EVENTIDE
Exploiting Human Microbiota-associated in Vivo Models for Mechanistic Studies to Understand the Benefits of Dietary Fibre Supplementation in Patients With Prostate Cancer
Sponsor study identifier
Secondary identifiers
OTHER_GRANT · NHS Grampian Charity, UK
observational
6
1 country
1
Study Start
November 15, 2024
Actual (reported)Primary Completion
December 31, 2024
Actual (reported)Study Completion
October 31, 2025
Actual (reported)The digestive tract (large intestine) contains microorganisms that digest complex carbohydrates in food to produce chemical substances which are beneficial to human health. The population of these microorganisms in faeces (stool samples) could be used to diagnose the health status of a person and this can be changed with the use of antibiotics, diet, radiotherapy or infection. Dietary fibre supplements can help provide nutrients for the beneficial bacteria from the large intestine to produce useful chemicals that may delay growth or even shrink prostate cancer in patients. The investigators will feed mice diets containing several dietary fibres (including inulin, pectin and hemp hull) and also faeces from healthy male human volunteers over 60 years old to see what effect this has on the makeup of the bacteria in their gut and the resulting beneficial metabolites (chemicals). For this work, the research team need to obtain four to six fresh faecal samples on the same day, so that these can be mixed fresh and stored for use as faecal microbiota transplant (FMT) in the mice. The researchers will then test how altering the gut microorganisms with faeces and dietary fibre supplements can influence the growth of prostate cancer cell tumours in mice. The investigators expect to see an effect of the fibres in promoting beneficial bacteria and in shrinking the tumours. This work will allow the investigators to identify dietary fibres that could be used in nutritional therapies for management of prostate cancer patients in future.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 31, 2025
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 24, 2024
Actual (reported)October 28, 2024
Actual (reported)November 15, 2024
Actual (reported)December 31, 2024
Actual (reported)October 31, 2025
Actual (reported)16S rRNA gene sequencing
The investigators will extract bacterial DNA for 16S rRNA gene sequencing analysis to compare the baseline microbial community of volunteers to that of the mice microbiota after faecal microbiota transplantation.
December 2024 to October 2025
The investigators will also invite men over 60 years who are staff at the University of Aberdeen, via All Staff mailing lists (including SMMSN and Rowett) and the University's weekly News Update and small ads.
University of Aberdeen
Aberdeen, Scotland, AB25 2ZD, United Kingdom
Routy B, Lenehan JG, Miller WH Jr, Jamal R, Messaoudene M, Daisley BA, Hes C, Al KF, Martinez-Gili L, Puncochar M, Ernst S, Logan D, Belanger K, Esfahani K, Richard C, Ninkov M, Piccinno G, Armanini F, Pinto F, Krishnamoorthy M, Figueredo R, Thebault P, Takis P, Magrill J, Ramsay L, Derosa L, Marchesi JR, Parvathy SN, Elkrief A, Watson IR, Lapointe R, Segata N, Haeryfar SMM, Mullish BH, Silverman MS, Burton JP, Maleki Vareki S. Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial. Nat Med. 2023 Aug;29(8):2121-2132. doi: 10.1038/s41591-023-02453-x. Epub 2023 Jul 6.
Smits LP, Bouter KE, de Vos WM, Borody TJ, Nieuwdorp M. Therapeutic potential of fecal microbiota transplantation. Gastroenterology. 2013 Nov;145(5):946-53. doi: 10.1053/j.gastro.2013.08.058. Epub 2013 Sep 7.
Samples will be stored until the study has been completed and then for further 5 years to allow for potential additional analysis in future ethically reviewed and approved studies. Anonymised 16S rRNA gene-based gut microbiota profiling sequence data will be uploaded to a publicly accessible data repository prior to publication.
Anne E Kiltie, MA, DN, DSc
University of Aberdeen
6 participants (actual enrollment reported by the registry).
First Submitted
October 24, 2024
First Posted
October 28, 2024
Study Start
November 15, 2024
Actual (reported)Dose De-escalation in Prostate Radiotherapy Using an MR-Linac in Two Fractions
Contact the study team to confirm eligibility.
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Blanco-Perez F, Steigerwald H, Schulke S, Vieths S, Toda M, Scheurer S. The Dietary Fiber Pectin: Health Benefits and Potential for the Treatment of Allergies by Modulation of Gut Microbiota. Curr Allergy Asthma Rep. 2021 Sep 10;21(10):43. doi: 10.1007/s11882-021-01020-z.
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Then CK, Paillas S, Wang X, Hampson A, Kiltie AE. Association of Bacteroides acidifaciens relative abundance with high-fibre diet-associated radiosensitisation. BMC Biol. 2020 Aug 19;18(1):102. doi: 10.1186/s12915-020-00836-x.
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Primary Completion
December 31, 2024
Actual (reported)Study Completion
October 31, 2025
Actual (reported)Last Updated
April 30, 2026
Record last verified: 2024-12
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