Study of the Correlation Between Donor CIRBP and Transplanted Kidney Function

NCT06641622 | Completed

• 1 other identifier: II-2024-046-02
• Study Type: observational
• Target: 207
• Locations: 1 country
• Sites: 1

Brief Summary

Deceased donors and recipients who successfully completed kidney transplantation between 2016 and 2019 were included in this study. Donor plasma CIRBP levels were measured using an ELISA kit to evaluate their association with DGF incidence.

Conditions

Kidney Transplant; Complications; Delayed Graft Function

Keywords

kidney transplantation; cold-inducible RNA binding protein; delayed graft function

Outcome Measures

Primary Outcomes (1)

• recipients developed delayed graft function

  DGF was defined as a decrease in daily plasma creatinine of less than 10% from the previous day for 3 consecutive days within 1 week postoperatively, or if serum creatinine (SCr) did not decrease to 400 μmol/L within 1 week after surgery

  within 1 week after surgery

Study Arms (2)

delayed graft function

DGF was defined as a decrease in daily plasma creatinine of less than 10% from the previous day for 3 consecutive days within 1 week postoperatively, or if serum creatinine (SCr) did not decrease to 400 μmol/L within 1 week after surgery

Diagnostic Test: Prediction of delayed graft function

immediate graft function

Recipients who did not develop DGF were categorized as IGF

Interventions

Prediction of delayed graft function DIAGNOSTIC_TEST

Donor plasma CIRBP levels were measured using an ELISA kit to evaluate their association with DGF incidence

delayed graft function

Eligibility Criteria

• Age: 10 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Our study was a retrospective open cohort study that included deceased patients from January 2016 to December 2019. It adhered to the guidelines of the National Program for Deceased Organ Donation in China and involved successful kidney donors from the Third Affiliated Hospital of Sun Yat-sen University.

You may qualify if:

• Kidney donors who meet the criteria for donation;
• First-time kidney transplant recipients;
• Transplantation using cadaveric donor kidneys;
• Signing of the Human Organ Donation Relative Acknowledgement Registration Form.

You may not qualify if:

• those without a blood specimen;
• contamination of the blood specimen affecting the CIRBP level;
• recipients of combined multi-organ transplants;
• those participating in other clinical trials;
• the existence of a previous history of other organ transplants;
• any other condition that, in the opinion of the investigator, makes enrolment unsuitable.

Sponsors & Collaborators

• Third Affiliated Hospital, Sun Yat-Sen University: lead

Study Sites (1)

The Third Affiliated Hospital of Sun Yat-sen University

Guangzhou, Guangdong, 510000, China

Location

Related Publications (2)

• Yang R, Zhan M, Nalabothula NR, Yang Q, Indig FE, Carrier F. Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3'-untranslated region of ataxia telangiectasia mutated and Rad3-related (ATR) transcript. J Biol Chem. 2010 Mar 19;285(12):8887-93. doi: 10.1074/jbc.M109.013128. Epub 2010 Jan 26.

  PMID: 20103595 BACKGROUND

• Leng Q, Ma M, Tang Z, Jiang W, Han F, Huang Z. Assessing donor kidney function: the role of CIRBP in predicting delayed graft function post-transplant. Front Immunol. 2025 Jan 17;15:1518279. doi: 10.3389/fimmu.2024.1518279. eCollection 2024.

  PMID: 39896811 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

blood sample

MeSH Terms

Conditions

Delayed Graft Function

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Qianghua Leng

  Third Affiliated Hospital, Sun Yat-Sen University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 10, 2024
• First Posted: October 15, 2024
• Study Start: December 1, 2023
• Primary Completion: August 10, 2024
• Study Completion: October 10, 2024
• Last Updated: October 15, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR
• Time Frame: March 2025, for 3 years

Locations

CN (1)