Effect of Seashell Nanoparticles and Gluma Desensitizer on Sensitivity of Teeth

NCT06622018 | Completed DMC

• 1 other identifier: Hoda El Gendy
• Study Type: interventional
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

Tooth hypersensitivity is characterized by a transient short and sharp pain originating from exposed dentin in response to thermal, dehydrating, tactile, osmotic, and chemical stimuli. Tooth sensitivity after cementation of complete coverage crowns, is a rather common event since much of the protecting enamel is removed during preparation and a large area of dentin is exposed. Dentin contains up to two million tubules per cm2, which corresponds approximately to the surface area of most crown preparations. It is well known that such dentin wounds respond to mechanical, osmotic, or thermal stimulation with pain. This phenomenon is commonly example by the hydrodynamic theory of Brannstrom.

Conditions

Teeth Sensitivity; Treated Dentin Surfaces

Outcome Measures

Primary Outcomes (1)

• Desnsetizing agent Hypersensitivity

  Evaluation of the treated patients from hypersensitivity of the application of desnsetizing agent ( gluma and nanasaesheall) by using VAS score (from 0 to 10) as 0 is mean no sensitivity while 10 is the worst.

  from 0 hours to two weeks

Secondary Outcomes (1)

• Dentinal tubule occlusion

  from 0 hours to two weeks

Study Arms (3)

Group A (Control Group)

PLACEBO COMPARATOR

About 11 patients with hypersensitive teeth of no treatment materials used

Procedure: Seashell Nanoparticles and Gluma Desensitizer

Group B(Seashell Nanoparticles Group)

ACTIVE COMPARATOR

About 11 patients with hypersensitive teeth faced treatment by sea shell nanoparticles

Procedure: Seashell Nanoparticles and Gluma Desensitizer

Group C (Gluma Group)

ACTIVE COMPARATOR

About 11 patients with hypersensitive teeth faced treatment by Gluma

Procedure: Seashell Nanoparticles and Gluma Desensitizer

Interventions

Seashell Nanoparticles and Gluma Desensitizer PROCEDURE

Evaluation the effect of Seashell Nano Particles and Gluma desensitizer on sensitivity of the teeth for Intra coronal restoration at different times

Also known as: Micromorphology

Group A (Control Group); Group B(Seashell Nanoparticles Group); Group C (Gluma Group)

Eligibility Criteria

• Age: 25 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• For patient Age between 25 and 40 years and no gender reference.
• For the teeth Absence of pulpal exposure, RCT treatments, fracture and free of extensive caries (The amount of caries that can be removed during the preparation is acceptable

You may not qualify if:

• For patients Use of desensitizing substances or drug like antihistamines, antidepressant 6 weeks before or during the study.
• Requiring antibiotic prophylaxes or cortico-steriod therapy.
• For teeth Tooth hypersensitivity prior to tooth preparation (like, abrasion or attration).

Sponsors & Collaborators

• Faculty of Dental Medicine for Girls: lead
• Al-Azhar University: collaborator

Study Sites (1)

Al-Azhar University hospitals

Cairo, Egypt

Location

MeSH Terms

Conditions

Dentin Sensitivity

Interventions

gluma desensitizer

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases

Study Officials

• Osama Saleh Abd El Ghani, Professor

  Al-Azhar Faculty of Dental Medicine for girls

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist of Dental Medicine

Study Record Dates

• First Submitted: September 28, 2024
• First Posted: October 1, 2024
• Study Start: January 10, 2023
• Primary Completion: October 5, 2023
• Study Completion: October 10, 2023
• Last Updated: October 1, 2024

Record last verified: 2023-01

Locations

EG (1)