Ali Pay Intelligent Navigation Applet-aided Pre-hospital Triage for Non-emergency Medical Service Patients With Acute Ischemic Stroke

NCT06613074 | Recruiting DMC

• 1 other identifier: i-Path
• Study Type: interventional
• Target: 20,000
• Locations: 1 country
• Sites: 1

Brief Summary

According to the Bigdata Observatory platform for Stroke of China (BOSC), the proportion of patients with acute ischemic stroke (AIS) receiving intravenous thrombolysis or endovascular treatment in China is 5.64% and 1.45% respectively. One of the important reasons for the low treatment rate is the prolonged pre-hospital and in-hospital delay. Besides, for patients receiving reperfusion therapy, the prolonged pre-treatment delay is associated with unfavorable functional outcomes. Although tons of efforts have been made to improve the efficiency of emergency medical system in the transportation of patients with AIS, little attention has been paid to patients who arrived at hospitals on their owns, which occupying approximately 2/3 of emergency patients. This leaves a huge gap in the pre-hospital management of patietns with AIS. Therefore, the investigators plan to develop an intelligent navigation system for patients with AIS. For the convenience of public use, this system was carried on the applet of Ali Pay, which has over 1.1 billion users in China. This system comprises of three functional modules, namely stroke knowledge education, stroke recognition and hospital recommendation. The investigators aim to explore whether this intelligent navigatino system could shorten pre-hospital delay and improve functional outcomes of patients with AIS undergoing reperfusion therapy.

Conditions

Acute Ischemic Stroke

Keywords

reperfusion therapy; pre-hospital triage

Outcome Measures

Primary Outcomes (1)

• Modified rankin scale (mRS) scores of 0-2 at 90 days after reperfusion therapy

  90 days

Secondary Outcomes (7)

• Modified rankin scale (mRS) scores of 0-1 at 90 days after reperfusion therapy

  90 days

• Modified rankin scale (mRS) scores of 0-3 at 90 days after reperfusion therapy

  90 days

• Ordinal analysis of modified rankin scale (mRS) scores at 90 days after reperfusion therapy

  90 days

• Time interval between onset to treatment

  1 day

• Time interval between onset to hospital

  1 day

Study Arms (2)

Ali Pay intelligent navigation applet group

EXPERIMENTAL

Patients in regions with Ali Pay intelligent navigation applet being released would be classified as experimental arm. In this arm, patients have access to this applet. The intelligent navigation applet comprises of three function modules: 1. Stroke knowledge public education: information regarding prevention and emergency treatment of stroke would be push to users' mobile phones regularly; 2. Stroke recognition: questionaires, voice interaction, and facial recognition are employed to identify patients with AIS and large vessel occlusion; 3. Hospital recommendation: this module combines real-time traffic and average in-hopital delay of each stroke center nearby, recommending the stroke center in which patients are mostly likely to receive reperfusion therapy

Routine pre-hospital triage

NO INTERVENTION

Patients in regions without Ali Pay intelligent navigation applet being released would be classified as control arm. In this arm, patients do not have access to this applet.

Interventions

Ali Pay intelligent navigation applet DEVICE

The intelligent navigation applet comprises of three function modules: 1. Stroke knowledge public education: information regarding prevention and emergency treatment of stroke would be push to users\' mobile phones regularly; 2. Stroke recognition: questionaires, voice interaction, and facial recognition are employed to identify patients with AIS and large vessel occlusion; 3. Hospital recommendation: this module combines real-time traffic and average in-hopital delay of each stroke center nearby, recommending the stroke center in which patients are mostly likely to receive reperfusion therapy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients diagnosed as acute ischemic stroke undergoing reperfusion therapy within 24 hours of onset

You may not qualify if:

• Patients transported to hospitals via emergency medical service
• Patients with in-hospital stroke

Sponsors & Collaborators

• Second Affiliated Hospital, School of Medicine, Zhejiang University: lead

Study Sites (1)

Shaoxing People's Hospital

Shaoxing, Zhejing, 312000, China

RECRUITING

MeSH Terms

Conditions

Ischemic Stroke

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Min Lou, PhD, MD

CONTACT

86057187783777; lm99@zju.edu.cn

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: September 23, 2024
• First Posted: September 25, 2024
• Study Start: April 1, 2025
• Primary Completion: May 1, 2026
• Study Completion: May 1, 2026
• Last Updated: August 8, 2025

Record last verified: 2024-09

Locations

CN (1)