NCT06606249

Brief Summary

Prrospective, multi-center, randomized controlled trial of a brief, transdiagnostic, guided self-help intervention (Self-Help Plus) for university students who experience significant distress and are behind on their coursework. The intervention will be tested in terms of efficacy and feasibility for outcomes related to distress, anxiety, depression and well-being, assessed immediately after the intervention and at 3-months follow-up.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
210

participants targeted

Target at P75+ for not_applicable

Timeline
9mo left

Started Mar 2025

Typical duration for not_applicable

Geographic Reach
1 country

3 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress61%
Mar 2025Jan 2027

First Submitted

Initial submission to the registry

September 11, 2024

Completed
9 days until next milestone

First Posted

Study publicly available on registry

September 20, 2024

Completed
6 months until next milestone

Study Start

First participant enrolled

March 10, 2025

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2026

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2027

Last Updated

March 13, 2026

Status Verified

March 1, 2026

Enrollment Period

1.6 years

First QC Date

September 11, 2024

Last Update Submit

March 11, 2026

Conditions

Keywords

preventionuniversity studentsacademic deceitemotion regulation

Outcome Measures

Primary Outcomes (1)

  • Kessler psychological distress scale

    The Kessler psychological distress scale (K-10) is a simple measure of psychological distress. It consists of 10 questions about emotional states that can be answered from 1 (none of the time) to 5 (all of the time). Scores of the 10 items are then summed, yielding a minimum score of 10 and a maximum score of 50.

    Baseline, After the intervention, At 3 months after the intervention

Secondary Outcomes (5)

  • Patient Health Questionnaire-9

    Baseline, After the intervention, At 3 months after the intervention

  • The Generalized Anxiety Disorder-7

    Baseline, After the intervention, At 3 months after the intervention

  • World Health Organization Well-Being Index

    Baseline, After the intervention, At 3 months after the intervention

  • Numbers of exams sustained

    Baseline, After the intervention, At 3 months after the intervention

  • Academic deceit survey

    Baseline, After the intervention, At 3 months after the intervention

Other Outcomes (2)

  • Accesibility

    Immediately after the intervention

  • Intervention dose

    Immediately after the intervention

Study Arms (2)

Self-Help Plus (SH+)

EXPERIMENTAL

The intervention is available in its individual online self-help version called "Doing What Matters in Time of Stress". It composed of an illustrate guide, divided into sessions, and pre-recorded audio. Participants will be required to access an online platform for attending the sessions. A total of 5 sessions of approximately an hour each are planned. Participants will be guided by facilitators with minimal qualifications and skills in providing psychosocial support. They will receive regular reminders and instructions from helpers at the beginning of the program and before any sessions via phone call, teleconferencing meeting, or message. Facilitators will receive brief training from specialized mental health professionals trained by WHO.

Behavioral: Self-Help Plus (SH+)

Psychological First Aid (PFA)

ACTIVE COMPARATOR

Psychological First Aid will also be delivered by facilitators through a phone call or teleconferencing meeting, for an approximate ranging from 20 to 45 minutes. Participants will also receive an information sheet with details about mental health services available for students experiencing distress at each of the centers.

Behavioral: Psychological First Aid (PFA)

Interventions

Self-Help Plus is a novel, brief, low-intensity intervention, recently developed by the World Health Organization (WHO) and intended to help people with and without mental disorders cope with distress stemming from diverse types of adversity.The key components of the program are based on acceptance and commitment therapy (ACT), a distinct form of cognitive-behavioural therapy. SH+ draws on ACT techniques of coping with stress, compassion and acceptance toward oneself and others, and living following one's values. An online version called "Doing what matters in times of stress" is available as an illustrated guide and pre-recorded audio.

Also known as: Doing what matters in times of stress
Self-Help Plus (SH+)

Psychological First Aid (PFA) is also developed by the WHO and is a general supportive intervention, aimed at listening and understanding the needs and concerns of people, providing support without pressuring them to talk.

Psychological First Aid (PFA)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • University students across all years of higher education (i.e., bachelor and masters), enrolled in any degree course, starting from the second semester of the 1st year
  • Currently behind coursework by at least 3 exams, including: exams failed, for which the obtained grade was not confirmed by the student (i.e., confirming the grade is mandatory in the Italian academic system), or postponed (i.e., not taken in the regularly scheduled period).
  • Experience significant distress as assessed by the Kessler psychological distress scale (K-10) ≥ 16.

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

University of Bari "Aldo Moro"

Bari, Bari, 70121, Italy

NOT YET RECRUITING

University of Padova

Padua, 35131, Italy

RECRUITING

Universita di Verona

Verona, Italy

RECRUITING

MeSH Terms

Conditions

Psychological Well-BeingDepressionAnxiety DisordersEmotional Regulation

Interventions

Psychological First Aid

Condition Hierarchy (Ancestors)

Personal SatisfactionBehaviorBehavioral SymptomsMental DisordersSelf-ControlSocial Behavior

Intervention Hierarchy (Ancestors)

Emergency Services, PsychiatricMental Health ServicesBehavioral Disciplines and Activities

Study Officials

  • Ioana Cristea, PhD

    University of Padova

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Masking Details
The three site investigators will not be made aware of the block size or have any access to the randomization schedule. The software allows for random allocation of participants after the baseline evaluation is performed and inclusion criteria are checked. The study statistician will also be blinded to group allocation.
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: The study will involve three centers (Padova, Verona, Bari). Randomization will be individual and stratified by the three recruiting center, with an allocation rate of 1:1:1. A centralized system (Redcap) will be used to generate the randomization schedule, using randomly permuted blocks of unequal size.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

September 11, 2024

First Posted

September 20, 2024

Study Start

March 10, 2025

Primary Completion (Estimated)

October 1, 2026

Study Completion (Estimated)

January 1, 2027

Last Updated

March 13, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will share

Fully anonymized and de-identified individual participant data will be made available, following a request and the signing of a data sharing agreement, completed by the data requestor and directed to the principal investigator. Complete metadata and analysis scripts will be made publicly available with each publication. Individual participant data will be made available for research purposes only, including replication. The data will not be made available for non-research purposes in accordance with the legal framework underpinning ethical approval and informed consent.

Shared Documents
STUDY PROTOCOL, SAP, ICF, ANALYTIC CODE
Time Frame
One year after study completion.
Access Criteria
Interested parties will have to submit a data request including as a minimum the purpose of accessing the data, how the data will be used and how findings will be disseminated. A data sharing agreement will be signed between the requestor and principal investigator underlying the purposes and conditions for which data will be used.

Locations