Perioperative Impact of Physical Activity on Short- and Long-term Morbidity and Mortality

NCT06678360 | Recruiting

• 1 other identifier: PeriopIPA Karolinska
• Study Type: observational
• Target: 180,000
• Locations: 1 country
• Sites: 1

Brief Summary

Over 300 million surgeries are performed globally every year. Complications after surgery - infections, cardiovascular conditions, postoperative pulmonary complications and renal impairment - affect survival and quality of life. Age and co-morbidity are unmodifiable factors, contributing to increased risk of these perioperative complications. However, a modifiable risk factor is physical activity. This study aims to test if self reported physical activity is associated to lower risk of perioperative morbidity and mortality.

Conditions

General Surgery; Perioperative Complication; Perioperative Medicine; Physical Inactivity

Keywords

MET-scores; Physical activity; Perioperative mortality

Outcome Measures

Primary Outcomes (2)

• Mortality

  Death within the time frames described below

  Mortality will be recorded at 30, 60, 90 and 365 days after index surgery

• DAH30 (Days At Home alive at 30 days)

  DAH30: Patients who are hospitalized for 14 days postoperatively but are alive on day 30 will have DAH30=16. Patients who are hospitalized for five days, then discharged, but return after 10 days for an additional 11-day stay, will have DAH30=14. Anyone who dies within 30 days will have DAH30=0. This outcome measure is validated in several studies and has a significant advantage in that it correlates well with complications, even better than length of stay (LOS). We will further record DAH90 and DAH365, calculated as described above.

  30, 90 and 365 days after index surgery,

Secondary Outcomes (1)

• Length of stay

  One year after index surgery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients (equal to or over 18 years) undergoing elective non-cardiac surgery

You may qualify if:

• Adult patients (equal to or over 18 years) undergoing elective non-cardiac surgery at the two study sites, Karolinska University Hospital Solna and Karolinska University Hospital Huddinge

You may not qualify if:

• Patients under the age of 18, transplant, day surgery, acute surgery, anesthesia monitoring, brachy therapy and gamma knife interventions. In case of multiple surgeries, only the first will be included.

Sponsors & Collaborators

• Karolinska Institutet: lead

Study Sites (1)

Karolinska Institutet

Stockholm, Sweden

RECRUITING

MeSH Terms

Conditions

Sedentary Behavior; Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Max Bell, MD, PhD

  Karolinska Institutet

  PRINCIPAL INVESTIGATOR

• Arman Valadkhani, MD

  Karolinska Institutet

  STUDY CHAIR

Central Study Contacts

Max Bell, MD, PhD

CONTACT

+46708278533; max.bell@regionstockholm.se

Arman Valadkhani, MD

CONTACT

arman.valadkhani@regionstockholm.se

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD

Study Record Dates

• First Submitted: November 5, 2024
• First Posted: November 7, 2024
• Study Start: November 1, 2024
• Primary Completion: August 31, 2025
• Study Completion: December 1, 2025
• Last Updated: June 6, 2025

Record last verified: 2025-06

Locations

SE (1)