Predictive Value of Airway Occlusion Pressure, Maximal Inspiratory Pressure and Their Ratio for Successful Extubation in Patients With Traumatic Brain Injury

NCT06627686 | Recruiting

• 1 other identifier: MS 23_7_2023
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study will be to measure the predictive power of the respiratory muscle determinants including The maximal inspiratory pressure, and central drive determinant including Airway occlusion pressure and ratio between them in weaning outcome of traumatic brain injury patients undergoing invasive mechanical ventilation.

Conditions

Weaning Failure

Outcome Measures

Primary Outcomes (1)

• Sensetivity, specifity, predictive values, and accuracy of Maximal inspiratory pressure, Airway occlusion pressure and their ratio will be determined by ROC curve.

  One day

Study Arms (1)

Traumatic brain injury

Air way occlusion pressure and maximum inspiratory pressure

Diagnostic Test: Air way occlusion pressure

Interventions

Air way occlusion pressure DIAGNOSTIC_TEST

Predictive Value of Airway Occlusion Pressure, Maximal Inspiratory Pressure and Their Ratio for Successful Extubation in Patients with Traumatic Brain Injury

Also known as: Maximal inspiratory pressure

Traumatic brain injury

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Predictive Value of Airway Occlusion Pressure, Maximal Inspiratory Pressure and Their Ratio for Successful Extubation in Patients with Traumatic Brain Injury

Traumatic brain injury (closed type) patients who will be admitted to ICU and intubated and MV more than 24 hours will be included in this study. Age from 18 to 65 years (male or female). Fulfillment of Criteria of readiness for weaning off MV : Resolution of the cause of respiratory insufficiency and MV. Stable hemodynamic profile

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Benha University: lead
• Tanta University: collaborator

Study Sites (1)

Ali Rashad Ahmed

Tanta, Mahala, 13821, Egypt

RECRUITING

MeSH Terms

Interventions

Maximal Respiratory Pressures

Intervention Hierarchy (Ancestors)

Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Ali Rashad, MBBCH

  Benha University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ali Rashad, MBBCH

CONTACT

201018020543; draliali123456@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: October 2, 2024
• First Posted: October 4, 2024
• Study Start: September 1, 2023
• Primary Completion: September 1, 2024
• Study Completion: October 5, 2024
• Last Updated: October 4, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)