NCT06631872

Brief Summary

The physiological challenge of major surgery has been likened to running a marathon. In both cases, preparation is critical. Yet, many patients undergo major surgery without understanding the potential consequences. The STTARRS trial aims to test the effect of an education program delivered via telehealth in people preparing for lung or major abdominal cancer surgery , compared with usual care on the development of a respiratory complications after surgery. The secondary aims will be to determine the effect of the online education program for people preparing for lung or major abdominal cancer surgery compared to usual care on the following outcomes; acute hospital length of stay, surgical recovery, physical function and activity, self-efficacy, behaviour change, symptoms, health-related quality of life, number of days alive and out of hospital and health service usage and survival. This trial includes one sub-study. The sub-study will recruit eligible people preparing for lung cancer surgery. In the sub-study, 35 participants will receive an individualised inspiratory muscle training and walking program delivered and monitored by telehealth in addition to the main STTARRS trial intervention before surgery.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
515

participants targeted

Target at P75+ for not_applicable

Timeline
26mo left

Started Jan 2025

Longer than P75 for not_applicable

Geographic Reach
1 country

6 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress38%
Jan 2025Jul 2028

First Submitted

Initial submission to the registry

September 15, 2024

Completed
23 days until next milestone

First Posted

Study publicly available on registry

October 8, 2024

Completed
4 months until next milestone

Study Start

First participant enrolled

January 22, 2025

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2027

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2028

Last Updated

August 27, 2025

Status Verified

October 1, 2024

Enrollment Period

2.4 years

First QC Date

September 15, 2024

Last Update Submit

August 20, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Post operative Pulmonary Complication (PPC)

    Post operative pulmonary complications (PPC) will be assessed using the Melbourne Group Score (MGS). The MGS is an eight-item checklist. Minimum score 0, Maximum score 8. Participants are identifying as having a PPC if they score four or more in a 24-hour period.

    Daily for up to 7 days post operatively or until hospital discharge.

Secondary Outcomes (32)

  • Diagnosis of pneumonia

    Daily up to postoperative day 7 or until hospital discharge

  • Postoperative complications

    Postoperative day 3,5,10 unless discharge prior and 30 days post operative.

  • Number of days alive and out of hospital

    30 days, 6 months and 12 months post operative

  • Maximal Inspiratory Pressure (MIP)

    Baseline and preoperatively at centres participating in the inspiratory muscle training sub study

  • Physical activity levels - subjective

    Baseline, Preoperatively, 30 days post operative

  • +27 more secondary outcomes

Other Outcomes (16)

  • Sex

    Baseline

  • Date of birth

    Baseline

  • Height

    Baseline

  • +13 more other outcomes

Study Arms (4)

Tele-prehabilitation intervention (Intervention Group)

EXPERIMENTAL

The Teleprehabilitaiton intervention (also known as Surgery School) is a one-off group based education session delivered online. Video presentations of 8-10 key prehabilitation education areas will be facilitated by a live clinician facilitator who will introduce the educational content and answer any questions. All standardised video presentations during the session will be made available to participants through an online password-protected video repository hosted on a video platform after the session and will be available until their surgery.

Behavioral: Tele-prehabilitation education session: Surgery School

Usual care alone (Control Group)

ACTIVE COMPARATOR

Participants allocated to the control group will receive usual care according to their health care team, which may consist of advice on smoking cessation, reduction of alcohol intake, nutritional counselling and medical optimisation in preoperative anaesthetic clinic visits. Participants will be asked to maintain their normal daily activities.

Other: Usual Care

Sub-study: Tele-prehabilitation and inspiratory muscle training program

EXPERIMENTAL

Eligible participants awaiting lung cancer surgery that have been randomised into the intervention arm will be re-randomised to receive either the STTARRS (larger trial) intervention or the STTARRS intervention PLUS an individualised inspiratory muscle training and walking program delivered by a physiotherapist using telehealth in the lead up to their lung cancer surgery. The inspiratory muscle training program includes an inspiratory muscle training explanatory video and an individually prescribed dosage and resistance for inspiratory muscle training and walking program, delivered via telehealth.

Behavioral: Tele-prehabilitation education session: Surgery SchoolBehavioral: Individualised Inspiratory Muscle Training and Walking Program

Sub-study: Tele-prehabilitation intervention

ACTIVE COMPARATOR

The Teleprehabilitaiton intervention (also known as Surgery School) is a one-off group based education session delivered online. Video presentations of 8-10 key prehabilitation education areas will be facilitated by a live clinician facilitator who will introduce the educational content and answer any questions. All standardised video presentations during the session will be made available to participants through an online password-protected video repository hosted on a video platform after the session and will be available until their surgery.

Behavioral: Tele-prehabilitation education session: Surgery School

Interventions

Online telehealth education program using videos and a live clinician facilitator

Sub-study: Tele-prehabilitation and inspiratory muscle training programSub-study: Tele-prehabilitation interventionTele-prehabilitation intervention (Intervention Group)

An individualised inspiratory muscle training and walking program delivered by a Physiotherapist using telehealth.

Sub-study: Tele-prehabilitation and inspiratory muscle training program

Usual care alone. Usual care will be reviewed every four months during the trial and site leads will be asked to provide information about any changes to usual hospital and medical care at their site.

Usual care alone (Control Group)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Preparing for lung cancer (open or video assisted) or major abdominal cancer surgery (e.g. upper GI, hepatobiliary or colorectal, open or video assisted).
  • Provide consent
  • Have primary treating surgeon approval
  • Proficient in English to understand testing, video interventions as well as outcome assessments.

You may not qualify if:

  • Concurrent, actively treated other malignancy or history of other malignancy treated within the past year.
  • Severe or unstable psychiatric, cognitive or substance abuse disorders, such that precludes informed consent or interferes with cooperation with trial requirements or current inpatients.
  • Current inpatients or incarcerated
  • Surgery date booked \<7 days from consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (6)

John Hunter Hospital

New Lambton Heights, New South Wales, 2305, Australia

RECRUITING

Princess Alexandra Hospital

Woolloongabba, Queensland, 4102, Australia

RECRUITING

Launceston General Hospital

Launceston, Tasmania, 7250, Australia

NOT YET RECRUITING

Austin Health

Heidelberg, Victoria, 3084, Australia

RECRUITING

Royal Melbourne Hospital

Melbourne, Victoria, 3050, Australia

RECRUITING

Fiona Stanley Hospital

Perth, Western Australia, 6845, Australia

RECRUITING

Study Officials

  • Linda Denehy, B AppSc (Physio), PhD

    University of Melbourne

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Linda Denehy, B AppSc (Physio), PhD

CONTACT

Jamie Waterland, B Physio(Hons), PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Model Details: This is a two-arm, multicentre, comparative, assessor-blinded, randomised, controlled, hybrid (Type 1; examining both efficacy and feasibility) superiority trial that includes one sub-study.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 15, 2024

First Posted

October 8, 2024

Study Start

January 22, 2025

Primary Completion (Estimated)

July 1, 2027

Study Completion (Estimated)

July 1, 2028

Last Updated

August 27, 2025

Record last verified: 2024-10

Data Sharing

IPD Sharing
Will not share

Locations