NCT06624982

Brief Summary

The main purpose of the study is to measure and localize immediate post extraction changes i.e. socket expansion versus no width change along the socket wall and identify whether the immediate post-extraction ridge width condition (expansion or no change) is a determinant of buccolingual ridge width and height changes 4 months following extraction and ridge preservation.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
160

participants targeted

Target at P50-P75 for all trials

Timeline
17mo left

Started Oct 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress29%
Oct 2025Oct 2027

First Submitted

Initial submission to the registry

October 1, 2024

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 3, 2024

Completed
1 year until next milestone

Study Start

First participant enrolled

October 8, 2025

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2027

Last Updated

November 17, 2025

Status Verified

November 1, 2025

Enrollment Period

2 years

First QC Date

October 1, 2024

Last Update Submit

November 13, 2025

Conditions

Alveolar Bone GraftingBone HealingTooth Extraction Site HealingWound Healing

Outcome Measures

Primary Outcomes (2)

  • Buccolingual ridge width

    Buccolingual ridge width will be measured through a stent via ridge mapping calipers. The measurement locations will be at 1mm, 3mm and 5mm from the midbuccal crest. The same measurements will be recorded at all selected time points.

    (1) After local anesthesia and before extraction, (2) immediately after extraction and (3) 4 months after extraction and alveolar ridge preservation

  • Ridge height

    Ridge height will be measured through a stent via a periodontal probe as the distance between bone and predetermined landmarks on the stent. The measurement locations will be mesial buccal, midbuccal, distal buccal, mesial lingual, midlingual and distal lingual. The same measurements will be recorded at all selected time points.

    (1) After local anesthesia and before extraction, (2) immediately after extraction and (3) 4 months after extraction and alveolar ridge preservation

Study Arms (4)

Non-molar sites with immediate post-extraction ridge expansion

Non-molar sites with an increase of buccolingual bone width immediately after tooth extraction compared to pre-extraction.

Other: observational study

Non-molar sites with no immediate post-extraction ridge width change

Non-molar sites without a change in buccolingual bone width immediately after tooth extraction compared to pre-extraction.

Other: observational study

Molar sites with immediate post-extraction ridge expansion

Molar sites with an increase of buccolingual bone width immediately after tooth extraction compared to pre-extraction.

Other: observational study

Molar sites with no immediate post-extraction ridge width change

Molar sites without a change in buccolingual bone width immediately after tooth extraction compared to pre-extraction.

Other: observational study

Interventions

observational studyOTHER

Observational study; alveolar ridge preservation

Molar sites with immediate post-extraction ridge expansionMolar sites with no immediate post-extraction ridge width changeNon-molar sites with immediate post-extraction ridge expansionNon-molar sites with no immediate post-extraction ridge width change

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients scheduled for tooth extraction and alveolar ridge preservation (bone graft and membrane) in the Graduate Periodontics Clinic at Marquette University School of Dentistry.

You may qualify if:

  • Adult patients (18-75 years)
  • Good general health (controlled conditions)
  • Controlled periodontal disease
  • Scheduled for single tooth extraction with bone graft placement and resorbable membrane
  • Tooth to be extracted must have adjacent teeth
  • Socket wall integrity

You may not qualify if:

  • Smoking
  • Pregnancy
  • Active periodontal disease
  • Systemic conditions that affect healing
  • Lack of socket wall integrity (bone loss ≥50 %) prior to extraction, teeth with severe infection requiring pre-extraction antibiotic treatment to control infection), and contraindications for tooth extraction.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Marquette University School of Dentistry Graduate Periodontics Clinic

Milwaukee, Wisconsin, 53233, United States

RECRUITING

MeSH Terms

Interventions

Observation

Intervention Hierarchy (Ancestors)

MethodsInvestigative Techniques

Study Officials

  • Vrisiis Kofina, DDS, MS

    Marquette University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Vrisiis Kofina, DDS, MS

CONTACT

4142886521vrisiis.kofina@marquette.edu

Samah Rady, DDS

CONTACT

9497962173samahsy.rady@marquette.edu

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Director, Advanced Education in Periodontics Program, Assistant Professor of Periodontics

Study Record Dates

First Submitted

October 1, 2024

First Posted

October 3, 2024

Study Start

October 8, 2025

Primary Completion (Estimated)

October 1, 2027

Study Completion (Estimated)

October 1, 2027

Last Updated

November 17, 2025

Record last verified: 2025-11

Data Sharing

IPD Sharing
Will not share

Locations

US(1)