NCT06680024

Brief Summary

The goal of this clinical trial is to compare between outcome of inter-costal tube drainage and video assisted thoracoscopic surgery in management of patients with second stage empyema. It compares the outcome of both interventions in hospital stay, cost, wether need of decortication later on or not.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Nov 2024

Shorter than P25 for not_applicable

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 5, 2024

Completed
3 days until next milestone

First Posted

Study publicly available on registry

November 8, 2024

Completed
2 days until next milestone

Study Start

First participant enrolled

November 10, 2024

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 30, 2025

Completed
1 day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 31, 2025

Completed
Last Updated

November 8, 2024

Status Verified

September 1, 2024

Enrollment Period

9 months

First QC Date

November 5, 2024

Last Update Submit

November 7, 2024

Conditions

Outcome Measures

Primary Outcomes (3)

  • the length of hospital stay

    Comparison between both intercostal tube drainage and video assisted thoracoscopic surgery in management of patients with second stage empyema, we will compare the length of hospital stay of each group of patients

    From enrollment to 4 weeks

  • cost of treatment of the patients' in each group

    Comparison between both intercostal tube drainage and video assisted thoracoscopic surgery in management of patients with second stage empyema, we will compare cost of treatment of the patients' in each group

    4 weeks

  • number of participants with needs of decortication later on or not, assessed by the chest X-ray and CT chest.

    Comparison between both intercostal tube drainage and video assisted thoracoscopic surgery in management of patients with second stage empyema, we will compare with the chest X-ray and CT chest if there is residual empyema and whether the patients will need decortication later on or not

    4 weeks

Study Arms (2)

Intercostal tube

ACTIVE COMPARATOR

Intercostal tube as a primary intervention for treatment of second stage empyema

Procedure: Intercostal tube

Video assisted thoracoscope

ACTIVE COMPARATOR

Video assisted thoracoscopic evacuation as a primary intervention for treatment of nd stage empyema

Procedure: Video assisted thoracoscope

Interventions

Intercostal tube drainage as a first management of second stage empyema

Also known as: Chest tube
Intercostal tube

Video assisted thoracoscopic surgery as a first management for second stage empyema

Also known as: VATS
Video assisted thoracoscope

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Patients both adults and children diagnosed as Empyema thoracis in early stages based on clinical examination, imaging modalities and pleural fluid analysis

You may not qualify if:

  • Empyema due to carcinoma, terminally ill patients, patients with severe respiratory distress at admission, patients not fit for surgery, patients with co morbid diseases like cardiac disorders and immunosuppression.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Links

MeSH Terms

Interventions

Chest TubesThoracic Surgery, Video-Assisted

Intervention Hierarchy (Ancestors)

Surgical EquipmentEquipment and SuppliesThoracoscopyEndoscopyDiagnostic Techniques, SurgicalDiagnostic Techniques and ProceduresDiagnosisVideo-Assisted SurgeryMinimally Invasive Surgical ProceduresSurgical Procedures, OperativeThoracic Surgical Procedures

Central Study Contacts

Mostafa Sayed Khalaf

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, CARE PROVIDER
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Resident at cardiothoracic surgery department, sohag university hospitals

Study Record Dates

First Submitted

November 5, 2024

First Posted

November 8, 2024

Study Start

November 10, 2024

Primary Completion

July 30, 2025

Study Completion

July 31, 2025

Last Updated

November 8, 2024

Record last verified: 2024-09