A Pospective, Single-arm, Multicenter Clinical Trial Evaluating Preoperative Neoadjuvant mFOLFOX6 Chemotherapy in Combination With PD1 Monoclonal Antibody in MSS/pMMR Locally Advanced Rectal Cancer

NCT06688786 | Active Not Recruiting

• 1 other identifier: XHEC-C-2024-179-2
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Preoperative neoadjuvant chemoradiotherapy can induce tumor regression and reduce the risk of postoperative recurrence, serving as the standard treatment for locally advanced rectal cancer. However, neoadjuvant radiotherapy may increase the risk of postoperative complications, proctitis, enteritis, and reduced anal function. Exploring radiation-free approaches to prevent the effects of radiotherapy toxicity on postoperative complications and quality of life is now a significant research focus. Neoadjuvant chemotherapy represents a promising approach in the neoadjuvant treatment of rectal cancer. Neoadjuvant chemotherapy avoids the impact of radiotherapy on organ function, reduces the incidence of postoperative anastomotic leakage, and is beneficial for long-term anal function preservation. However, its low tumor regression rate limits its application in the neoadjuvant treatment of rectal cancer. For patients with locally advanced rectal cancer, there is an urgent need for a new neoadjuvant treatment strategy that can both significantly improve tumor regression rates and reduce the risk of postoperative anastomotic leakage, and protect long-term anal function. PD-1 inhibitors are highly effective in treating microsatellite instability-high (MSI-H) colorectal cancer patients, but show poor efficacy in the 95% of patients with microsatellite stable (MSS) tumors. The challenge now is to find combination therapies that can convert tumors into an "immune-activated tumor," thereby enhancing the effectiveness of immunotherapy in MSS patients. Oxaliplatin and 5-fluorouracil have roles in releasing tumor antigen epitopes, activating CD8+ cells, and reshaping the immune microenvironment. Multiple clinical studies and animal experiments have shown that combining PD-1 antibodies with FOLFOX generates a synergistic effect, showing strong antitumor activity. This study evaluates the efficacy, safety, and impact on postoperative anal function of preoperative neoadjuvant treatment with FOLFOX chemotherapy combined with PD-1 inhibitors in patients with MSS-type advanced rectal cancer. The radiotherapy-free approach aims to avoid radiotherapy-related toxicity, offering significant potential to enhance the efficacy of neoadjuvant chemotherapy, improve long-term survival, and protect anal function.

Conditions

Locally Advanced Rectal Cancer (LARC)

Keywords

rectcal cancer; microsatellite stable; FOLFOX; neoadjuvant chemotherapy; PD-1 antibodies

Outcome Measures

Primary Outcomes (2)

• Pathological complete response

  Day 7 after surgery

• Major Pathological Response

  Day 7 after surgery

Secondary Outcomes (9)

• Tumor regression grade

  Day 7 after surgery

• Radiologic Response

  Preoperative evaluation

• Neoadjuvant rectal score

  Day 7 after surgery

• Postoperative complication

  Within 2 weeks post-surgery

• Disease free survival

  Three years after surgery

Study Arms (1)

Combinational treatment group

EXPERIMENTAL

neoadjuvant mFOLFOX6 chemotherapy combined with PD-1 inhibitor therapy

Drug: neoadjuvant mFOLFOX6 chemotherapy combined with PD-1 inhibitor therapy

Interventions

neoadjuvant mFOLFOX6 chemotherapy combined with PD-1 inhibitor therapy DRUG

Preoperative treatment with 4-6 cycles of mFOLFOX6 regimen combined with serplulimab

Combinational treatment group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Advanced (cT3-4NxM0 or cTxN+M0) rectal cancer with the lower tumor margin within 15 cm of the anal verge
• Histopathology confirmed adenocarcinoma with an pMMR/MSS genetic profile.
• Absence of bowel obstruction, or bowel obstruction relieved by proximal colostomy.
• Age: 18-75
• ECOG: 0-1
• No prior chemotherapy, radiotherapy, targeted therapy, or immunotherapy received.
• Female participants must be non-lactating, with a negative pregnancy test result.

You may not qualify if:

• Patients with distant metastasis
• History of receiving chemotherapy, radiotherapy, targeted therapy, or immunotherapy.
• Active autoimmune disease requiring systemic treatment within the 2 years prior to enrollment.
• History of other malignancies within the past 5 years, excluding cured cervical carcinoma in situ or basal cell carcinoma of the skin.
• History of HIV infection, or active chronic hepatitis B or C with high viral DNA copy numbers.
• Patients with active tuberculosis currently receiving anti-tuberculosis treatment or treated with anti-tuberculosis therapy within the past year prior to screening.
• Known or suspected allergy to the study drug or any study-related medications administered.
• Presence of severe cardiovascular or cerebrovascular disease.
• Within 14 days prior to the first dose, presence of a severe active or uncontrolled infection requiring systemic therapy, or unexplained fever \>38.5°C.
• Receiving systemic corticosteroid treatment or other immunosuppressive agents within 14 days prior to the first dose, or immunostimulants within 4 weeks.
• History of confirmed neurological or psychiatric disorders, including epilepsy or dementia.
• Refusal to sign the informed consent form.

Sponsors & Collaborators

• Xinhua Hospital, Shanghai Jiao Tong University School of Medicine: lead

Study Sites (1)

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, 200092, China

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 8, 2024
• First Posted: November 14, 2024
• Study Start: November 1, 2024
• Primary Completion: July 31, 2025
• Study Completion (Estimated): December 31, 2027
• Last Updated: January 27, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR

Locations

CN (1)