Exploration of Gender Differences in Liver Aging

NCT06591897 | Recruiting

• 1 other identifier: 2024-0815
• Study Type: observational
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

The liver is an important metabolic organ in the body. It participates in central metabolic activities to maintain systemic homeostasis. It is also one of the most vulnerable organs in the process of individual aging. During aging, the volume, blood flow, metabolic capacity and regenerative capacity of the liver decrease. Liver function changes with age can lead to age-related systemic susceptibility diseases. Therefore, understanding the changes of metabolism and immune function in the process of liver aging and studying the regulation mechanism of liver aging will provide an important reference for understanding the causes of increased susceptibility to liver-related diseases in the elderly population.On the other hand, gender factors also affect organ function, leading to differences in human aging and disease outcomes.At present, the omics research on liver aging is mainly based on tissue-level transcription, protein or metabolomics, and most of the conclusions are focused on hepatocytes. However, for other cell types and microenvironment interactions, people know little about the aging changes at the cellular levelBased on the current research status, this study aims to explore the gender differences in the process of liver aging, using emerging technologies such as the combination of single-cell multi-omics and spatial localization, to reveal the factors driving liver aging from a gender perspective, and to promote the development of accurate interventions for aging and aging-related diseases.

Conditions

Healthy Population

Keywords

hepatocyte; liver function; sex differences

Outcome Measures

Primary Outcomes (1)

• Molecular and cellular characteristics during liver aging

  Draw the map information of liver aging single cell precision, and clarify whether the effect of aging on liver cell types has gender differences.

  2027.08

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

In this study, the normal liver sampling criteria are as follows : 1.Preoperative blood biochemical liver function indicators are in the normal reference range. 2.Liver imaging is normal. The liver is normal in size, regular in shape, smooth in capsule, uniform in parenchymal echo, and intrahepatic vascular network. For patients undergoing laparoscopic cholecystectomy, the liver tissue of the IV segment of the liver ( about 1mm3 ) was separated from the gallbladder wall specimen.

You may qualify if:

• Liver function indicators are in the normal reference range.
• Liver imaging examination showed normal.

You may not qualify if:

• Patients with previous liver-related diseases.
• Subjects with important organ dysfunction / failure or other serious diseases ( myocardial infarction, malignant tumor, severe neurological or psychiatric history, severe infection, coagulation dysfunction, etc. )
• Moderate malnutrition ( BMI \< 17kg / m2 ) and severe anemia ( Hb \< 60g / L ).
• Subjects and their families who disagreed with the study protocol.

Sponsors & Collaborators

• Second Affiliated Hospital, School of Medicine, Zhejiang University: lead

Study Sites (1)

2nd Affiliated Hospital, School of Medicine, Zhejiang University, China

Hangzhou, Zhejiang, No.88 Jiefang Road, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Liver tissue of segment IV ( about 1mm³ )

Study Officials

• daren Liu, MD, PhD

  Zhejiang University

  STUDY DIRECTOR

Central Study Contacts

daren Liu, MD, PhD

CONTACT

15968179036; darenliu@zju.edu.cn

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 8, 2024
• First Posted: September 19, 2024
• Study Start: September 27, 2024
• Primary Completion (Estimated): September 15, 2027
• Study Completion (Estimated): September 20, 2027
• Last Updated: October 8, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)