Ultrasound Findings of Thumb Muscles in 1st Carpometacarpal Osteoarthritis

NCT06600464 | Active Not Recruiting

• 1 other identifier: Gulcanozturk1984
• Study Type: observational
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

Carpometacarpal (CMC) joint osteoarthritis is a disorder that is estimated to affect more than one-third of postmenopausal women, leading to decreased muscle strength, reduced joint range of motion, and pain.The pathogenesis of thumb CMC osteoarthritis involves complex interactions between biomechanical forces, genetic predisposition, hormonal changes, repetitive microtrauma, and aging. An important factor in the progression of carpometacarpal osteoarthritis is the loss of joint stability provided by the surrounding muscles (2). The common methods for diagnosing thumb CMC OA is plain radiographs and clinical examinations. However, radiographs are unable to assess the role of surrounding structures, including muscles and ligaments. Ultrasound is a cost-effective, radiation-free, and easily applicable imaging method.

Conditions

Osteoarthrosis; Ultrasound

Keywords

osteoarthrosis; ultrasound; thenar muscles

Outcome Measures

Primary Outcomes (3)

• ultrasound

  The thickness of the thenar eminence muscles (longitudinal thickness of the first dorsal interosseous muscle (FDI), abductor pollicis brevis (APB), and opponens pollicis (OPP)) was measured using musculoskeletal ultrasound.

  1 day

• Assessment of Muscle Strength in Both Hands

  Participants were seated in a standardized position with their elbows flexed at 90°. Muscle strength in both hands was evaluated using grip strength measured with a dynamometer (Jamar Hydraulic Hand Dynamometer, Nottinghamshire, UK)

  1 day

• Assessment of Pain Threshold

  Pressure pain threshold (PPT) for painful and non-painful finger joints was assessed using a hand-held algometer (FPIX25, with a 1 cm² flat rubber probe).

  1 day

Study Arms (2)

Group 1

Patients with various stages of 1st carpometacarpal (CMC) joint osteoarthritis (OA) were assessed using standard radiographs based on the Modified Eaton Litter classification

Diagnostic Test: Ultrasound; Other: Assessment of Muscle Strength in Both Hands; Other: Assessment of Pain Threshold

Group 2

In the healthy control group, subjects were matched based on age and hand dominance

Diagnostic Test: Ultrasound; Other: Assessment of Muscle Strength in Both Hands; Other: Assessment of Pain Threshold

Interventions

Ultrasound DIAGNOSTIC_TEST

The thickness of the thenar eminence muscles (longitudinal thickness of the first dorsal interosseous muscle (FDI), abductor pollicis brevis (APB), and opponens pollicis (OPP)) was measured using musculoskeletal ultrasound.

Group 1; Group 2

Assessment of Muscle Strength in Both Hands OTHER

Muscle strength in both hands was evaluated using grip strength measured with a dynamometer (Jamar Hydraulic Hand Dynamometer, Nottinghamshire, UK)

Group 1; Group 2

Assessment of Pain Threshold OTHER

Pressure pain threshold (PPT) for painful and non-painful finger joints was assessed using a hand-held algometer

Group 1; Group 2

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Postmenopausal women with clinical and/or radiological evidence of 1st CMC OA

You may qualify if:

• Postmenopausal women with clinical and/or radiological evidence of 1st CMC OA

You may not qualify if:

• De Quervain\'s tenosynovitis, flexor carpi radialis tendon pathology, and carpal tunnel syndrome, as well as those with hand trauma or hand surgery within the past year, had received steroid and local anesthetic injections into the 1st CMC joint within the last 3 months, or had connective tissue disorders, rheumatologic, or autoimmune diseases

Sponsors & Collaborators

• Fatih Sultan Mehmet Training and Research Hospital: lead

Study Sites (1)

Gulcan Ozturk

Istanbul, Atasehir, 34752, Turkey (Türkiye)

Location

Related Publications (2)

• Mohseny B, Nijhuis TH, Hundepool CA, Janssen WG, Selles RW, Coert JH. Ultrasonographic quantification of intrinsic hand muscle cross-sectional area; reliability and validity for predicting muscle strength. Arch Phys Med Rehabil. 2015 May;96(5):845-53. doi: 10.1016/j.apmr.2014.11.014. Epub 2014 Dec 4.

  PMID: 25482051 RESULT

• Pickrell BB, Eberlin KR. Thumb Basal Joint Arthritis. Clin Plast Surg. 2019 Jul;46(3):407-413. doi: 10.1016/j.cps.2019.02.010.

  PMID: 31103085 RESULT

Related Links

• Pickrell BB, Eberlin KR. Thumb Basal Joint Arthritis.
• Ultrasonographic quantification of intrinsic hand muscle cross-sectional area; reliability and validity for predicting muscle strength

MeSH Terms

Conditions

Osteoarthritis

Interventions

Ultrasonography

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 14, 2024
• First Posted: September 19, 2024
• Study Start: August 31, 2024
• Primary Completion: November 30, 2024
• Study Completion: December 31, 2024
• Last Updated: September 19, 2024

Record last verified: 2024-09

Locations

TU (1)