A Retrospective Cohort Study on Predicting Delayed Graft Function in Liver Transplant Patients with Hepatocellular Carcinoma: a Nomogram and Machine Learning Approaches.

NCT06626724 | Completed

• 1 other identifier: Zhongnan Hospital
• Study Type: observational
• Target: 131
• Locations: 1 country
• Sites: 1

Brief Summary

Background: This study aimed to develop a predictive model for delayed graft function (DGF) in liver transplant patients with hepatocellular carcinoma (HCC) based on preoperative biochemical indicators, using both logistic regression and XGBoost machine learning algorithms. Methods: A retrospective cohort study was conducted, including 131 liver transplant patients from January 2020 to April 2022. Preoperative biochemical markers and hematological parameters were analyzed. Logistic regression and XGBoost models were constructed to predict DGF, and their performance was evaluated using the area under the ROC curve (AUC). Shapley Additive Explanations (SHAP) analysis was employed to interpret the feature contributions.

Conditions

Hepatocellular Carcinoma (HCC); DGF

Outcome Measures

Primary Outcomes (1)

• TBIL/AST/ALT/INR

  Results of biochemical examination on the 7th day after liver transplantation in patients with hepatocellular carcinoma.

Interventions

Liver transplantation PROCEDURE

Liver transplantation for patients with hepatocellular carcinoma.

Eligibility Criteria

• Age: 18 Days - 75 Days
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Patients receiving a liver transplant between January 2020 and April 2024.

You may qualify if:

• Patients with liver cancer aged between 18 and 75 years.
• Patients who have received liver transplantation.
• Complete preoperative and postoperative medical imaging data, clinical records and pathological test reports are available.

You may not qualify if:

• Primary non-hepatocellular carcinoma
• Recipients were younger than 18 years and older than 75 years
• Serious complications associated with liver transplantation, such as acute transplant rejection or transplant liver failure, occur within 7 days after surgery.
• Re-surgery within 7 days after surgery due to liver transplant-related complications or other surgical procedures, such as transplant site infection or other major surgery.

Sponsors & Collaborators

• Jian You: lead

Study Sites (1)

Zhongnan Hospital of Wuhan University

Wuhan, Hubei, 430071, China

Location

MeSH Terms

Conditions

Carcinoma, Hepatocellular

Interventions

Liver Transplantation

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Liver Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Liver Diseases

Intervention Hierarchy (Ancestors)

Tissue Transplantation; Cell- and Tissue-Based Therapy; Biological Therapy; Therapeutics; Digestive System Surgical Procedures; Surgical Procedures, Operative; Organ Transplantation; Transplantation

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Research assistant

Study Record Dates

• First Submitted: October 1, 2024
• First Posted: October 4, 2024
• Study Start: January 1, 2020
• Primary Completion: April 30, 2024
• Study Completion: April 30, 2024
• Last Updated: October 4, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)