Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease

NCT06688968 | Recruiting

• 1 other identifier: RECHMPL23_0427
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 3

Brief Summary

The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and control subjects. The main questions it aims to answer are:

• A semi-structured interview to check the participants eligibility and gather demographic data.
• Neuropsychological tests and questionnaires will then be administered.
• A relative of the study participant will help complete questionnaires.

Conditions

Alzheimer Disease, Early Onset; Parkinsons Disease with Dementia; Non Pharmacological Intervention

Keywords

Non Pharmacological intervention; Alzheimer Disease, Early Onset; Parkinsons Disease with Dementia; Music Therapy

Outcome Measures

Primary Outcomes (1)

• Comparison of the specificities of musical engagement (i.e., music-related behaviors in daily life) in Alzheimer's disease, Parkinson's disease, and among a population of healthy old adults.

  Global score of informant version of the Music engagement Questionnaire (MusEQ-24) a 24 items questionnaire that delivers an overall score (ranging from 0 to 120) as well as a score for each of its 6 dimensions (ranging from 0 to 5) of musical engagement: Emotion, Daily life, Social, Response, Preferences and Identity. The higher the score, the greater the level of musical engagement.

  Baseline

Secondary Outcomes (26)

• The comparison of self- and hetero-questionnaires will be carried out within each group for each MUseQ24 dimension

  Baseline

• Comparison of global cognition between Alzheimer's, Parkinson's and healthy elderly groups

  Baseline

• Comparison of Executive Function between Alzheimer's, Parkinson's and healthy elderly groups

  Baseline

• Comparison of Episodic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups

  Baseline

• Comparison of Semantic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups

  Baseline

Study Arms (3)

patient with early-onset Alzheimer's disease (AD)

EXPERIMENTAL

patients followed up at the Centre Mémoire de Ressources et de Recherche (CMRR) of Montpellier, over 60 with Alzheimer's disease who have cognitive impairment based on an MMSE (Mini Mental State Examination) ≥ 20 and live at home with a relative

Behavioral: neuropsychologist interview; Behavioral: questionnaire

patients with parkinson's disease (PD)

ACTIVE COMPARATOR

patients followed up at the Center Expert Parkinson of Montpellier (CEPMo), over 60 with Parkinson's disease who have cognitive impairment based on an MMSE (Mini Mental State Examination) ≥ 20 and live at home with a relative

Behavioral: neuropsychologist interview; Behavioral: questionnaire

Healthy control

ACTIVE COMPARATOR

Subjects aged over 60, with no known neurodegenerative disease, living at home with a relative in the Hérault département.

Behavioral: neuropsychologist interview; Behavioral: questionnaire

Interventions

neuropsychologist interview BEHAVIORAL

It will take place either at the hospital or at the participant's home. This interview will consist of : * socio-demographic data collection * neuropsychological tests: * MMSE test (Mini Mental State Examination) cognitive function * RL-RI-16 test (16-item free recall/indexed recall test) * BECS test (Semantic knowledge assessment battery ) * WCST test (Wisconsin Card Sorting Test ) * Musical Cognition Test * Help from the participant's relative to answer certain questions, in particular the MuseEQ-24 questionnaire

Healthy control; patient with early-onset Alzheimer's disease (AD); patients with parkinson's disease (PD)

questionnaire BEHAVIORAL

The participant answers questionnaires: * Questionnaire MusEQ-24 self reported (Music Engagement Questionnaire) * Questionnaire BMRQ (Barcelona Reward Music Questionnaire) * Questionnaire SHAPS (Snaith-Hamilton Pleasure Scale) * Questionnaire LARS (Lille's Apathy Rating Scale) * Questionnaire PHQ-9 (Patient Health Questionnaire 9 items)

Healthy control; patient with early-onset Alzheimer's disease (AD); patients with parkinson's disease (PD)

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years and older
• French-speaking and volunteering for the study
• Living at home with a relative
• Biological diagnosis of probable Alzheimer's disease according to NINCDS-ADRDA criteria (McKhann et al., 1984)
• MMSE greater than or equal to 20
• Diagnosis of Idiopathic Parkinson's disease
• MMSE greater than or equal to 20

You may not qualify if:

• No known neurological pathologies (epilepsy and other non-degenerative CNS diseases) or psychiatric disorders (chronic psychosis and psychotic episodes)
• Autistic disorders
• History of stroke or head trauma
• Unstable medical condition (cancer)
• Subject unable to read and/or write
• Hearing impairment without hearing aids
• Refusal of consent after information
• Persons unable to give consent, research carried out in emergency situations, etc.)
• Non-affiliation with a social security scheme
• Person deprived of liberty (by judicial or administrative decision, or forced hospitalization)
• Person under legal protection (guardianship, curatorship, legal protection)

Sponsors & Collaborators

• University Hospital, Montpellier: lead
• Laboratoire EPSYLON: collaborator

Study Sites (3)

Montpellier Seniors' Association

Montpellier, Hérault, 34000, France

NOT YET RECRUITING

CHU de Montpellier - CEPMo

Montpellier, Hérault, 34295, France

RECRUITING

CHU de Montpellier - CMRR

Montpellier, Hérault, 34295, France

NOT YET RECRUITING

Related Publications (9)

• Bian X, Wang Y, Zhao X, Zhang Z, Ding C. Does music therapy affect the global cognitive function of patients with dementia? A meta-analysis. NeuroRehabilitation. 2021;48(4):553-562. doi: 10.3233/NRE-210018.

  PMID: 33967069 BACKGROUND

• Zhang Y, Cai J, An L, Hui F, Ren T, Ma H, Zhao Q. Does music therapy enhance behavioral and cognitive function in elderly dementia patients? A systematic review and meta-analysis. Ageing Res Rev. 2017 May;35:1-11. doi: 10.1016/j.arr.2016.12.003. Epub 2016 Dec 23.

  PMID: 28025173 BACKGROUND

• van der Steen JT, van Soest-Poortvliet MC, van der Wouden JC, Bruinsma MS, Scholten RJ, Vink AC. Music-based therapeutic interventions for people with dementia. Cochrane Database Syst Rev. 2017 May 2;5(5):CD003477. doi: 10.1002/14651858.CD003477.pub3.

  PMID: 28462986 BACKGROUND

• Platel H, Eustache ML, Coppalle R, Viard A, Eustache F, Groussard M, Desgranges B. Boosting Autobiographical Memory and the Sense of Identity of Alzheimer Patients Through Repeated Reminiscence Workshops? Front Psychol. 2021 Feb 15;12:636028. doi: 10.3389/fpsyg.2021.636028. eCollection 2021.

  PMID: 33679562 BACKGROUND

• Morris IB, Vasudevan E, Schedel M, Weymouth D, Loomis J, Pinkhasov T, Muratori LM. Music to One's Ears: Familiarity and Music Engagement in People With Parkinson's Disease. Front Neurosci. 2019 Jun 25;13:661. doi: 10.3389/fnins.2019.00661. eCollection 2019.

  PMID: 31293379 BACKGROUND

• Machado Sotomayor MJ, Arufe-Giraldez V, Ruiz-Rico G, Navarro-Paton R. Music Therapy and Parkinson's Disease: A Systematic Review from 2015-2020. Int J Environ Res Public Health. 2021 Nov 4;18(21):11618. doi: 10.3390/ijerph182111618.

  PMID: 34770129 BACKGROUND

• Loas G, Duru C, Godefroy O, Krystkowiak P. Hedonic deficits in Parkinson's disease: is consummatory anhedonia specific? Front Neurol. 2014 Mar 10;5:24. doi: 10.3389/fneur.2014.00024. eCollection 2014.

  PMID: 24653714 BACKGROUND

• Groussard M, Chan TG, Coppalle R, Platel H. Preservation of Musical Memory Throughout the Progression of Alzheimer's Disease? Toward a Reconciliation of Theoretical, Clinical, and Neuroimaging Evidence. J Alzheimers Dis. 2019;68(3):857-883. doi: 10.3233/JAD-180474.

  PMID: 30883343 BACKGROUND

• Belfi AM, Moreno GL, Gugliano M, Neill C. Musical reward across the lifespan. Aging Ment Health. 2022 May;26(5):932-939. doi: 10.1080/13607863.2021.1871881. Epub 2021 Jan 14.

  PMID: 33442987 BACKGROUND

MeSH Terms

Conditions

Alzheimer Disease

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• KARIM BENNYS, MD

  University Hospital, Montpellier

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mikaël Genguelou, PhD

CONTACT

06.04.45.37.94.; mikael.genguelou@univ-montp3.fr

KARIM BENNYS, MD

CONTACT

04.67.33.72.32; k-bennys@chu-montpellier.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Multicenter observational pilot study

Study Record Dates

• First Submitted: November 12, 2024
• First Posted: November 14, 2024
• Study Start: February 4, 2025
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: March 19, 2025

Record last verified: 2025-03

Locations

FR (3)