NCT06593652

Brief Summary

Intervention for mild severity alcohol use among U.S. teens is crucial, as alcohol is the most commonly used substance in this age group, yet few receive the necessary interventions. Primary care, where over 90% of youth regularly visit, is an ideal setting for identifying and addressing mild alcohol use disorder (AUD) through brief interventions like motivational interviewing (MI) and cognitive-behavioral therapy (CBT). However, for teens with mild AUD, a single brief session may not be sufficient, raising questions about the role of caregiver involvement. This study seeks to determine the most effective level of caregiver involvement-no involvement, a single live session, or an online self-paced program-in reducing alcohol use among adolescents with mild AUD in primary care settings. The study also explores the impact of these interventions on other outcomes such as substance use and psychosocial functioning, as well as the factors influencing treatment response. The results will guide the selection and implementation of effective, scalable interventions in primary care to address youth alcohol use disorders.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
615

participants targeted

Target at P75+ for not_applicable

Timeline
28mo left

Started Aug 2025

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress24%
Aug 2025Sep 2028

First Submitted

Initial submission to the registry

August 28, 2024

Completed
22 days until next milestone

First Posted

Study publicly available on registry

September 19, 2024

Completed
11 months until next milestone

Study Start

First participant enrolled

August 19, 2025

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2028

Last Updated

January 2, 2026

Status Verified

October 1, 2025

Enrollment Period

3 years

First QC Date

August 28, 2024

Last Update Submit

December 29, 2025

Conditions

Keywords

Brief InterventionTeen InterveneCaregiver InvolvementAlcohol UseSubstance Use

Outcome Measures

Primary Outcomes (1)

  • Timeline Follow-Back

    30 items that assess daily alcohol usage over the past month will be administered to all participants. Participants will be queried about number of standard drinks consumed each day.

    *0-at time of intervention, *3 months after time of intervention; *6 months after time of intervention; *12 months after time of intervention

Secondary Outcomes (4)

  • Timeline Follow-Back

    *0-at time of intervention, *3 months after time of intervention; *6 months after time of intervention; *12 months after time of intervention

  • DAST-A

    *0-at time of intervention, *3 months after time of intervention; *6 months after time of intervention; *12 months after time of intervention

  • SUD Services Engagement

    *0-at time of intervention, *3 months after time of intervention; *6 months after time of intervention; *12 months after time of intervention

  • PROMIS Surveys

    *0-at time of intervention, *3 months after time of intervention; *6 months after time of intervention; *12 months after time of intervention

Other Outcomes (3)

  • Client Satisfaction Questionnaire

    *0-at time of intervention, *3 months after time of intervention; *6 months after time of intervention; *12 months after time of intervention

  • Communities That Care Survey Family Factors

    *0-at time of intervention, *3 months after time of intervention; *6 months after time of intervention; *12 months after time of intervention

  • Acceptability, Feasibility, and Appropriateness of Intervention Measure

    once a year

Study Arms (3)

Teen Intervene - Adolescent Only

ACTIVE COMPARATOR

Only the youth will participate in the brief intervention, Teen Intervene. The youth will participate in manual-standardized Teen Intervene sessions.

Behavioral: Teen Intervene - Adolescent Only

Teen Intervene - Caregiver Involvement

EXPERIMENTAL

The youth will participate in two Teen Intervene sessions. Additionally, the caregiver(s) will participate in a single, caregiver-only Teen Intervene session.

Behavioral: Teen Intervene with Caregiver Session

Teen Intervene - Online Caregiver Support Tool

EXPERIMENTAL

Only the youth will participate in the brief intervention, Teen Intervene. The youth will participate in two Teen Intervene sessions. Caregiver(s) will be provided with an online tool (Family Checkup Online) that addresses parenting strategies to support their youth.

Behavioral: Family Check Up

Interventions

Teen Intervene (TI) is delivered over two or three, 45- to 60-minute sessions (2 teen sessions +/- 1 caregiver session) to reduce youth substance use, increase motivation for abstinence, and promote use of existing coping strategies. TI is an adolescent-appropriate adaptation of motivational enhancement therapy (MET), and includes a discussion of readiness to change, goal setting, personal feedback, a functional analysis of substance use, and a review of coping skills.

Teen Intervene - Adolescent Only

Teen Intervene (TI) is delivered over two or three, 45- to 60-minute sessions (2 teen sessions +/- 1 caregiver session) to reduce youth substance use, increase motivation for abstinence, and promote use of existing coping strategies. TI is an adolescent-appropriate adaptation of motivational enhancement therapy (MET), and includes a discussion of readiness to change, goal setting, personal feedback, a functional analysis of substance use, and a review of coping skills. In this condition, the caregiver session will address caregiver expectations around youth substance use and strategies for promoting positive youth behavior change including reduced substance use.

Teen Intervene - Caregiver Involvement
Family Check UpBEHAVIORAL

Family Check-Up Online (FCU-O) is a self-paced, parent-driven, fully HIPAA compliant online version of the Family Check-Up (FCU), a brief intervention that integrates assessment, motivation-enhancement, and skill building to help parents effectively manage behavior and build positive relationships with their children aged 2-17 in order to reduce emotional and behavioral problems among youth.

Teen Intervene - Online Caregiver Support Tool

Eligibility Criteria

Age12 Years - 17 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • years old;
  • Mild to moderate severity for alcohol use (based on standardized surveys from their primary care provider or clinical indication) or other substance use
  • English language fluency

You may not qualify if:

  • N/A

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

IU Health/Indiana University School of Medicine

Indianapolis, Indiana, 46112, United States

RECRUITING

MeSH Terms

Conditions

Alcohol DrinkingSubstance-Related Disorders

Condition Hierarchy (Ancestors)

Drinking BehaviorBehaviorChemically-Induced DisordersMental Disorders

Study Officials

  • Zachary Adams, PhD, HSPP

    Indiana University

    PRINCIPAL INVESTIGATOR
  • Tamika Zapolski, PhD, HSPP

    Indiana University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

SPARC Research Team

CONTACT

Zachary Adams, PhD, HSPP

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
The data analysts will be masked to intervention condition.
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

August 28, 2024

First Posted

September 19, 2024

Study Start

August 19, 2025

Primary Completion (Estimated)

September 1, 2028

Study Completion (Estimated)

September 1, 2028

Last Updated

January 2, 2026

Record last verified: 2025-10

Data Sharing

IPD Sharing
Will not share

Though the researchers are not required to provide information about plans to share individual participant data (IPD), we plan to withhold individual participant data from sharing. This decision aligns with university policy and the terms outlined in our participants\' consent forms, which stipulate that patient information will not be shared publicly.

Locations