An Observational Study of Coronary Microvascular Disease of China

NCT06676137 | Recruiting

• 1 other identifier: HenanICE202410
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Non-obstructive coronary heart disease refers to patients with angina pectoris without significant narrowing of the epicardial vessels. Coronary microvascular disease(CMD) is a kind of non-obstructive coronary heart disease, and its clinical detection rate is increasing, seriously affecting the quality of life of patients, and increasing the risk of cardiovascular adverse events, but its mechanism has not been fully understood. This study will prospectively collect patients who meet the diagnosis of CMD, observe the development and outcome of the disease, and explore its occurrence and development mechanism.

Conditions

Coronary Microvascular Disease

Outcome Measures

Primary Outcomes (1)

• Establish a Registry of CMD patients in China

  5 years

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The patient had obvious symptoms of angina pectoris, but coronary angiography showed no obvious epicardial stenosis, and auxiliary examinations such as ultrasound, CTP,CMR, PET, SPECT, and coronary function examination indicate the presence of microcirculation dysfunction

You may qualify if:

• Angina symptoms
• Objective evidence of myocardial ischemia
• Coronary angiography was normal,irregular tube wall, or stenosis \<50%

You may not qualify if:

• People under the age of 18
• Non-cardiogenic chest pain and other heart conditions such as variant angina, cardiomyopathy, myocarditis or valvular heart disease

Sponsors & Collaborators

• Henan Institute of Cardiovascular Epidemiology: lead

Study Sites (1)

Fuwai central China cardiovascular hospotial

Zhengzhou, 450003, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood, saliva, stool and urine samples

MeSH Terms

Conditions

Microvascular Angina

Condition Hierarchy (Ancestors)

Angina Pectoris; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases

Study Officials

• muwei li, Ph.D

  Fuwai central China cardiovascular hospotial

  STUDY CHAIR

Central Study Contacts

Quan Guo

CONTACT

+8615670510031; xinyiguoquan@163.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 4, 2024
• First Posted: November 6, 2024
• Study Start: November 11, 2024
• Primary Completion (Estimated): October 10, 2028
• Study Completion (Estimated): October 10, 2029
• Last Updated: August 20, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)