Twelve Weeks of Resistance Training is Equally As Effective At Improving Cardiovascular Risk Factors in Older Women with and Without Depression: a Non-randomized Cross-over Trial

NCT06591325 | Completed

• 1 other identifier: GEPEMENE 2024
• Study Type: interventional
• Target: 79
• Locations: 1 country
• Sites: 1

Brief Summary

Background: the purporse was to evaluate and compare the effects of 12 weeks of resistance training (RT) on cardiovascular disease (CVD) risk factors in older women with and without depressive disorders Methods: We included 79 older women, 52 without depressive disorders and 27 with a diagnosis of depressive disorders. The 79 participants passed through 12 weeks of control condition and were instructed to maintain their habitual routine. After the control period, the participants were reevaluated and attended 12 weeks of RT. The Beck Anxiety Inventory (BAI) and Patient Health Questionnaire-9 (PHQ-9) were used to measure anxiety and depressive symptoms, respectively. The serum levels of high-sensitivity C-reactive protein, glucose, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density cholesterol (LDL-c), and triglycerides (TG) were used as cardiovascular risk factors. The Linear Mixed Model (LMM) was used to compare between groups.

Conditions

Depressive Symptoms; Aging; Resistance Training; Cardiovascular Risk Factor

Keywords

strength training; depressive symptoms; anxiety symptoms; cardiovascular risk factor

Outcome Measures

Primary Outcomes (1)

• Cardiovascular risk factors

  Blood sample (venous) was collected in a tube containing a dipotassium ethylenediaminetetraacetic acid (12 ml, vacuum-sealed system; Vacutainer, England) between 7:00 and 9:00 a.m. by a trained laboratory technician after an overnight fast of at least 12 h. Participants rested in a seated position for at least five minutes before withdrawing 5 ml of blood from a prominent superficial vein in the antecubital space. All samples were centrifuged at 3,000 rpm for 15 min, and plasma or serum aliquots were stored at -80° C until assayed. As determined in human plasma, inter- and intra-assay coefficients of variation were \< 10%.

  From begining to the end 12 weeks

Study Arms (2)

exercise group = participants performed 12 weeks of strength training

EXPERIMENTAL

Other: exercise; Other: Control

control group = participants maintained their usual activities normally

NO INTERVENTION

Interventions

exercise OTHER

The RT program was performed in the morning and in groups, three days per week (Mondays, Wednesdays, and Fridays), in the University fitness facility over 12 weeks. Participants were personally supervised by Physical Education professionals (1-2 supervisors per exercise session) with substantial RT experience to ensure consistent and safe exercise performance. Throughout the intervention period, the RT program was carried out on machines and free weights (Ipiranga Fitness, Presidente Prudente, SP, Brazil). The training program was carried out in groups. Participants performed four exercises for the trunk and upper limbs (chest press, seated row, triceps pushdown, preacher curl) and four exercises for the lower limbs (horizontal leg press, leg extension, lying leg curl, seated calf raise) in three sets of 10-15 repetitions based on previous guidelines (9,22).

exercise group = participants performed 12 weeks of strength training

Control OTHER

maintaining the daily routine

exercise group = participants performed 12 weeks of strength training

Eligibility Criteria

• Age: 60 Years+
• Gender Eligibility Details: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• females aged \> 60 years;
• physically independent;
• had no cardiac, orthopedic, or musculoskeletal dysfunction that could impede physical exercise;
• not having uncontrolled diabetes mellitus or hypertension;
• not be involved in the practice of regular physical activity performed more than once a week over the three months before the start of the study;
• present the medical clearance from a cardiologist (resting 12-lead electrocardiogram test, personal interview, and treadmill stress test when deemed necessary) to attend RT without restriction.

You may not qualify if:

• not reaching 85% of training sessions

Sponsors & Collaborators

• Universidade Estadual de Londrina: lead

Study Sites (1)

State University of Londrina

Londrina, Paraná, 86057-970, Brazil

Location

MeSH Terms

Conditions

Depression; Anxiety Disorders

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior; Mental Disorders

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: September 4, 2024
• First Posted: September 19, 2024
• Study Start: November 2, 2021
• Primary Completion: July 25, 2022
• Study Completion: July 25, 2022
• Last Updated: September 19, 2024

Record last verified: 2024-09

Locations

BR (1)