The Impact of Inflammatory Adhesion on the Prognosis of Colon Cancer Patients

NCT06655285 | Completed

• 1 other identifier: NCC3650
• Study Type: observational
• Target: 229
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to explore the impact of tumor-associated inflammatory adhesion on the prognosis of colon cancer patients.

Conditions

Colon Cancer

Keywords

Colon Cancer; Prognosis; Tumor-associated inflammatory adhesion

Outcome Measures

Primary Outcomes (3)

• Overall survival time (OS)

  OS, defined as the time from the first diagnosis to death from any cause or the last follow-up for surviving patients

  up to 10 years

• Cancer-specific survival time (CSS)

  CSS refers to the duration from diagnosis of a tumor until the patient succumbs to the tumor, excluding deaths from other causes.

  up to 10 years

• Recurrence free survival time (RFS)

  RFS is the time from the time a patient achieved R0 resection after surgery to the time of recurrence or the end of follow-up.

  up to 10 years

Study Arms (2)

the U.S. National Cancer Center SEER database

SEER\*Stat software (version 8.4.3) collected 17 registries cohort data on colon cancer patients between 2010 and 2019.

Other: This was a retrospective study and no patient intervention was performed.

Chinese multi-center database

Chinese multi-center database includes patients from January 2010 to December 2021 at 3 institutions.

Other: This was a retrospective study and no patient intervention was performed.

Interventions

This was a retrospective study and no patient intervention was performed. OTHER

This was a retrospective study and no patient intervention was performed.

Chinese multi-center database; the U.S. National Cancer Center SEER database

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study utilized the Chinese multi-center database as well as the SEER 17 registries database. The Chinese multi-center database contains data of patients between January 2010 and December 2021, at 3 institutions. SEER\*Stat software (version 8.4.1.1) was used for collecting 17 registries cohort data on patients diagnosed with NMIBC between 2010 and 2019.

You may qualify if:

• The patient was pathologically diagnosed as colon adenocarcinoma by endoscopic biopsy before operation.
• All patients were considered to have tumors invading adjacent organs during surgery
• All patients underwent radical surgery.

You may not qualify if:

• \. Patients with distant metastasis, recurrent colon cancer and pT4b CRC were excluded.

Sponsors & Collaborators

• Cancer Institute and Hospital, Chinese Academy of Medical Sciences: lead

Study Sites (1)

Cancer Hospital Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, 100021, China

Location

MeSH Terms

Conditions

Colonic Neoplasms

Condition Hierarchy (Ancestors)

Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Study Record Dates

• First Submitted: October 22, 2024
• First Posted: October 23, 2024
• Study Start: October 24, 2024
• Primary Completion: October 26, 2024
• Study Completion: October 27, 2024
• Last Updated: November 7, 2024

Record last verified: 2024-11

Locations

CN (1)