Timing and Facilitation Effects of Theta-Burst Stimulation in the Reading and Language Networks

NCT06608680 | Recruiting

• 1 other identifier: H23282
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to understand how transcranial magnetic stimulation affects how quickly, easily, and accurately a person read. Transcranial magnetic stimulation is a technique that uses magnetic fields to briefly affect how well certain brain regions function. The investigators would like to better understand how long the effects of transcranial magnetic stimulation occur in the reading system and at what point the effect is strongest in this system. The main questions it aims to answer are:

• undergo reading, language, and cognitive testing
• receive an MRI
• receive TMS stimulation
• perform language, reading, and motor tasks

Conditions

Reading; Language; Control Subjects

Keywords

transcranial magnetic stimulation; TMS; MRI; Reading; Language

Outcome Measures

Primary Outcomes (1)

• Phonological Decoding Reaction Time

  Four time points after each stimulation (20, 40, 60 and 80 minutes after stimulation)

Study Arms (2)

iTBS/Sham

EXPERIMENTAL

Adults age 18-30 with typical reading and language abilities

Behavioral: iTBS; Behavioral: Sham Stimulation

cTBS/Sham

EXPERIMENTAL

Adults age 18-30 with typical reading and language abilities

Behavioral: cTBS; Behavioral: Sham Stimulation

Interventions

iTBS BEHAVIORAL

Excitatory stimulation of supramarginal gyrus

iTBS/Sham

cTBS BEHAVIORAL

Inhibitory stimulation to supramarginal gyrus

cTBS/Sham

Sham Stimulation BEHAVIORAL

Sham stimulation of supramarginal gyrus

cTBS/Sham; iTBS/Sham

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Subjects must have a minimum of low average intellectual functioning (\>=80) on at least one subscale on the Wechsler Abbreviated Scale of Intelligence-2 (WASI-2; Wechsler, 2011) to be included.
• Within a normal range of reading skills as \>85 on the Test of Word Reading Efficiency - Second Edition (TOWRE-2; Torgesen et al., 2012) and the Woodcock-Johnson IV Tests of Achievement (WJ-IV; Schrank et al., 2014)
• Individuals with a documented history of learning disability will not be included. This will be determined via demographics questionnaire.
• Subjects must be between the ages of 18 and 30 to be included. This will be determined via demographics questionnaire.
• Because reading is critically linked to language, only individuals who are native speakers of English will be included in the study. This will be determined via demographics questionnaire.
• The reading network is typically localized to the left side of the brain. However, left-handed individuals may have different brain lateralization, introducing an important confound to the study. Therefore, only right-handed individuals will be included in the study. This will be determined via demographics questionnaire.
• Individuals who have hearing deficits (\>25dB at 500+ Hz), visual deficits (\>20/40), serious emotional problems, certain neurological conditions (e.g., uncontrolled seizure disorders) will not be included. This will be determined via CABI Screening Forms and Demographics Questionnaire.
• Individuals with certain metals in their bodies or with certain health conditions will not be included. If an individual has braces on their teeth, a cardiac pacemaker; hearing aid; other metal in their body or eyes (which may include certain metallic-embedded tattoos), including but not limited to pins, screws, shrapnel, plates, dentures or other metal objects they will not be included. This will be determined via CABI Screening forms.
• Individuals with MRI Screening and Contraindication Forms which do not pass MRI Tech review will not be included.
• Individuals with TMS Screening Forms which do not pass TMS Tech review will not be included.

Sponsors & Collaborators

• Georgia State University: lead

Study Sites (1)

Georgia State University

Atlanta, Georgia, 30303, United States

RECRUITING

MeSH Terms

Conditions

Language

Condition Hierarchy (Ancestors)

Communication; Behavior

Central Study Contacts

Rachael Harrington, Ph.D. CCC-SLP

CONTACT

404-413-6219; rharrington2@gsu.edu

C. Nikki Arrington, Ph.D.

CONTACT

404-385-8621; carrington3@gsu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: September 12, 2024
• First Posted: September 23, 2024
• Study Start: May 1, 2023
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2028
• Last Updated: September 23, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will share

Locations

US (1)