Study of the Causal Link Between Rheumatoid Arthritis and Periodontitis Using Mendelian Randomization

NCT06603207 | Not Yet Recruiting

• 1 other identifier: KY20240918-01
• Study Type: observational
• Target: 220,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization. Data will be sourced from genome-wide association studies (GWAS) to explore genetic associations and assess potential risk factors in an East Asian population.

Conditions

Rheumatoid Arthritis; Periodontitis

Keywords

Mendelian Randomization; Genome-Wide Association Study (GWAS); Inflammatory Diseases; Genetic Risk Factors; SNP (Single Nucleotide Polymorphism)

Outcome Measures

Primary Outcomes (1)

• Causal Association Between Rheumatoid Arthritis and Periodontitis

  This study uses Mendelian randomization to evaluate the causal relationship between rheumatoid arthritis (RA) and periodontitis in the East Asian population. The analysis utilizes genome-wide association study (GWAS) data, employing inverse variance weighting (IVW), weighted median, and MR-Egger regression methods to assess the genetic relationship and the risk contribution of RA to the development of periodontitis.

  Data collected from 2023 to 2024.

Secondary Outcomes (1)

• Analysis of Genetic Pleiotropy and Confounders

  2023 to 2024

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study utilizes genetic data from an East Asian population, sourced from publicly available genome-wide association studies (GWAS) focused on rheumatoid arthritis and periodontitis.

You may qualify if:

• Participants included in the genome-wide association study (GWAS) database.
• Subjects with available genotypic data relevant to rheumatoid arthritis and periodontitis.

You may not qualify if:

• Individuals without complete genotypic data or those with missing critical phenotypic information.

Sponsors & Collaborators

• Zhibin Xu: lead
• Zhongshan People's Hospital, Guangdong, China: collaborator

Biospecimen

Retention: SAMPLES WITHOUT DNA

This study uses existing GWAS data for Mendelian randomization analysis and does not involve the collection or retention of biological specimens.

MeSH Terms

Conditions

Arthritis, Rheumatoid; Periodontitis

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Guangzhou Institute of Respiratory Disease

Study Record Dates

• First Submitted: September 17, 2024
• First Posted: September 19, 2024
• Study Start: October 1, 2024
• Primary Completion: November 1, 2024
• Study Completion: December 1, 2024
• Last Updated: September 20, 2024

Record last verified: 2024-09