Impact of the COVID-19 Pandemic on Oncologic Outcomes in Colorectal Cancer

NCT06638957 | Completed

• 1 other identifier: COVID
• Study Type: observational
• Target: 14,951
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to assess the impact of the COVID-19 pandemic on colorectal cancer (CRC) outcomes, particularly focusing on stage distribution and recurrence-free survival in patients undergoing surgery at eight tertiary care institutions in Korea from 2018 to 2020. Main Question Does the COVID-19 pandemic lead to more advanced stages of colorectal cancer at diagnosis and higher complication rates during surgery? Is there a significant difference in recurrence-free survival between CRC patients treated before and during the pandemic? This study found that more patients presented with advanced-stage CRC during the COVID-19 pandemic, with significantly higher rates of tumor-related complications (perforations, abscesses, and preoperative obstructions), as well as an increase in open surgeries and combined resections. No significant difference in recurrence-free survival was observed between the pre-COVID-19 and COVID-19 periods, although postoperative complication rates were higher, especially among rectal cancer patients and those receiving preoperative chemoradiotherapy.

Conditions

Colorectal Carcinoma; COVID 19

Keywords

colorectal; covid; oncologic outcome

Outcome Measures

Primary Outcomes (1)

• stage distribution in patients who underwent CRC surgery during the pre-COVID-19 period, compared with those who underwent the surgery during the COVID-19 period.

  We aimed to document the pathological stage for each patient based on the biopsy results after surgery and analyze how the stage distribution differed between the pre-COVID and COVID groups.

  At the time the biopsy results were available for patients who underwent surgery between 2018 and 2020 (7 days after surgery).

Secondary Outcomes (1)

• 2-year recurrence free survival (RFS) and surgical complication rate in patients who underwent CRC surgery during the pre-COVID-19 period, compared with those who underwent the surgery during the COVID-19 period.

  Outcome measures will be assessed at 2 years post-surgery.

Study Arms (2)

patients with colorectal cancer who underwent surgical treatment from 2018 to 2020

The pre-COVID-19 period extended from 2018 to February 2020

patients with colorectal cancer who underwent surgical treatment from 2020

the COVID-19 period began in March 2020 to December 2020

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Between 2018 and 2020, 14951 patients underwent surgery for suspected CRC across the eight institutions.

You may qualify if:

• Patients diagnosed with colorectal cancer who underwent surgery
• in 8 institution including Asan Medical Center, Seoul St. Mary's Hospital, Korea University Anam Hospital, Samsung Medical Center, Pusan National University Yangsan Hospital, Gangnam Severance Hospital, Kyungpook National University Chilgok Hospital, and Chonnam National University Hwasun Hospital

You may not qualify if:

• Familial adenomatous polyposis (FAP)
• Hereditary non-polyposis colon cancer (HNPCC)
• Cancer associated with inflammatory bowel disease (IBD)
• Colorectal cancer not proven on biopsy, and pathologies other than adenocarcinoma.
• Emergency operation

Sponsors & Collaborators

• In Ja Park: lead
• Kyungpook National University Chilgok Hospital: collaborator
• Gangnam Severance Hospital: collaborator
• Chonnam National University Hospital: collaborator
• Korea University Anam Hospital: collaborator
• Pusan National University Yangsan Hospital: collaborator
• Samsung Medical Center: collaborator
• Seoul Saint Mary's Hospital: collaborator

Study Sites (1)

Asan medical center

Seoul, Songpa, 05505, South Korea

Location

MeSH Terms

Conditions

Colorectal Neoplasms; COVID-19

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 7, 2024
• First Posted: October 15, 2024
• Study Start: January 1, 2018
• Primary Completion: December 31, 2020
• Study Completion: September 20, 2024
• Last Updated: October 15, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)