details, medical history, and lab results, the model enhances prediction accuracy for outcomes like AKI, blood transfusion needs, and ICU transfers. The use of ensemble learning algorithms such as CatBoost optimizes the platform's performance, offering a unique method for clinical decision support.

Hip Replacement Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study includes adult patients who have undergone hip replacement surgery at Xi'an Honghui Hospital. The study population is characterized by a diverse range of gender, age, and medical history, including patients with hypertension, diabetes, and other comorbidities. The inclusion criteria are: Age 18 years or older Missing values in medical records less than 10% Logically consistent medical records Availability of both preoperative and postoperative creatinine values The goal is to create a comprehensive dataset that represents the typical demographic of patients seen in clinical practice for hip replacement surgery.

You may qualify if:

• Patients who have undergone hip replacement surgery
• Age 18 years or older
• Missing values in medical records less than 10%
• Logically consistent medical records
• Availability of both preoperative and postoperative creatinine values

You may not qualify if:

• Non-hip replacement surgery patients (patients who did not undergo hip replacement surgery)
• Age less than 18 years
• Missing values greater than 10% in medical records
• Logical inconsistencies in the medical record
• No available preoperative or postoperative creatinine values

Sponsors & Collaborators

• Jingkun Liu: lead

Study Officials

• Jingkun Liu

  Honghui hospital, Xi'an Jiaotong University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Director

Study Record Dates

• First Submitted: November 6, 2024
• First Posted: November 14, 2024
• Study Start: October 24, 2024
• Primary Completion: October 31, 2024
• Study Completion: December 31, 2025
• Last Updated: November 18, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share