Brain Health in Midlife
ADORE BRAIN
2 other identifiers
observational
24
1 country
1
Brief Summary
The purpose of this study is to learn if hypertensive disorders during pregnancy affects brain health in midlife.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Sep 2024
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 29, 2024
CompletedStudy Start
First participant enrolled
September 23, 2024
CompletedFirst Posted
Study publicly available on registry
October 15, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 13, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
June 13, 2025
CompletedJune 29, 2025
June 1, 2025
9 months
August 29, 2024
June 26, 2025
Conditions
Outcome Measures
Primary Outcomes (4)
Cardiometabolic markers of middle age women
Assess cardiometabolic marker values differences between the women diagnosed with a hypertensive disorder of pregnancy to the values of the healthy control.
Baseline
Neurovascular hemodynamics of middle age women
Assess differences in heart rate via an ECG, and beat to beat blood pressure, cerebral blood flow, and pulse wave velocity) between the women diagnosed with hypertensive disorder of pregnancy to the values of the healthy control.
Baseline
Brain structure & function of middle age women
Assess differences in MRI MPRAGE, fMRI and DTI sequencing scan between the women diagnosed with hypertensive disorder of pregnancy to the values of the healthy control.
Baseline
Alzheimer's disease-related plasma biomarkers of middle age women
Assess value differences in a predetermined Alzheimer's disease-related plasma biomarkers between the women diagnosed with hypertensive disorder of pregnancy to the values of the healthy controls.
Baseline
Study Arms (2)
Hypertensive disorder of pregnancy
Women who were diagnosed with a hypertensive disorder of pregnancy during the ADORE study participation.
Healthy pregnancy
Women who participated in the ADORE study and had a healthy pregnancy during their participation.
Interventions
Participants will be asked to complete a blood draw, 5-lead ECG, MRI, a series of cognitive assessments, dietary assessments, monitor sleep and physical activity and DXA scan.
Eligibility Criteria
Women who previously participated in the ADORE, received a hypertensive disorder diagnosis or had a healthy pregnancy during their participation.
You may qualify if:
- Participated in the ADORE trial ( R01 HD083292)
You may not qualify if:
- History of seizures or Epilepsy
- Pregnant at screening
- Ineligible to complete MRI due to metal in the body
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
The University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
Biospecimen
Whole blood
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Holly R Hull, PhD
University of Kansas Medical Center
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 29, 2024
First Posted
October 15, 2024
Study Start
September 23, 2024
Primary Completion
June 13, 2025
Study Completion
June 13, 2025
Last Updated
June 29, 2025
Record last verified: 2025-06