Phenotypes of Preschool Wheezing Among Children Attending Sohag University Hospital

NCT06603584 | Recruiting

• 1 other identifier: soh-Med-24-06-20MS
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Wheezing in preschool children is very common, with a wide differential diagnosis. It is essential to be sure of the exact sound that parents are describing; the term 'wheeze' is often applied to non-specific sound.Approximately one-third of children are diagnosed with wheeze in the first 3 years of life, making wheeze one of the commonest respiratory symptoms.The differential diagnosis of wheeze is wide, and different management strategies are needed depending on the underlying phenotype. The word 'wheeze' is used to describe many different sounds. That can be heard by both clincians and parent. Even if true wheeze is heard, this should not be automatically assumed to be due to bronchospasm. Airway narrowing by mucus will produce true wheeze but does not respond to bronchodilators. Similarly, airway malacia, either related to intrinsic airway wall defects or loss of alveolar tethering points, are also causes of bronchodilatorunresponsive wheeze; indeed, bronchodilators, by reducing airway smooth muscle tone, may actually worsen airway narrowing.

Conditions

Wheezing

Outcome Measures

Primary Outcomes (1)

• Forced Expiratory Volume

  Changes in Forced Expiratory Volume in bronchial Asthmatic Patient

  6 months

Study Arms (4)

group A

Bronchial Asthma

Radiation: Chest x- Rays

group B

Chronic Aspiration

Radiation: Chest x- Rays

group C

Primary Ciliary Dyskinesia

Radiation: Chest x- Rays

group D

Cystic Fibrosis

Radiation: Chest x- Rays

Interventions

Chest x- Rays RADIATION

prebronchial Thicknening - Right upper lobe Patches suggesting Aspiration -Collapsing lobe

group A; group B; group C; group D

Eligibility Criteria

• Age: 2 Years - 6 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

\- patients from the age of one to five years with recurrent wheezing

You may qualify if:

• patients from the age of one to five years with recurrent wheezing

You may not qualify if:

• Children above 5 years and below one year old.
• Failure to obtain informed consent.
• Children below 6 years with chest diseases other than wheezing

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag university Hospital

Sohag, Egypt

RECRUITING

Related Publications (4)

• Fitzpatrick AM, Bacharier LB, Guilbert TW, Jackson DJ, Szefler SJ, Beigelman A, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Morgan W, Phipatanakul W, Pongracic JA, Zeiger RS, Mauger DT; NIH/NHLBI AsthmaNet. Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation. J Allergy Clin Immunol Pract. 2019 Mar;7(3):915-924.e7. doi: 10.1016/j.jaip.2018.09.016. Epub 2018 Sep 26.

  PMID: 30267890 BACKGROUND

• Lowe LA, Simpson A, Woodcock A, Morris J, Murray CS, Custovic A; NAC Manchester Asthma and Allergy Study Group. Wheeze phenotypes and lung function in preschool children. Am J Respir Crit Care Med. 2005 Feb 1;171(3):231-7. doi: 10.1164/rccm.200406-695OC. Epub 2004 Oct 22.

  PMID: 15502115 BACKGROUND

• Salehian S, Fleming L, Saglani S, Custovic A. Phenotype and endotype based treatment of preschool wheeze. Expert Rev Respir Med. 2023 Jul-Dec;17(10):853-864. doi: 10.1080/17476348.2023.2271832. Epub 2023 Nov 24.

  PMID: 37873657 BACKGROUND

• Kwong CG, Bacharier LB. Phenotypes of wheezing and asthma in preschool children. Curr Opin Allergy Clin Immunol. 2019 Apr;19(2):148-153. doi: 10.1097/ACI.0000000000000516.

  PMID: 30640211 BACKGROUND

MeSH Terms

Conditions

Respiratory Sounds

Interventions

X-Rays

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Electromagnetic Radiation; Electromagnetic Phenomena; Magnetic Phenomena; Physical Phenomena; Radiation; Radiation, Ionizing

Central Study Contacts

Amr A Farghal, resident

CONTACT

01020479524; amrahmed@med.sohag.edu.eg

Mostfa A Mohammed, assistant professor

CONTACT

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident-pediatric department-sohag hospital university

Study Record Dates

• First Submitted: September 17, 2024
• First Posted: September 19, 2024
• Study Start: June 4, 2024
• Primary Completion: April 4, 2025
• Study Completion: April 4, 2025
• Last Updated: September 19, 2024

Record last verified: 2024-09

Locations

EG (1)