Clinical Trial to Treat Stage IV Cancer Patients

NCT06674538 | Enrolling By Invitation Phase 1 DMC FDA Drug

• 1 other identifier: Moonshot protocol #2024-01
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research is to study the safety and effectiveness of investigational antibodies attacking certain areas on the surface of cancer cells so that the body can kill the cancer cells. The antibodies will be made in a laboratory from cells taken from each subject's tumor so they will be made specifically per subject. The first step is to take blood and tumor samples so that the laboratory can produce antibodies specific to each subject's tumor. During this process, the study team will identify specific areas on the cancer cells that are not normally present in healthy cells so that the antibodies can find the cancer cells that should be destroyed. The second step is to deliver the antibodies to each subject through a series of infusions.

Conditions

Soft Tissue Cancer

Keywords

Stage IV cancer; patient-specific mutated cell surface proteins; chimeric antibodies

Outcome Measures

Primary Outcomes (1)

• Safety: Frequency of Grade III or greater adverse events

  Frequency of Grade III or greater adverse events

  From first dose of treatment through endpoint evaluation at 6 months

Study Arms (1)

Treatment group

EXPERIMENTAL

Treatment with multiple patient-specific mutated cell surface proteins with chimeric antibodies

Drug: Moonshot antibodies

Interventions

Moonshot antibodies DRUG

Chimeric antibodies

Treatment group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjects 18 years of age or older who have biopsy proven cancer. The following types of malignancy will be eligible:
• Stage IV cancer of the following types: breast cancer, colon cancer, esophageal cancer, kidney cancer, lung cancer, lymphoma, melanoma, ovarian cancer, pancreatic cancer, bladder, urothelial carcinoma, head and neck cancers, prostate cancer, sarcomas, and stomach cancer.
• Subjects who have refractory or progressive disease after at least 1 line of systemic treatment or who have declined additional curative standard of care therapy(ies).
• Subjects willing to consent to obtaining a blood sample and archived tumor tissue for genomic extraction and amplification. If archived tumor tissue is not available, a new biopsy sample will be required. If sequencing was previously completed under Moonshot Antibodies IRB protocol #20233336 or completed on the patient's tumor as part of clinical care, these results and samples may be used and duplicative tumor sequencing will not be necessary.
• Subjects must have measurable disease as defined per the Response Evaluation Criteria in Solid Tumor (RECIST) at the time of biopsy. Archived tumor must be available or tumor must be accessible for biopsy.
• Karnofsky Score must be ≥ 60
• Hematological:
• ANC (Absolute neutrophil count) ≥ 1000/µl (unsupported)
• Platelets ≥ 100,000/µl (can be transfused)
• Hemoglobin \> 8 g/dL (can be transfused)
• Renal: Serum creatinine ≤ 1.5 x upper limit of institutional normal.
• Adequate liver function must be demonstrated, defined as:
• Total bilirubin ≤ 1.5 x upper limit of normal (ULN)
• ALT (SGPT) ≤ 3 times upper limit of normal (ULN)
• AST (SGOT) ≤ 3 times upper limit of normal (ULN)

You may not qualify if:

• Insufficient tumor tissue for genome sequencing.
• Known human immunodeficiency virus infection.
• Subjects who have received any cytotoxic treatment within 3 weeks of antibody treatment.
• Subjects who have received any radiotherapy to the tumor biopsy sample site within the last 14 days (radiation may be included in treatment decision after biopsy).
• Subjects who have received live vaccines within 30 days prior to the first dose of trial treatment and while participating in the trial. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster, yellow fever, rabies, BCG, and typhoid vaccine.
• Subjects who are currently receiving or have received systemic therapeutic corticosteroids ≤2 weeks prior to starting treatment.
• Subjects receiving any investigational drug concurrently.
• Subjects with chronic active autoimmune diseases undergoing treatment.
• Subjects who have had prior organ transplant.
• Subjects who have developed allergic responses to chimeric antibodies.
• Subjects with symptomatic known brain metastases \< 4 weeks from radiation treatment
• Subjects with significant (\>Grade 2 toxicity) renal, cardiac, pulmonary, hepatic or other organ dysfunction.
• Subjects with secondary cancers that require systemic treatment.
• Subjects that are pregnant or breastfeeding.
• Subjects with uncontrolled serious infections or a life-threatening illness (unrelated to tumor) including, but not limited to symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia.

Sponsors & Collaborators

• Moonshot Antibodies: lead

Study Sites (1)

Penn State Cancer Institute

Hershey, Pennsylvania, 17033, United States

Location

MeSH Terms

Conditions

Sarcoma; Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms, Connective and Soft Tissue; Neoplasms by Histologic Type

Study Officials

• David Krag, MD

  Moonshot Antibodies

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 4, 2024
• First Posted: November 5, 2024
• Study Start: December 30, 2024
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2029
• Last Updated: September 22, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will share
• Time Frame: After data analysis and IND closure. End date is undetermined at this time.
• Access Criteria: This is undetermined at this time.

Locations

US (1)