NCT06627075

Brief Summary

The goal of this clinical trial is to test the use of surface repositioning alone, without a restraint mask, during radiotherapy sessions for patients with head and neck cancer.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
8mo left

Started Dec 2024

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress67%
Dec 2024Jan 2027

First Submitted

Initial submission to the registry

September 25, 2024

Completed
9 days until next milestone

First Posted

Study publicly available on registry

October 4, 2024

Completed
2 months until next milestone

Study Start

First participant enrolled

December 12, 2024

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 12, 2026

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 12, 2027

Last Updated

February 13, 2025

Status Verified

September 1, 2024

Enrollment Period

1.8 years

First QC Date

September 25, 2024

Last Update Submit

February 11, 2025

Conditions

Keywords

RadiotherapyOptical surface guidance

Outcome Measures

Primary Outcomes (1)

  • Measurement patient displacement during surface-guided radiotherapy sessions

    Average length of linear translation vector during session (measured by surface cameras) over all sessions performed

    Through study completion, an average of 1 year

Study Arms (1)

Surface Guided RadioTherapy without face mask

EXPERIMENTAL

Radiotherapy sessions will be carried out using the surface camera system, replacing the restraint mask. Self-assessment questionnaires will also be completed by healthcare professionals concerning the level of difficulty encountered during each SGRT session without mask. Skin side effects are recorded by the radiotherapist during weekly follow-up consultations. At the end of treatment, patients complete a patient experience questionnaire.

Procedure: Surface Guided RadioTherapy (SGRT) without mask

Interventions

Firstly, patients are positioned in a vacuum mattress that moulds their head, neck and shoulders for a reference scan. During the treatment sessions, patients are positioned according to the reference scan, using the surface camera system. Once the observed offsets have been applied, the patient's surface is captured. Treatment can then begin, with continuous monitoring of displacements by the surface camera system. Automatic beam interruption is provided during treatment in the event of motion detection exceeding the standard tolerance threshold (\>3 mm). If the use of a thermoformed mask during your treatment prove necessary, for whatever reason, will not result in a halt to the research. Patients receive between 10 and a max of 35 radiotherapy sessions. The follow-up period begins after the last radiotherapy session, and patients are assessed at 4 or 6 weeks and at 3 months by a radiotherapist.

Surface Guided RadioTherapy without face mask

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients over 18 years of age
  • Patients undergoing palliative or curative treatment for oro-rhino-laryngeal cancer
  • Patients with an indication for radiotherapy treatment, with or without complementary treatment (chemotherapy, immunotherapy), with a number of sessions between 10 and 35
  • Patients who have dated and signed an informed consent form

You may not qualify if:

  • Patients with uncontrollable movements
  • Patients under psychiatric care
  • Patients who do not understand or read French
  • Patients participating in an interventional study testing another medical intervention
  • Patients under guardianship, curatorship, safeguard of justice or deprived of liberty
  • Pregnant or breast-feeding women
  • Patients without social security coverage

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Centre de Lutte contre le Cancer Eugène Marquis

Rennes, Brittany Region, 35042, France

RECRUITING

MeSH Terms

Conditions

Otorhinolaryngologic Neoplasms

Condition Hierarchy (Ancestors)

Head and Neck NeoplasmsNeoplasms by SiteNeoplasmsOtorhinolaryngologic Diseases

Study Officials

  • Coralie Geffroy

    Centre de Lutte contre le Cancer Eugène Marquis

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 25, 2024

First Posted

October 4, 2024

Study Start

December 12, 2024

Primary Completion (Estimated)

October 12, 2026

Study Completion (Estimated)

January 12, 2027

Last Updated

February 13, 2025

Record last verified: 2024-09

Locations