Aerobic Exercise Effects on Cognitive Function in Aging Individuals

NCT06650345 | Completed

• 1 other identifier: RRC-2013-015
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

Positive effects are exerted by participating in moderate exercise training with physical activity which positively affects body health, including cognitive abilities, among older adults. Thus, the investigators are trying to study the potential effects of the supervised aerobic training regimen for 12 weeks on cognitive function among older adults based on molecular changes in cellular apoptosis.

Conditions

Cognitive Function; Exercise Training

Keywords

Cognitive abilities ,Apoptosis, LOTCA,exercise

Outcome Measures

Primary Outcomes (3)

• Assessment of body weight as anthropometric measurements

  the impact of exercise training program on body weight was identified pre and post exercise period. Weight measurements in kilograms from all participants were estimated by employing a standardized approach, utilizing a tape measure and a calibrated Salter Electronic Scale (Digital Pearson Scale; ADAM Equipment Inc., Columbia, MD, USA). The calculated weights were used to estimate BMI of each recpective participant.

  3 month

• Assessment of body height as anthropometric measurements

  the impact of exercise training program on body height was identified pre and post exercise period. A standardized approach, utilizing a tape measure and a calibrated Salter Electronic Scale (Digital Pearson Scale; ADAM Equipment Inc., Columbia, MD, USA) were used to estimate body height of each participants. The values of body height in meters were used in combination with body weight to perform BMI of its respective participant.

  3 month

• Assessment of BMI as as anthropometric measurements

  Assessment of body mass index ( BMI in kg/m\^2)as anthropometric measurements In this test, BMI from body weight and height measurements for each participant were estimated before and after exercise training interventions by using a bioelectrical impedance analysis (BIA) based body composition analyzer (TBF 105, Tanita Corporation, Tokyo, Japan)

  3 month

Secondary Outcomes (4)

• Assessment of cognitive abilities

  3 month

• Assessment of serum Bcl-2 as apoptotic-related protein

  3 month

• Assessment of serum cytochrome c as apoptotic-related protein

  3 month

• Assessment of serum p53 (pg/ml) as apoptotic-related protein

  3 month

Study Arms (2)

the control group

NO INTERVENTION

non-exercised participants with daily life activities

exercise group

EXPERIMENTAL

participants engaged in a 12-week exercise regimen structured thrice weekly.Each session's intensity was customized to match the individual's maximum and resting heart rates. The warm-up involved stretching and a 5 to 10-minute walk. In the core exercise phase, participants aimed to reach their predetermined training heart rate (THR max; between 60 to 70%) for 45-60 minutes through intervals on a treadmill, bike, or stair climber.The exercise protocol was designed to elicit physical exertion equivalent to 30-45% of their maximum oxygen consumption (VO2 max)

Other: supervised aerobic exercise

Interventions

supervised aerobic exercise OTHER

In this training program, the participants exercised for 45-60 minutes through intervals on a treadmill, bike, or stair climber, three times a week for 12 weeks.

exercise group

Eligibility Criteria

• Age: 65 Years - 95 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• home resident older
• healthy individuals
• the participants were aged between 65 and 95

You may not qualify if:

• Participants with Any physical impairments or conditions such as endocrine, immune, or psychiatric disorders
• participants with eating disorders
• participants' use of any glucocorticoid medications, which might impact the assessment of apoptotic and cognitive functions.

Sponsors & Collaborators

• King Saud University: lead

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical investigator

Model Details: The participants were categorized into two groups, specifically the control group (consisting of 30 individuals) and the exercise group (also comprising 30 individuals), based on their participation in an exercise program.

Study Record Dates

• First Submitted: October 7, 2024
• First Posted: October 21, 2024
• Study Start: December 25, 2013
• Primary Completion: November 30, 2014
• Study Completion: December 30, 2014
• Last Updated: October 21, 2024

Record last verified: 2024-10