The Effects of Exercise Intervention on Skeletal Muscle and Other Organs in Aged Population and the Discovery of Associated Circulating Biomarkers

NCT06660706 | Recruiting

• 1 other identifier: NYCU112162AF
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This project aims to investigate the intricate interplay between skeletal muscle and adipose tissue during the aging process by integrating human studies. Utilizing interventional research and randomized trials combined with examining blood samples from elderly individuals engaged in exercise, we aim to investigate the effects of exercise on muscle health and explore the underlying mechanisms of muscle aging and related biomarkers. Interdisciplinary research allowed us to investigate the systemic impact of exercise on muscles. This approach allowed us to gain a better understanding of the interconnectedness of skeletal muscle and adipose tissue in the aging process and devise efficient strategies to reverse age-related changes. These findings hold promise for promoting a future society where long and healthy life is achievable for all.

Conditions

Age-related Functional Decline

Keywords

aging; muscle health; body composition

Outcome Measures

Primary Outcomes (1)

• Change in Physical performance

  Change in hand-grip strength (kg), or six-meter walking speed (m/s), or 5 times sit to stand test from baseline to 6 months in all participants

  baseline, 6 month

Secondary Outcomes (10)

• Change in DHEA-S

  baseline, 6 month

• Change in IGF-1

  baseline, 6 month

• Change in hs-CRP

  baseline, 6 month

• Change in Myostatin

  baseline, 6 month

• Change in Activing A

  baseline, 6 month

Study Arms (2)

Multidomain intervention group

EXPERIMENTAL

The multidomain intervention program is designed as structural training sessions of 2-hour training sessions two times per week.

Behavioral: Multi-domain intervention

Usual care group

NO INTERVENTION

Provide conventional health educations in every three-month interval

Interventions

Multi-domain intervention BEHAVIORAL

Each session comprises of 45 minutes physical fitness activities targeting on muscle strength, balance, and flexibility; 1-hour cognitive training primarily on reasoning and memory exercises; and 15-minute for nutritional advices based on national diet guidelines for older adults

Multidomain intervention group

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• aged ≥ 65 years
• slow gait speed (\<1 m/s in 6-meter walk test) or weakness (dominant handgrip strength \<28 kg in men, \<18 kg in women)

You may not qualify if:

• established diagnosis of dementia, Parkinsonism or other mobility-limiting, disable conditions
• active, acute diseases receiving treatment, such as cancer, heart failure, COPD and so on
• estimated life expectancy \<12 months
• current nursing home residents

Sponsors & Collaborators

• National Yang Ming Chiao Tung University: lead
• National Health Research Institutes, Taiwan: collaborator

Study Sites (1)

Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University

Taipei, 112, Taiwan

RECRUITING

Study Officials

• Li-Ning Peng, M.D., PhD

  Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Li-Ning Peng, M.D., PhD

CONTACT

+886-28239014; lining.peng@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 25, 2024
• First Posted: October 28, 2024
• Study Start: April 1, 2024
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: October 28, 2024

Record last verified: 2024-10

Locations

TW (1)