Correlation of Blood Serum Renalase and Microcirculation Obstruction in Patients with Acute Myocardial Infarction After Primary Percutaneous Coronary Intervention

NCT06669520 | Recruiting

• 1 other identifier: K 24655
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This research will explore the association between blood serum renalase and microcirculation obstruction in patients with acute myocardial infarction (AMI) after primary percutaneous coronary intervention (PCI). The investigators aim to identify potential risk factors for microcirculation obstruction in AMI patients after PPCI.

Conditions

Acute Myocardial Infarction

Outcome Measures

Primary Outcomes (1)

• Number of Participants with Microvascular Obstruction Assessed by Contrast-Enhanced Magnetic Resonance Imaging 3-7 Days After Percutaneous Coronary Intervention.

  Microvascular obstruction (MVO) was qualitatively recognized as a subendocardial lack of enhancement at first-pass perfusion (FPP) sequences and as a hypointense region within the hyperintense infarcted area at early gadolinium enhancement (EGE) and late gadolinium enhancement (LGE) sequences.

  3-7 days after PPCI

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will include 200 patients diagnosed with acute myocardial infarction (AMI) who will undergo primary percutaneous coronary intervention (PCI) at the Third Xiangya Hospital of Central South University, from August 2024 to August 2025.

You may qualify if:

• Age ≥ 18 years;
• STEMI symptom onset time \< 12 hours;
• STEMI symptom onset time 12-48 hours with persistent ischemic symptoms, hemodynamic instability, or life-threatening ventricular arrhythmias;
• High-risk NSTEMI;
• Emergency PCI;
• Voluntary informed consent.

You may not qualify if:

• Non-obstructive acute myocardial infarction;
• Severe chronic kidney disease (defined as estimated glomerular filtration rate \< 20 mL/min per 1.73 m²);
• Life expectancy \< 1 year;
• Pregnant or planning to become pregnant;
• Emergency PCI failure.

Sponsors & Collaborators

• The Third Xiangya Hospital of Central South University: lead

Study Sites (1)

The Third Xiangya Hospital of Central South University

Changsha, Hunan, 410013, China

RECRUITING

Related Publications (1)

• Chen Y, Li R, Fu R, Zhao L, Sheng Z, Xu K, Liu J, Huang W, Wen J, Zeng L, Ou Z, Jiang Z, Liu Y, Wang Y, Jiang W, Li X. Association between periprocedural change in serum renalase and microvascular obstruction in patients with STEMI after primary percutaneous coronary intervention: protocol for the ReMVOS prospective cohort study. BMJ Open. 2025 Nov 28;15(11):e110045. doi: 10.1136/bmjopen-2025-110045.

  PMID: 41314850 DERIVED

Central Study Contacts

Weihong Jiang

CONTACT

（86）13786113632; jiangweihongdoc@163.com

Ye Chen

CONTACT

（86）18674319338; chenye1223@126.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 29, 2024
• First Posted: November 1, 2024
• Study Start: August 1, 2024
• Primary Completion: October 1, 2025
• Study Completion: October 1, 2025
• Last Updated: November 1, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)