HIV and Multi-Drug Resistant Tuberculosis: a Study on Clinical Outcomes

NCT06671808 | Completed

• 1 other identifier: HIVTB2024
• Study Type: observational
• Target: 222,128
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the relationship between HIV infection and multi-drug resistant tuberculosis (MDR-TB) among affected individuals in Zahedan, Iran. It will involve a detailed analysis of patient demographics, clinical characteristics, and treatment outcomes to enhance understanding of this co-infection. The findings may inform better treatment strategies and healthcare policies for managing these diseases in similar populations.

Conditions

HIV Infection; MDR-TB

Outcome Measures

Primary Outcomes (1)

• Prevalence of Multi-Drug Resistant Tuberculosis (MDR-TB) in HIV-Positive Patients

  This study aims to determine the prevalence of multi-drug resistant tuberculosis (MDR-TB) among patients co-infected with HIV. Data will be collected from various studies included in the meta-analysis, focusing on the incidence rates of MDR-TB in this population. The analysis will provide insights into the challenges faced in treating HIV-positive individuals with MDR-TB and highlight the need for targeted interventions.

  Data collected over the course of the studies from 2006 to 2018.

Interventions

Examination of HIV Infection in Patients with Multi-Drug Resistant Tuberculosis (MDR-TB) OTHER

This meta-analysis examines the impact of HIV infection on the prevalence and outcomes of multi-drug resistant tuberculosis (MDR-TB) among affected populations. The analysis synthesizes data from multiple studies conducted across various countries, focusing on the correlation between HIV co-infection and MDR-TB rates, treatment outcomes, and demographic factors. The findings aim to enhance understanding of the complex interactions between HIV and MDR-TB, ultimately informing clinical practices and public health strategies.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult individuals (aged 18 years and older) diagnosed with both HIV infection and multi-drug-resistant tuberculosis (MDR-TB). This meta-analysis synthesizes data from various studies conducted across multiple countries, including Brazil, the USA, Canada, India, Ethiopia, and several others. The population includes a diverse cohort of patients, reflecting various demographic characteristics such as age, sex, and geographical location. The studies included in this meta-analysis feature participants with confirmed diagnoses of HIV and MDR-TB, with a focus on understanding the co-infection dynamics, treatment outcomes, and associated health challenges. Data extraction from these studies provides insight into the prevalence and impact of MDR-TB among HIV-positive patients, highlighting the importance of tailored

You may qualify if:

• Adults (aged 18 years and older) diagnosed with both HIV and multi-drug-resistant tuberculosis (MDR-TB).
• Studies published in peer-reviewed journals.
• Studies that provide data on the co-occurrence of HIV and MDR-TB.
• Participants from diverse geographical regions to enhance generalizability.
• Studies with clear definitions of MDR-TB according to WHO guidelines.

You may not qualify if:

• Studies that focus solely on drug-susceptible tuberculosis without MDR-TB.
• Studies involving pediatric populations (under 18 years of age).
• Non-original research such as reviews, editorials, and commentaries.
• Studies lacking sufficient data on the co-occurrence of HIV and MDR-TB.
• Studies that do not adhere to ethical guidelines for human subjects or lack appropriate ethical approvals.

Sponsors & Collaborators

• Zahedan University of Medical Sciences: lead

Study Sites (1)

Zahedan University of Medical Sciences

Zahedan, Sistan and Baluchestan, 98167-43463, Iran

Location

MeSH Terms

Conditions

HIV Infections; Tuberculosis, Multidrug-Resistant

Condition Hierarchy (Ancestors)

Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases; Tuberculosis; Mycobacterium Infections; Actinomycetales Infections; Gram-Positive Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: November 1, 2024
• First Posted: November 4, 2024
• Study Start: May 15, 2024
• Primary Completion: August 22, 2024
• Study Completion: September 3, 2024
• Last Updated: November 4, 2024

Record last verified: 2024-11

Locations

IR (1)