SMART-r: Substance Monitoring and Active Relapse Tracking Repository

NCT06676059 | Recruiting

• 2 other identifiers: 10002094002094-DA
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 1

Brief Summary

Background: About 1.5 million adults in the US enter alcohol or substance use treatment programs each year. Unfortunately, more than half of patients do not finish their program. For those who start treatment, about 70% return to substance use within weeks or months after starting treatment. To discover why patients drop out of treatment and return to substance use - and what can be done about it - researchers need to learn more about people who use drugs and alcohol. Objective: To create a data repository by gathering survey and smartphone data from adults who use drugs and alcohol in order to conduct future research. Eligibility: Adults who have used drugs or alcohol in the past and have a Android smartphone. The researchers will recruit targeted demographics at different times throughout the duration of the study period. Design: Data will be collected for up to 6 months. All research activities will be online. Participants will download a smartphone app called TTRU-Curtis AWARE and keep it active on their phone. The app will run in the background and collect participant data, including: screen unlocks, duration of time the screen is on; apps used; words typed (except passwords); duration and time of phone calls; estimated location (exact location is not collected); and movement, such as how many steps are taken in a day. All personally identifying information is automatically removed before the data is stored (including phone numbers, names, or locations described in messages). Each day, participants will receive a text with a link to a survey. They will answer questions about their mood, behavior, and substance use from the day before. This survey should take less than 5 minutes to complete. Every 30 days, participants will complete a longer survey. They will answer questions about their personal relationships, risky behaviors, mood, substance use, and feelings. They can skip any questions they do not feel comfortable answering. These surveys should take about 30 minutes to complete. Participants may opt to allow researchers to access their social media posts.

Conditions

Alcoholism; Substance-Related Disorders

Keywords

Alcohol; Substance use; digital phenotyping

Outcome Measures

Primary Outcomes (1)

• SMARTr data repository

  The primary objective is to establish the NIDA-IRP Technology and Translational Research Unit (TTRU) Substance Monitoring and Active Relapse Tracking Repository (SMART-r) for collection, storage, and analysis of the human data from individuals who use substances.

  20 years

Study Arms (1)

Adults who use substances

Adults 18 years or older who use drugs or alcohol

Eligibility Criteria

• Age: 18 Years - 120 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults who have used drugs or alcohol in the past and have a Android smartphone. The researchers will recruit targeted demographics at different times throughout the duration of the study period.

You may qualify if:

• In order to be eligible to participate in the repository, an individual must meet all of the following criteria:
• Must understand and be willing to complete an online informed consent process.
• Be an adult aged 18 or older.
• Self-report alcohol or other drug use within the past 30 days.
• Have a smartphone as their primary mobile phone.
• Be willing to adhere to the procedures, such as downloading the AWARE app onto their smartphone and keeping it active throughout the data collection period, completing baseline questionnaires, daily diary EMAs, uploading historical conversational AI data, and/or follow-up surveys.
• Understand and write in English.
• Live in the United States.

You may not qualify if:

• An individual who meets any of the following criteria will be excluded from participation in this repository:
• \. Any impairment severe enough to preclude informed consent or valid self-report.

Sponsors & Collaborators

• National Institute on Drug Abuse (NIDA): lead

Study Sites (1)

National Institute on Drug Abuse

Baltimore, Maryland, 21224, United States

RECRUITING

Related Publications (28)

• Sinha R. New findings on biological factors predicting addiction relapse vulnerability. Curr Psychiatry Rep. 2011 Oct;13(5):398-405. doi: 10.1007/s11920-011-0224-0.

  PMID: 21792580 BACKGROUND

• Bauer LO. Predicting relapse to alcohol and drug abuse via quantitative electroencephalography. Neuropsychopharmacology. 2001 Sep;25(3):332-40. doi: 10.1016/S0893-133X(01)00236-6.

  PMID: 11522462 BACKGROUND

• Claus RE, Kindleberger LR. Engaging substance abusers after centralized assessment: predictors of treatment entry and dropout. J Psychoactive Drugs. 2002 Jan-Mar;34(1):25-31. doi: 10.1080/02791072.2002.10399933.

  PMID: 12003110 BACKGROUND

• Darke S, Campbell G, Popple G. Retention, early dropout and treatment completion among therapeutic community admissions. Drug Alcohol Rev. 2012 Jan;31(1):64-71. doi: 10.1111/j.1465-3362.2011.00298.x. Epub 2011 Mar 22.

  PMID: 21426420 BACKGROUND

• Evans E, Li L, Hser YI. Client and program factors associated with dropout from court mandated drug treatment. Eval Program Plann. 2009 Aug;32(3):204-12. doi: 10.1016/j.evalprogplan.2008.12.003. Epub 2008 Dec 11.

  PMID: 19150133 BACKGROUND

• Lejuez CW, Zvolensky MJ, Daughters SB, Bornovalova MA, Paulson A, Tull MT, Ettinger K, Otto MW. Anxiety sensitivity: a unique predictor of dropout among inner-city heroin and crack/cocaine users in residential substance use treatment. Behav Res Ther. 2008 Jul;46(7):811-8. doi: 10.1016/j.brat.2008.03.010. Epub 2008 Mar 28.

  PMID: 18466878 BACKGROUND

• Lopez-Goni JJ, Fernandez-Montalvo J, Arteaga A. Addiction treatment dropout: exploring patients' characteristics. Am J Addict. 2012 Jan-Feb;21(1):78-85. doi: 10.1111/j.1521-0391.2011.00188.x. Epub 2011 Dec 1.

  PMID: 22211350 BACKGROUND

• Odenwald M, Semrau P. Dropout among patients in qualified alcohol detoxification treatment: the effect of treatment motivation is moderated by Trauma Load. Subst Abuse Treat Prev Policy. 2013 Mar 21;8:14. doi: 10.1186/1747-597X-8-14.

  PMID: 23514277 BACKGROUND

• Epstein DH, Marrone GF, Heishman SJ, Schmittner J, Preston KL. Tobacco, cocaine, and heroin: Craving and use during daily life. Addict Behav. 2010 Apr;35(4):318-24. doi: 10.1016/j.addbeh.2009.11.003. Epub 2009 Nov 12.

  PMID: 19939575 BACKGROUND

• Epstein DH, Willner-Reid J, Vahabzadeh M, Mezghanni M, Lin JL, Preston KL. Real-time electronic diary reports of cue exposure and mood in the hours before cocaine and heroin craving and use. Arch Gen Psychiatry. 2009 Jan;66(1):88-94. doi: 10.1001/archgenpsychiatry.2008.509.

  PMID: 19124692 BACKGROUND

• Preston KL, Vahabzadeh M, Schmittner J, Lin JL, Gorelick DA, Epstein DH. Cocaine craving and use during daily life. Psychopharmacology (Berl). 2009 Dec;207(2):291-301. doi: 10.1007/s00213-009-1655-8. Epub 2009 Sep 24.

  PMID: 19777216 BACKGROUND

• Koob G, Kreek MJ. Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry. 2007 Aug;164(8):1149-59. doi: 10.1176/appi.ajp.2007.05030503.

  PMID: 17671276 BACKGROUND

• McHugh RK. Treatment of co-occurring anxiety disorders and substance use disorders. Harv Rev Psychiatry. 2015 Mar-Apr;23(2):99-111. doi: 10.1097/HRP.0000000000000058.

  PMID: 25747923 BACKGROUND

• Berenz EC, Coffey SF. Treatment of co-occurring posttraumatic stress disorder and substance use disorders. Curr Psychiatry Rep. 2012 Oct;14(5):469-77. doi: 10.1007/s11920-012-0300-0.

  PMID: 22825992 BACKGROUND

• Crosby R, Holtgrave DR, Stall R, Peterson JL, Shouse L. Differences in HIV risk behaviors among black and white men who have sex with men. Sex Transm Dis. 2007 Oct;34(10):744-8. doi: 10.1097/OLQ.0b013e31804f81de.

  PMID: 17565334 BACKGROUND

• Millett GA, Peterson JL, Wolitski RJ, Stall R. Greater risk for HIV infection of black men who have sex with men: a critical literature review. Am J Public Health. 2006 Jun;96(6):1007-19. doi: 10.2105/AJPH.2005.066720. Epub 2006 May 2.

  PMID: 16670223 BACKGROUND

• Levy ME, Wilton L, Phillips G 2nd, Glick SN, Kuo I, Brewer RA, Elliott A, Watson C, Magnus M. Understanding structural barriers to accessing HIV testing and prevention services among black men who have sex with men (BMSM) in the United States. AIDS Behav. 2014 May;18(5):972-96. doi: 10.1007/s10461-014-0719-x.

  PMID: 24531769 BACKGROUND

• Shuper PA, Joharchi N, Bogoch II, Loutfy M, Crouzat F, El-Helou P, Knox DC, Woodward K, Rehm J. Alcohol consumption, substance use, and depression in relation to HIV Pre-Exposure Prophylaxis (PrEP) nonadherence among gay, bisexual, and other men-who-have-sex-with-men. BMC Public Health. 2020 Nov 25;20(1):1782. doi: 10.1186/s12889-020-09883-z.

  PMID: 33256651 BACKGROUND

• Gebru NM, Benvenuti MC, Rowland BHP, Kalkat M, Chauca PG, Leeman RF. Relationships among Substance Use, Sociodemographics, Pre-Exposure Prophylaxis (PrEP) Awareness and Related Attitudes among Young Adult Men Who Have Sex with Men. Subst Use Misuse. 2022;57(5):786-798. doi: 10.1080/10826084.2022.2040030. Epub 2022 Feb 21.

  PMID: 35188880 BACKGROUND

• Crozier ME, Farokhnia M, Persky S, Leggio L, Curtis B. Relationship between self-stigma about alcohol dependence and severity of alcohol drinking and craving. BMJ Ment Health. 2023 Nov 22;26(1):e300852. doi: 10.1136/bmjment-2023-300852.

  PMID: 37993282 BACKGROUND

• Shiffman S. Ecological momentary assessment (EMA) in studies of substance use. Psychol Assess. 2009 Dec;21(4):486-97. doi: 10.1037/a0017074.

  PMID: 19947783 BACKGROUND

• Torous J, Onnela JP, Keshavan M. New dimensions and new tools to realize the potential of RDoC: digital phenotyping via smartphones and connected devices. Transl Psychiatry. 2017 Mar 7;7(3):e1053. doi: 10.1038/tp.2017.25.

  PMID: 28267146 BACKGROUND

• Jain SH, Powers BW, Hawkins JB, Brownstein JS. The digital phenotype. Nat Biotechnol. 2015 May;33(5):462-3. doi: 10.1038/nbt.3223. No abstract available.

  PMID: 25965751 BACKGROUND

• Barnett I, Torous J, Staples P, Sandoval L, Keshavan M, Onnela JP. Relapse prediction in schizophrenia through digital phenotyping: a pilot study. Neuropsychopharmacology. 2018 Jul;43(8):1660-1666. doi: 10.1038/s41386-018-0030-z. Epub 2018 Feb 22.

  PMID: 29511333 BACKGROUND

• Boukhechba M, Chow P, Fua K, Teachman BA, Barnes LE. Predicting Social Anxiety From Global Positioning System Traces of College Students: Feasibility Study. JMIR Ment Health. 2018 Jul 4;5(3):e10101. doi: 10.2196/10101.

  PMID: 29973337 BACKGROUND

• Giorgi S, Yaden DB, Eichstaedt JC, Ungar LH, Schwartz HA, Kwarteng A, Curtis B. Predicting U.S. county opioid poisoning mortality from multi-modal social media and psychological self-report data. Sci Rep. 2023 Jun 3;13(1):9027. doi: 10.1038/s41598-023-34468-2.

  PMID: 37270657 BACKGROUND

• Son Y, Clouston SAP, Kotov R, Eichstaedt JC, Bromet EJ, Luft BJ, Schwartz HA. World Trade Center responders in their own words: predicting PTSD symptom trajectories with AI-based language analyses of interviews. Psychol Med. 2023 Feb;53(3):918-926. doi: 10.1017/S0033291721002294. Epub 2021 Jun 22.

  PMID: 34154682 BACKGROUND

• Meyerhoff J, Liu T, Stamatis CA, Liu T, Wang H, Meng Y, Curtis B, Karr CJ, Sherman G, Ungar LH, Mohr DC. Analyzing text message linguistic features: Do people with depression communicate differently with their close and non-close contacts? Behav Res Ther. 2023 Jul;166:104342. doi: 10.1016/j.brat.2023.104342. Epub 2023 May 27.

  PMID: 37269650 BACKGROUND

MeSH Terms

Conditions

Alcoholism; Substance-Related Disorders

Condition Hierarchy (Ancestors)

Alcohol-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Officials

• Brenda L Curtis, Ph.D.

  National Institute on Drug Abuse (NIDA)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jessica E Hemmons

CONTACT

Not Listed; jessie.hemmons@nih.gov

Brenda L Curtis, Ph.D.

CONTACT

(443) 740-2126; brenda.curtis@nih.gov

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 5, 2024
• First Posted: November 6, 2024
• Study Start (Estimated): April 21, 2026
• Primary Completion (Estimated): December 31, 2044
• Study Completion (Estimated): December 31, 2044
• Last Updated: April 16, 2026

Record last verified: 2026-04-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)