Mood Disorders in Multiple Sclerosis Patients

NCT06652308 | Completed

• 1 other identifier: MSMood2024-SDU
• Study Type: observational
• Target: 85
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the frequency of unipolar and bipolar mood disorders in patients with multiple sclerosis. MS is a chronic condition that affects the central nervous system, and previous research suggests that mood disorders, such as depression and bipolar disorder, may occur more frequently in MS patients compared to the general population. A retrospective analysis of 85 patients diagnosed with MS was conducted, evaluating lifetime experiences with mood disorders using structured clinical interviews. The goal is to better understand the prevalence of these mood disorders and to raise awareness of the importance of mental health care in patients with MS. The findings highlight that mood disorders, particularly bipolar disorder, are more common in MS patients than previously thought. This information can help healthcare providers improve screening, diagnosis, and treatment for MS patients suffering from mood disorders.

Conditions

Multiple Sclerosis (MS); Unipolar Depression; Bipolar Disorder; Mood Disorders

Keywords

Multiple Sclerosis; Mood Disorders; Unipolar Depression; Mental Health

Outcome Measures

Primary Outcomes (1)

• 6-year Frequency of Mood Disorders

  The primary outcome measure is the 6-year frequency of mood disorders (unipolar and bipolar) diagnosed in patients with multiple sclerosis (MS). This will be evaluated using semi-structured clinical interviews based on DSM-IV criteria.

  6-year assessment (from diagnosis of MS).

Study Arms (1)

Multiple Sclerosis Patients with Mood Disorders

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study population consists of 85 patients diagnosed with multiple sclerosis who were selected through simple random sampling from the Iranian MS Association. The cohort includes: Gender Distribution: 45 females (52.9%) 40 males (47.1%) Age Range: Participants are aged between 18 and 65 years. The average age of participants is approximately 5.47 years (please verify if this is correct as it seems like it might be a typo). Geographic Location: All participants reside in Tehran, Iran.

You may qualify if:

• Diagnosis of Multiple Sclerosis: Participants must have a confirmed diagnosis of multiple sclerosis (MS) by a qualified neurologist.
• Age Range: Participants must be between 18 and 65 years of age.
• Informed Consent: Participants must provide informed consent to participate in the study.
• Geographic Location: Participants must reside in Tehran, Iran.

You may not qualify if:

• Other Neurological Disorders: Individuals with a diagnosis of any other neurological disease (e.g., epilepsy, Parkinson's disease) will be excluded.
• Head Trauma: History of head trauma that resulted in impaired consciousness or memory loss.
• Seizures: A history of seizures that could affect mood.
• Substance Dependence: A history of substance dependence as per DSM-IV criteria.
• Other Physical Illnesses: Any systemic or physical diseases that could lead to mood symptoms.

Sponsors & Collaborators

• Islamic Azad University, Sanandaj: lead

Study Sites (1)

Shandong University

Jinan, China

Location

MeSH Terms

Conditions

Multiple Sclerosis; Depressive Disorder; Bipolar Disorder; Mood Disorders; Psychological Well-Being

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Mental Disorders; Bipolar and Related Disorders; Personal Satisfaction; Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: October 16, 2024
• First Posted: October 22, 2024
• Study Start: July 1, 2024
• Primary Completion: August 30, 2024
• Study Completion: September 30, 2024
• Last Updated: October 22, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)