Diagnostic and Management of Hand Infection.

NCT06630988 | Active Not Recruiting

• 1 other identifier: 24-5342
• Study Type: observational
• Target: 1,400
• Locations: 1 country
• Sites: 1

Brief Summary

Primary or secondary (post-traumatic infections, notably related to bites, wounds, etc.) infections of the hand are very common situations, even if the epidemiology is poorly understood. For example, hand bite injuries represent 1.2 million referrals to the healthcare system per year in the United States. Their nosological framework extends from simple infections of the skin and soft tissues such as whitlows, to potentially severe deep damage such as arthritis and osteitis, or phlegmons of the tendon sheaths. The diagnostic approach is not consensual, and the contribution of additional biological parameters (inflammatory syndrome) and morphological investigations (x-rays, ultrasound, CT-scan or MRI) is not codified. Microbiology seems dominated by Staphylococcus aureus, but few studies have precisely described the microbial etiology. Consequently, probabilistic antibiotic therapy and the need to take bacteriological samples for secondary adaptation are not standardized. Likewise, surgical strategies (abstention, systematic washing or depending on evolution) remain operator dependent. We consequently aim to described diagnostic, management and related outcomes or hand infections in a specialized tertiary care center.

Conditions

Hand Infections; Including Whitlows; Tendinous Infections; Septic Arthritis

Keywords

Hand infection; Whitlows; Tendinous infections; Septic arthritis

Outcome Measures

Primary Outcomes (1)

• Percentage of treatment failure during the management of hand infections.

  Treatment failure will be defined as infection persistence or relapse, need of unplanned surgery for septic reason or infection-related death.

  between 01/01/2014 and 31/12/2023.

Study Arms (1)

Hand infection

Description of whitlows, tendinous infections and septic arthritis diagnostic, management and outcome Descriptive study, no intervention

Other: Failure rates

Interventions

Failure rates OTHER

Describe the management failure rate for hand infections, including panariasis, phlegmons and arthritis.

Hand infection

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients will be selected from the data base of the hand emergency surgery department of our tertiary care center, based on a principal or secondary diagnosis of BJI appearing alone or in combination with either sepsis or a specific surgical procedure - 1400 potential patients.

You may qualify if:

• all patient ≥ 18
• yo followed-up for a hand infection in our tertiary care center
• from 01/01/2014 to 31/12/2023, including
• whitlows
• tendinous infections
• septic arthritis

You may not qualify if:

• osteomyelitis

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

HCL - Hôpital Edouard Herriot

Lyon, 69003, France

Location

MeSH Terms

Conditions

Arthritis, Infectious

Condition Hierarchy (Ancestors)

Infections; Arthritis; Joint Diseases; Musculoskeletal Diseases

Study Officials

• Florent Valour Pr Florent Valour, Pr

  Hospices Civils de Lyon

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 26, 2024
• First Posted: October 8, 2024
• Study Start: September 1, 2024
• Primary Completion: December 31, 2024
• Study Completion: June 30, 2025
• Last Updated: October 8, 2024

Record last verified: 2024-10

Locations

FR (1)