A Modified-simple Technique for Managing Moderate and Severe Subluxated Lens Extraction

NCT06627062 | Completed DMC

• 1 other identifier: 202119
• Study Type: observational
• Target: 9
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators describe a modified knotless Z-suture technique to stabilize the capsular bag to the sclera in eyes with moderate and severe ectopic lentis requiring cataract surgery using a standard CTR. This technology has the advantages of few complications, low technical difficulty, and no dependence on complex equipment.

Conditions

Lens Subluxation

Keywords

Subluxated lens; Capsular bag; capsular tension ring; phacoemulsification

Outcome Measures

Primary Outcomes (1)

• Success rate of intraocular lens implantation in patients with moderate to severe subluxation of the crystalline lens

  From enrollment to the end of treatment at 1 year.

Study Arms (1)

subluxated lens extraction

This research cohort consists of patients with moderate to severe subluxation who have successfully undergone lens extraction using an improved scleral fixation standard tension ring technique.

Procedure: moderate and severe subluxated lens extraction

Interventions

moderate and severe subluxated lens extraction PROCEDURE

A double-strand polypropylene suture (9-0 or 8-0) was looped and tied to one end of the preloaded CTR, which was then implanted into the capsular bag. The needle was inserted through the main incision, traversed the anterior chamber, under the posterior iris, and exited 2.0 mm behind the limbus at the central zonular weakness. The CTR was secured to the sclera using the knotless Z-suture technique to center the capsular bag, allowing safe insertion of the intraocular lens (IOL).

Also known as: Intrascleral Fixation of Standard Capsular Tension Ring

subluxated lens extraction

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The technique was successfully used in 16 eyes of 9 patients (including 3 females and 6males) with 15 congenital and 1 traumatic lens subluxations with subluxation ranges between 120-300 degrees.

You may qualify if:

• \- Patients with moderate to severe lens subluxation ranging from 120-300 degrees caused by different reasons.

You may not qualify if:

• \- Unable to cooperate in completing the lens subluxation surgery Lens subluxation accompanied by eyeball rupture injury Refuse surgery

Sponsors & Collaborators

• Eye & ENT Hospital of Fudan University: lead

Study Sites (1)

Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University

Shanghai, Shanghai Municipality, 200031, China

Location

Related Publications (1)

• Ning L, Hong Y, Ji Y. Intrascleral fixation of standard capsular tension ring: a modified-simple technique for managing moderate and severe subluxated lens extraction. Ther Adv Ophthalmol. 2026 Jan 27;18:25158414251407874. doi: 10.1177/25158414251407874. eCollection 2026 Jan-Dec.

  PMID: 41613822 DERIVED

MeSH Terms

Conditions

Lens Subluxation

Condition Hierarchy (Ancestors)

Lens Diseases; Eye Diseases

Study Officials

• Yinghong Ji, Phd; MD

  Eye & ENT Hospital, Fudan University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 22, 2024
• First Posted: October 4, 2024
• Study Start: January 1, 2023
• Primary Completion: June 1, 2023
• Study Completion: February 28, 2024
• Last Updated: October 4, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)