Characteristic Transcriptomic, Proteomic and Metabolomic Molecular Studies of Nasal Secretions From Chronic Rhinitis

NCT06678334 | Not Yet Recruiting

• 1 other identifier: 2024-SR-580
• Study Type: observational
• Target: 1,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

Chronic rhinitis is a common chronic nasal mucosal inflammatory disease. Its clinical symptoms and severity are diverse, mainly including allergic rhinitis, local allergic rhinitis, non-allergic rhinitis with hypereosinophilia syndrome and idiopathic rhinitis. All kinds of rhinitis have clinical symptoms such as nasal congestion, runny nose, sneezing, and nasal itching, but the causes are different. At present, the complicated diagnostic methods of different subtypes of chronic rhinitis are an important factor restricting the improvement of clinical diagnosis and treatment. Based on the found key markers of each subtype of chronic rhinitis, the establishment of a non-invasive classification diagnostic method of chronic rhinitis with nasal secretion as the core is of great practical significance for optimizing the existing clinical diagnosis system and improving the efficiency of clinical diagnosis

Conditions

Chronic Rhinitis

Outcome Measures

Primary Outcomes (1)

• The signature transcriptomic, proteomic, and metabolomic indicators or combinations of nasal secretions of different subtypes of chronic rhinitis

  The signature transcriptomic, proteomic, and metabolomic indicators or combinations of nasal secretions of different subtypes of chronic rhinitis, which have high sensitivity and specificity in the diagnosis of a specific chronic rhinitis.

  3 years

Study Arms (1)

chronic rhinitis

In this study, no additional intervention was performed on the patients. Only nasal secretions and blood samples were collected from patients with chronic rhinitis in our hospital.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All Patients in the First Affiliated Hospital, Nanjing Medical University and volunteering for this study

You may qualify if:

• Age 18-65 years old;
• Patients with chronic rhinitis in the Department of Otorhinolaryngology, the First Affiliated Hospital of Nanjing Medical University;
• Patients who are willing to provide specimens for free to promote the diagnosis of chronic rhinitis.

You may not qualify if:

• Patients received glucocorticoids, immunomodulatory drugs, antihistamines, and other treatments that may affect the study results within the past 1 month.
• Patients with unstable diseases (including severe asthma) and active immune system diseases;
• Smoking;
• Pregnant or lactating women; History of nasal surgery within 5.3 months;
• \. Patients with low compliance and refusing to accept specimen and questionnaire collection

Sponsors & Collaborators

• The First Affiliated Hospital with Nanjing Medical University: lead

Biospecimen

Retention: SAMPLES WITH DNA

Collection of plasma and nasal secretions

Study Officials

• Lei Cheng, PhD

  The First Affiliated Hospital, Nanjing Medical University

  STUDY DIRECTOR

Central Study Contacts

Lei Cheng, PhD

CONTACT

+8613776620807; chenglei@jsph.org.cn

Yanbing Chen MBBS, MBBS

CONTACT

+8615851875990; 1163259065@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, PhD

Study Record Dates

• First Submitted: November 6, 2024
• First Posted: November 7, 2024
• Study Start: November 6, 2024
• Primary Completion (Estimated): December 1, 2028
• Study Completion (Estimated): December 1, 2032
• Last Updated: November 7, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share