Clinical and Surgical Outcomes of Thyroid Carcinoma in Children and Adolescents

NCT06592118 | Completed

• 1 other identifier: DZSRMYYZC2024095
• Study Type: observational
• Target: 3,068
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to investigate the differences in clinical characteristics, causes of death, long-term survival, and surgical approaches between pediatric and adolescent follicular and papillary carcinoma by exploring data from the SEER database. The research is designed as a retrospective cohort study, primarily focused on collecting and comparing data to identify key disparities and outcomes between these two patient groups. It is anticipated that the findings will provide valuable insights into the management and prognosis of these cancers in younger populations, contributing to more targeted and effective treatment strategies.

Conditions

Pediatric and Adolescent Differentiated Thyroid Carcinoma; SEER Database Analysis

Outcome Measures

Primary Outcomes (4)

• Overall Survival (OS)

  Time from diagnosis until death from any cause.

  Up to 20 years post-diagnosis

• T (Tumor) - Primary Tumor

  T describes the size and/or extent of the primary tumor, T values typically range from T0 to T4, where T0 indicates no evidence of a primary tumor (not detectable), and T4 indicates a large tumor that has significantly invaded surrounding tissues.

  Perioperatively/Periprocedurally

• N (Nodes) - Regional Lymph Nodes

  The N staging will classify the extent of lymph node involvement as follows: N0 indicates no lymph node metastasis, N1a indicates metastasis to central compartment lymph nodes, and N1b indicates metastasis to lateral neck lymph nodes.

  Perioperatively/Periprocedurally

• M (Metastasis) - Distant Metastasis

  M describes whether cancer has spread to other parts of the body (distant metastasis). M values are usually M0 or M1, where M0 indicates no distant metastasis, and M1 indicates the presence of distant metastasis.

  Within one month after the diagnosis of thyroid carcinoma

Study Arms (2)

FTC

Pediatric and Adolescent Patients with Follicular Thyroid Carcinoma

Other: Different Pathological Types (FTC vs PTC)

PTC

Pediatric and Adolescent Patients with Papillary Thyroid Carcinoma

Other: Different Pathological Types (FTC vs PTC)

Interventions

Different Pathological Types (FTC vs PTC) OTHER

Comprehensive Comparison of Pediatric and Adolescent Follicular Thyroid Carcinoma and Papillary Thyroid Carcinoma Patients

Also known as: Different Pathological Types

FTC; PTC

Eligibility Criteria

• Age: 1 Year - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of pediatric and adolescent patients, aged 1 to 18 years, who have been diagnosed with Follicular Thyroid Carcinoma (FTC) or Papillary Thyroid Carcinoma (PTC). These patients were identified from a comprehensive database containing clinical, pathological, and surgical records.The population spans a diverse demographic, representing various ethnicities, genders, and geographical locations. This cohort was selected to ensure a thorough investigation of the differences in clinical presentations, surgical outcomes, and prognostic factors between the two types of thyroid carcinoma within the pediatric and adolescent age groups.

You may qualify if:

• Pathologically confirmed diagnosis of Follicular Thyroid Carcinoma (FTC) or Papillary Thyroid Carcinoma (PTC).
• Age range: Pediatric and adolescent patients (ages 1-18 years).

You may not qualify if:

• Patients with incomplete survival and clinical information.

Sponsors & Collaborators

• Dezhou Hospital Qilu Hospital of Shandong University: lead

Related Publications (4)

• Cistaro A, Quartuccio N, Garganese MC, Villani MF, Altini C, Pizzoferro M, Piccardo A, Cabria M, Massollo M, Maghnie M, Campenni A, Siracusa M, Baldari S, Panareo S, Urso L, Bartolomei M, De Palma D, Grossi A, Mazzoletti A, Dondi F, Bertagna F, Giubbini R, Albano D. Prognostic factors in children and adolescents with differentiated thyroid carcinoma treated with total thyroidectomy and RAI: a real-life multicentric study. Eur J Nucl Med Mol Imaging. 2022 Mar;49(4):1374-1385. doi: 10.1007/s00259-021-05586-8. Epub 2021 Oct 19.

  PMID: 34664092 BACKGROUND

• de Souza Reis R, Gatta G, de Camargo B. Thyroid carcinoma in children, adolescents, and young adults in Brazil: A report from 11 population-based cancer registries. PLoS One. 2020 May 1;15(5):e0232416. doi: 10.1371/journal.pone.0232416. eCollection 2020.

  PMID: 32357198 BACKGROUND

• Moleti M, Aversa T, Crisafulli S, Trifiro G, Corica D, Pepe G, Cannavo L, Di Mauro M, Paola G, Fontana A, Calapai F, Cannavo S, Wasniewska M. Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis. Front Endocrinol (Lausanne). 2023 Sep 19;14:1270518. doi: 10.3389/fendo.2023.1270518. eCollection 2023.

  PMID: 37795368 BACKGROUND

• Liu Y, Meng T, Ma S, Zheng Y, Miao Y, Zhang T. Clinical characteristics, surgical approaches, and prognosis of follicular and papillary thyroid cancer in children and adolescents: a retrospective cohort study. Pediatr Surg Int. 2025 Feb 28;41(1):89. doi: 10.1007/s00383-025-05990-3.

  PMID: 40019558 DERIVED

Study Officials

• Tao Zhang, MD

  Qilu Hospital of Shandong University Dezhou

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 4, 2024
• First Posted: September 19, 2024
• Study Start: January 1, 2000
• Primary Completion: December 31, 2020
• Study Completion: August 31, 2024
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: Data will be available beginning 6 months after publication of the main study results and will be accessible for a period of 2 years.
• Access Criteria: Researchers seeking access to the IPD must submit a methodologically sound proposal. Requests should be directed to the principal investigator and will be evaluated on the basis of scientific merit and ethical considerations.