Retrospective Analysis of Clinical and CT Features to Predict Spread Through Air Space in Stage IA Lung Adenocarcinoma

NCT06645743 | Not Yet Recruiting DMC

• 1 other identifier: KYLX2023-137
• Study Type: observational
• Target: 1,100
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to provide a basis for the selection of surgical methods for patients with stage IA lung adenocarcinoma. Air cavity dissemination is a poor prognostic factor for patients with stage IA lung adenocarcinoma. We retrospectively collected clinical and imaging data of stage IA lung adenocarcinoma patients. Independent risk factors associated with spread through air space in stage IA lung adenocarcinoma patients were analyzed, so as to predict the occurrence of spread through air space and provide basis for the selection of surgical methods

Conditions

Tomography, X-Ray Computed; Spread Through Air Space; Clinical Features; Stage IA Adenocarcinoma of Lung

Keywords

clinical feature; Radiologic characteristic; Lung adenocarcinoma; spread through air space

Outcome Measures

Primary Outcomes (1)

• Accuracy of Predicting Spread Through Air Spaces (STAS) in Stage IA Lung Adenocarcinoma Using Clinical and Imaging Features

  This outcome measure assesses the accuracy of using preoperative clinical and CT imaging features to predict the presence of spread through air spaces (STAS) in patients with stage IA lung adenocarcinoma.Measure: Area Under the ROC Curve (AUC), sensitivity, and specificity for the prediction model.

  Preoperative clinical and imaging data collected within 2 weeks prior to surgery, retrospectively analyzed from patients who underwent surgery within the past 3 years

Secondary Outcomes (1)

• Prognostic Impact of STAS on Recurrence-Free Survival

  From the date of surgery to the time of disease recurrence or last follow-up, up to 5 years.

Study Arms (2)

spread through air space positive group

The patients in this group were stage IA lung adenocarcinoma patients who met the inclusion and exclusion criteria, and the postoperative pathological results indicated the presence of spread through air space

spread through air space negative group

The patients in this group were stage IA lung adenocarcinoma patients who met the inclusion and exclusion criteria, and the postoperative pathological results showed no spread through air space

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be selected from patients diagnosed with Stage IA lung adenocarcinoma after surgery who have undergone preoperative evaluation of clinical and CT imaging at the Third Affiliated Hospital of Kunming Medical University within the past five years

You may qualify if:

• Preoperative CT images reported that the maximum diameter of pulmonary nodules was less than 3 cm
• All subjects provided CT imaging obtained from Yunnan Cancer Hospital within a 2-week period prior to surgery
• Postoperative pathological diagnosis of invasive lung adenocarcinoma
• Remote metastasis was excluded by preoperative imaging (CT, PET-CT, ultrasound, etc.)
• Age ≥ 18 years

You may not qualify if:

• Incomplete collection of medical records, imaging data, or hematology data
• Preoperative complications of other malignant tumors
• Unclear correspondence between postoperative pathological report and preoperative CT nodule location
• Images do not meet analysis conditions due to pulmonary infection or large respiratory motion artifacts
• Postoperative pathology revealed two or more nodules classified as infiltrating adenocarcinoma
• Prior lung surgery or preoperative neoadjuvant therapy

Sponsors & Collaborators

• The Third Affiliated Hospital of Kunming Medical College.: lead

Study Sites (1)

The Third Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, 650000, China

Location

Related Links

• Provides global information and statistics on lung cancer
• A free search engine providing access to a vast collection of biomedical and life sciences literature, including MEDLINE-indexed articles, covering topics such as medicine, pharmacology, and healthcare research.
• The Third Affiliated Hospital of Kunming Medical University provides comprehensive cancer care, including surgery, radiotherapy, chemotherapy, and immunotherapy, along with advanced diagnostic and imaging services.

MeSH Terms

Conditions

Adenocarcinoma of Lung

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site

Study Officials

• Lianhua Ye

  The Third Affiliated Hospital of Kunming Medical University

  STUDY DIRECTOR

Central Study Contacts

Yantao Yang

CONTACT

+86 18288509115; 2443804244@qq.com

Huilian Hu

CONTACT

+86 13769123627; 1922957250@qq.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: doctor

Study Record Dates

• First Submitted: October 11, 2024
• First Posted: October 17, 2024
• Study Start: October 25, 2024
• Primary Completion: February 21, 2025
• Study Completion: February 21, 2025
• Last Updated: October 17, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)