NCT06628076|Completed
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Sponsor study identifier
observational
150
1 country
1
Study Start
October 10, 2024
Actual (reported)Primary Completion
October 10, 2024
Actual (reported)Study Completion
December 30, 2025
Actual (reported)A. baumannii is known as the most frequently isolated organism in intensive care units (ICUs), causing a variety of nosocomial infections, including pneumonia, urinary tract infections (UTIs), bacteremia as well as skin and soft tissue infections. These infections are usually associated with high mortality rates ranging between 26% among hospitalized patients and 43% among ICU patients.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 30, 2025
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 26, 2024
Actual (reported)October 4, 2024
Actual (reported)October 10, 2024
Actual (reported)October 10, 2024
Actual (reported)December 30, 2025
Actual (reported)A. baumannii antibiotic susceptibility profile
A. baumannii antibiotic susceptibility profile will be done using modified kirbybeur method
October 2024 to December 2025
Isolation and identification of A. baumannii from different clinical samples
Isolation and identification of A. baumannii from different clinical samples using MacConKey medium, oxidase test. TSI, And automated identification ViteK system
October 2024 to December 2025
A. baumannii strains which produce biofilm
Detection of A. baumannii strains which produce biofilm using tissue culture plates and Gram stain
October 2024 to December 2025
Ability of ZnO NPs to inhibit the phenomenon of biofilm formation by MDR A. baumannii strains
Assessment of ability of ZnO NPs to inhibit the phenomenon of biofilm formation by MDR A. baumannii strains using ZnO NPs to be applied by different concentrations on tissue culture plates and measure the degree of Biofilm formation using ELISA
Samples will be cultured on MacConkey agar. Morphological identifications of growth isolates by Gram staining, colony features and conventional biochemical tests. All isolates will be identified to species level using automated bacterial identification systems.
Strains confirmed as A. baumannii will be examined for their different antibiotic susceptibility by modified Kirby Bauer\'s disc diffusion method on Mueller Hinton Agar.
These entries preserve how the registry describes the intervention. Their treatment roles are shown separately from molecular identities.
Formulated product
nanoparticle zinc oxide
The registry describes a specific formulation. Its exact chemical ingredients and approval status require separate evidence.
View registry recordThis study will be carried out at Department of Medical Microbiology and Immunology, Sohag Faculty of Medicine and Sohag University Hospitals.
Sohag university, Faculty of medicine
Sohag, 534568, Egypt
Different samples (pus, urine, urinary catheter samples, wound swabs, sputum, bronchoalveolar lavage and central venous catheter samples) will be collected under strict aseptic precautions from patients admitted at different departments at Sohag university hospitals
150 participants (actual enrollment reported by the registry).
First Submitted
September 26, 2024
First Posted
October 4, 2024
Study Start
October 10, 2024
Actual (reported)OM 85 to Prevent Respiratory Infections in Older At Risk Patients
October 2024 to December 2025
The effect of ZnO NPs on the expression of some efflux pump genes and biofilm related genes in MDR A. baumannii strains
Evaluation the effect of ZnO NPs on the expression of some efflux pump genes and biofilm related genes in MDR A. baumannii strains using real time PCR(Polymerase Chain reaction)
October 2024 to December 2025
The biofilm formation activity of A. baumannii isolates will be tested using the microtitre plate technique
Detection of the effect of ZnO NPs on the biofilm producer MDR A. baumannii strains using the same method
\- Evaluation the effect of ZnO NPs on the expression of some efflux pump genes, and biofilm related genes in MDR A. baumannii isolates using Real time PCR technology.
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Primary Completion
October 10, 2024
Actual (reported)Study Completion
December 30, 2025
Actual (reported)Last Updated
August 13, 2026
Record last verified: 2026-08
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Source: ClinicalTrials.gov.
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