Congenital Hepatic Fibrosis and Autosomal Recessive Polycystic Kidney Disease in Children at Sohag University Hospital

NCT06601829 | Recruiting

• 1 other identifier: soh-Med-24-08-01MS
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

polycystic kidney disease is aherditary disorder characterized by the formation of numerous fluid filled cysts in the kidneys which can lead to progressive renal impairment PKDencompasses aspectrum of disorders with autosomal dominant polycystic kidneydisease and autosomal recessive polycystic kidney disease being the two main types

Conditions

Congenital Hepatic Fibrosis and Autosomal Recessive Polycystic Kidney Disease in Children at Sohag University Hospital

Outcome Measures

Primary Outcomes (1)

• incidence of congenital hepatic fibrosis in patient with autosomal recessive polycyctic kidney disease

  describe congenital hepatic fibrosis in patient with autosomal recessive polycystic kidney explaining their clinical manifestations.diagnosis.managment and complications

  12 months

Interventions

abdominal ultrasound OTHER

abdominal ulterasound showing multiple cysts in the kidnets and hepatic fibrosis

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

cross sectional study prospective and retrospective

You may qualify if:

• pediatric patients aged 0-18 years both male and female patients

You may not qualify if:

• patients whose guardians dont provide informed consent patients who are not complient with follow up vists and data collection protocols

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag university Hospital

Sohag, Egypt

RECRUITING

Related Publications (5)

• Paul BM, Vanden Heuvel GB. Kidney: polycystic kidney disease. Wiley Interdiscip Rev Dev Biol. 2014 Nov-Dec;3(6):465-87. doi: 10.1002/wdev.152. Epub 2014 Sep 3.

  PMID: 25186187 BACKGROUND

• Salman MA, Elgebaly A, Soliman NA. Epidemiology and outcomes of pediatric autosomal recessive polycystic kidney disease in the Middle East and North Africa. Pediatr Nephrol. 2024 Sep;39(9):2569-2578. doi: 10.1007/s00467-024-06281-0. Epub 2024 Jan 23.

  PMID: 38261064 BACKGROUND

• Khare A, Krishnappa V, Kumar D, Raina R. Neonatal renal cystic diseases. J Matern Fetal Neonatal Med. 2018 Nov;31(21):2923-2929. doi: 10.1080/14767058.2017.1358263. Epub 2017 Aug 2.

  PMID: 28764564 BACKGROUND

• Webster AC, Nagler EV, Morton RL, Masson P. Chronic Kidney Disease. Lancet. 2017 Mar 25;389(10075):1238-1252. doi: 10.1016/S0140-6736(16)32064-5. Epub 2016 Nov 23.

  PMID: 27887750 BACKGROUND

• Lucchetti L, Chinali M, Emma F, Massella L. Autosomal dominant and autosomal recessive polycystic kidney disease: hypertension and secondary cardiovascular effect in children. Front Mol Biosci. 2023 Mar 10;10:1112727. doi: 10.3389/fmolb.2023.1112727. eCollection 2023.

  PMID: 37006611 BACKGROUND

MeSH Terms

Conditions

Hepatic Fibrosis, Congenital

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident-pediatric department-sohag hospital university

Study Record Dates

• First Submitted: September 16, 2024
• First Posted: September 19, 2024
• Study Start: August 1, 2024
• Primary Completion: August 1, 2025
• Study Completion: August 1, 2025
• Last Updated: September 19, 2024

Record last verified: 2024-09

Locations

EG (1)