Association of Inflammatory Markers With Preoperative Anxiety and Agitation

NCT06648122 | Completed

• 1 other identifier: 09/2024;5
• Study Type: observational
• Target: 350
• Locations: 1 country
• Sites: 1

Brief Summary

This study was planned as a prospective, observational study. The study will include pediatric patients aged 3-12 who will undergo surgery. Our hypothesis is that haemogram parameters, which are a simple, cheap and accessible method, and the inflammatory markers we obtain from them are associated with preoperative anxiety and emergence delirium

Conditions

Preoperative Anxiety; Emergence Agitation

Keywords

Children; Preoperative anxiety; Emergence agitation; Inflammation

Outcome Measures

Primary Outcomes (1)

• PAED score

  Emergence agitation will be evaluated in the postoperative unit with PAED scoring. PAED (Paediatric Emergence Delirium) parameters includes child makes eye contact with caregiver, child's actions are purposeful, child is aware of his/her surroundings, child is restless, child is inconsolable.All items are scored on a 0-4 point scale as occurring not at all, just a little, quite a bit, very much, If the sum of the five-parameter scale scores is ≥ 10, emergence agitation can be mentioned.

  first 30 minutes in the postoperative unit.

Secondary Outcomes (2)

• mYPAS score

  15 minutes before surgery in the preoperative unit

• Demographic data

  until the completion of surgery

Interventions

laboratory results OTHER

evaluation of laboratory results (hemogram results:WBC, RBC, Hematocrit, Monocyte count, Neutrophil count, Lymphocyte count, Platelet count, PDW, MPV, MLR, NLR, NMR, PLR, PMR, PNR, PWR, SII)

Eligibility Criteria

• Age: 5 Years - 12 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Children who will undergo surgery

You may qualify if:

• Pediatric patients aged 5-12 years
• ASA I-II groups
• Pediatric patients who will undergo surgery in ophthalmology, urological surgery, ENT surgery, pediatric surgery, orthopedic and plastic surgery.

You may not qualify if:

• Those with genetic disorders affecting brain development
• Those diagnosed with psychiatric and neurological diseases
• Patients with attention deficit, mental retardation
• Patients with hematological and/or immune system disorders
• Patients who will undergo surgery in neurosurgery and cardiovascular surgery.

Sponsors & Collaborators

• Cukurova University: lead

Study Sites (1)

Cukurova University, Faculty of Medicine, Department of Anesthesiology

Adana, Turkey, 01380, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Emergence Delirium; Inflammation

Condition Hierarchy (Ancestors)

Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: October 8, 2024
• First Posted: October 18, 2024
• Study Start: October 21, 2024
• Primary Completion: July 30, 2025
• Study Completion: July 30, 2025
• Last Updated: August 1, 2025

Record last verified: 2025-07

Locations

TU (1)