Domain-general and Domain-specific Contributions to the Development of Numerical Cognition

NCT06658392 | Completed

• 1 other identifier: D20-P011
• Study Type: interventional
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

Exploring the non-symbolic and symbolic arithmetic competencies in two groups of children (5-, and 7-year-olds). Additionally, we explored the relationship with domain-general factors such as inhibition and attention. Recorded fMRI.

Conditions

No Condition

Keywords

cognitive neuroscience; numerical cognition

Outcome Measures

Primary Outcomes (2)

• BOLD response

  changes of BOLD response under different experimental conditions (non-symbolic arithmetic; symbolic arithmetic; inhibition; attention)

  BOLD response recorded during fMRI session

• BOLD response

  changes of BOLD response in experimental conditions

  during fMRI session

Study Arms (1)

arithmetic

EXPERIMENTAL

exploring neurocognitive mechanisms underlying development of arithmetic competencies in healthy children.

Other: cognitive tasks

Interventions

cognitive tasks OTHER

no intervention in a medical sense, only observing changes of BOLD signal during different experimental conditions in cognitive tasks (arithmetic, attention, inhibition)

arithmetic

Eligibility Criteria

• Age: 5 Years - 7 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• school enrollment
• French as mother tongue
• right-handed
• normal medical, neurological and neuroradiological examinations - parents affiliated to a social security scheme

You may not qualify if:

• not within age range
• monocygotic twins
• \- contraindications to an MRI examination (neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic ocular or cerebral foreign bodies close to nerve structures, metal prostheses, patient agitation: uncooperative or agitated patients, claustrophobic subjects, ventriculoperitoneal neurosurgical shunt valves, dental apparatus, etc.).
• sudden onset of cognitive problems that could indicate a stroke; a history of head trauma with loss of consciousness lasting more than 1 hour, or encephalitis; - a chronic neurological, psychiatric, endocrine, hepatic or infectious condition
• a history of major illness (diabetes, chronic lung disease, severe cardiac, metabolic, hematological, endocrinological or immunological disorders, cancer); - medication likely to interfere with brain imaging measurements
• color blindness or uncorrected visual disorders
• inability to take part in the study for geographical or psychiatric reasons
• presence of pervasive developmental and/or acquisition disorders identified by parents or legal guardians and/or teachers
• cerebral palsy
• impaired fine motor skills
• parents or legal guardians not affiliated to a social security scheme
• unaccompanied by parent(s) or legal guardian(s) during visits.
• tattoo not compatible with MRI
• children and parents under legal protection

Sponsors & Collaborators

• Centre Hospitalier St Anne: lead

Study Sites (1)

Centre Hospitalier Sainte-Anne

Paris, 75014, France

Location

Study Officials

• Catherine OPPENHEIM, Pr

  Promotor

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 3, 2024
• First Posted: October 26, 2024
• Study Start: March 30, 2021
• Primary Completion: September 27, 2024
• Study Completion: September 27, 2024
• Last Updated: October 26, 2024

Record last verified: 2024-09

Locations

FR (1)