Myocardial Bridging in Obstructive Hypertrophic Cardiomyopathy

NCT06598995 | Completed

• 2 other identifiers: 2022-18922022-GSP-GG-29
• Study Type: observational
• Target: 968
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigated the impact of myocardial bridging (MB) and its characteristics on preoperative atrial fibrillation and survival in patients with obstructive hypertrophic cardiomyopathy (oHCM). We recruited 968 consecutive patients with oHCM who underwent myectomy at our institution between January 2015 and December 2019, including 144 patients with MB and 824 patients without MB. All patients received angiography before surgery. The diagnosis of preoperative atrial fibrillation was based on 12-lead electrocardiography, 24-hour Holter electrocardiography, or in-hospital electrocardiogram monitoring, which was extracted from patients' medical records. Surgical details and follow-up data were also collected.

Conditions

Myocardial Bridging; Obstructive Hypertrophic Cardiomyopathy; Atrial Fibrillation (AF)

Outcome Measures

Primary Outcomes (1)

• All-cause death

  Any death occurred one month after discharge

  One month after discharge

Secondary Outcomes (2)

• New-onset AF

  One month after discharge.

• Composite endpoints

  One month after discharge

Study Arms (1)

Obstructive hypertrophic cardiomyopathy who underwent septal myectomy

All patients underwent angiography and without other coronary artery disease.

Procedure: Coronary artery bypass grafting or unroofing

Interventions

Coronary artery bypass grafting or unroofing PROCEDURE

Patients had an MB with \>75% compression degree would receive coronary artery bypass grafting, and those who underwent unroofing may had a depth of MB \< 5mm (whether deal with these MB with a depth \<5mm depends on the surgeon and the period time of patients received a surgery).

Obstructive hypertrophic cardiomyopathy who underwent septal myectomy

Eligibility Criteria

• Age: 18 Years+
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients diagnosed with obstructive hypertrophic cardiomyopathy who underwent septal myectomy.

Sponsors & Collaborators

• Chinese Academy of Medical Sciences, Fuwai Hospital: lead

Study Sites (1)

Fuwai Hospital

Beijing, Please Select, 475, China

Location

MeSH Terms

Conditions

Myocardial Bridging; Cardiomyopathy, Hypertrophic; Atrial Fibrillation

Interventions

Coronary Artery Bypass

Condition Hierarchy (Ancestors)

Coronary Vessel Anomalies; Heart Defects, Congenital; Cardiovascular Abnormalities; Cardiovascular Diseases; Heart Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiomyopathies; Aortic Stenosis, Subvalvular; Aortic Valve Stenosis; Aortic Valve Disease; Heart Valve Diseases; Arrhythmias, Cardiac; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Myocardial Revascularization; Cardiac Surgical Procedures; Cardiovascular Surgical Procedures; Surgical Procedures, Operative; Vascular Grafting; Vascular Surgical Procedures; Thoracic Surgical Procedures

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: September 12, 2024
• First Posted: September 19, 2024
• Study Start: January 1, 2022
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)