Acute Effects of Meteorological Factors and Air Pollution on Cardiovascular Health

NCT06663267 | Recruiting

• 1 other identifier: AH-2023-005
• Study Type: observational
• Target: 350,000
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to analyze the acute effects of meteorological factors and air pollution on cardiovascular system. The main question it aims to answer is:

1. 1.How do meteorological factors and air pollution affect cardiovascular system?
2. 2.What is the interaction between meteorological factors and air pollution on cardiovascular system?
3. 3.Provide their health data obtained in physical examination, including but not limited to blood pressure, blood routine, urine routine and B-ultrasound.
4. 4.agree that the research team will use their personal identification number, gender, age, education level and other information for statistical analysis of the data.

Conditions

Cardiovascular System; Health

Keywords

Cardiovascular System; Air Pollution Exposure; Acute effect; Weather

Outcome Measures

Primary Outcomes (2)

• Troponin

  Troponin data were obtained by blood biochemical detection data recorded in the diagnosis and treatment system, with unit of µg/L.

  The troponin data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

• Blood pressure

  Blood pressure data were obtained from the diagnosis and treatment record system and analyzed by standard sphygmomanometer, with unit of mmHg.

  The blood pressure data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

Secondary Outcomes (8)

• Left ventricular ejection fraction（LVEF）

  The left ventricular ejection fraction（LVEF）data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

• White cell count

  The white cell count data were tested at baseline 3 months before exposure to meteorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

• Controlled Attenuation Parameter（CAP）

  The Controlled Attenuation Parameter（CAP）data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

• ST segment of electrocardiogram

  The ST segment of electrocardiogram were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

• Degree of coronary artery stenosis

  The degree of coronary artery stenosis data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

Study Arms (4)

High Temperature Group

Participants experiencing temperatures above the 90th percentile for the region, as recorded during the summer months. Temperature data are sourced from local meteorological statio

Other: NOT

Low Temperature Group

Includes participants from areas where winter temperatures are below the 10th percentile, based on historical weather data from local meteorological observations

Other: NOT

High Pollution Group

Participants in this group are those exposed to high levels of air pollutants

Other: NOT

Low Pollution Group

This cohort consists of individuals living in areas with air pollutant levels consistently below the national air quality standards

Other: NOT

Interventions

NOT OTHER

This retrospective cohort study involves no new interventions. It analyzes existing health data collected from subjects exposed to varying atmospheric conditions to assess impacts on health outcomes.

High Pollution Group; High Temperature Group; Low Pollution Group; Low Temperature Group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

1. Target population: adults who have been recorded at least three times in the physical examination database will be included in this study. This requirement aims to ensure that the participants\' health status can be fully evaluated historically, and then to study the changes of various health indicators over time. 2. Sample source and recruitment: Participants will be selected from the routine physical examination database of several hospital physical examination centers in Zhejiang, Henan, Anhui, Guizhou and other provinces.

You may qualify if:

• ·Relevant records in the physical examination database shall be ≥3 times
• ·≥18 years old

You may not qualify if:

• Relevant records in the physical examination database shall be ≥３times
• Serious heart and lung diseases
• Malignant tumors
• Serious mental illness in the past

Sponsors & Collaborators

• The Affiliated Hospital of Hangzhou Normal University: lead

Study Sites (1)

MingWei Wang

Hanzhou, Zhejiang, 310000, China

RECRUITING

Related Publications (3)

• Clement DL, De Buyzere ML, De Bacquer DA, de Leeuw PW, Duprez DA, Fagard RH, Gheeraert PJ, Missault LH, Braun JJ, Six RO, Van Der Niepen P, O'Brien E; Office versus Ambulatory Pressure Study Investigators. Prognostic value of ambulatory blood-pressure recordings in patients with treated hypertension. N Engl J Med. 2003 Jun 12;348(24):2407-15. doi: 10.1056/NEJMoa022273.

  PMID: 12802026 BACKGROUND

• McCarron P, Smith GD, Okasha M, McEwen J. Blood pressure in young adulthood and mortality from cardiovascular disease. Lancet. 2000 Apr 22;355(9213):1430-1. doi: 10.1016/S0140-6736(00)02146-2.

  PMID: 10791531 BACKGROUND

• Tandon S, Grande AJ, Karamanos A, Cruickshank JK, Roever L, Mudway IS, Kelly FJ, Ayis S, Harding S. Association of Ambient Air Pollution with Blood Pressure in Adolescence: A Systematic-review and Meta-analysis. Curr Probl Cardiol. 2023 Feb;48(2):101460. doi: 10.1016/j.cpcardiol.2022.101460. Epub 2022 Oct 18.

  PMID: 36265590 BACKGROUND

Central Study Contacts

Mingwei W Wang, PhD

CONTACT

18758871517; wmw990556@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 12, 2024
• First Posted: October 29, 2024
• Study Start: November 1, 2024
• Primary Completion (Estimated): May 1, 2027
• Study Completion (Estimated): May 1, 2028
• Last Updated: October 29, 2024

Record last verified: 2024-10

Locations

CN (1)